Circulating heavy chain IgG, a pathological mediator for coronary artery disease, recognizes platelet surface receptors of both prostacyclin and insulin

Platelets

Volumn 14, Issue 4, 2003, Pages 203-210

  Kahn, Nighat N ^a,b,d   Bauman, William A ^a,b   Sinha, Asru K ^a,b,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Veterans Administration   (United States)

^c Sinha Inst of Med Sci/Technology   (India)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; INSULIN; ISOPHANE INSULIN; MEMBRANE RECEPTOR; NITRIC OXIDE; PROSTACYCLIN; THROMBOCYTE RECEPTOR;

ADULT; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSS REACTION; DISEASE MARKER; DRUG RECEPTOR BINDING; HUMAN; INCIDENCE; MALE; MORTALITY; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY; SPINAL CORD INJURY; THROMBOCYTE; THROMBOSIS;

ADULT; AMINO ACID SEQUENCE; BLOOD PLATELETS; CASE-CONTROL STUDIES; CORONARY ARTERIOSCLEROSIS; CROSS REACTIONS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; INSULIN; MALE; MIDDLE AGED; NITRIC OXIDE; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTOR, INSULIN; RECEPTORS, EPOPROSTENOL; SEQUENCE HOMOLOGY; SPINAL CORD INJURIES;

EID: 0038049300     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/0953710031000118821     Document Type: Article

References (24)

1. Colman R W, Walsh P N. In: Colman R W, Hirsh J, Marder V J, Saltzman E W, eds. Haemostasis and Thrombosis. Philadelphia, PA: J.B. Lippincott, 1987: 594-605.
2. Furman M I, Beniot S E, Barnard M R, Valeri C R, Borbone M L, Becker R C, Hechtman H B, Michelson A D. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol 1998; 31: 352-8.
3. Hambegr M, Svenson J, Samuelsson B. Thromboxanes: a new group of bioactive compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 1975; 74: 2994-8.
4. Moncada S, Gryglewski R J, Bunting S, Vane J R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable angina substance that inhibits platelet aggregation. Nature 1971; 263: 663-5.
5. Trovati M, Anfossi G, Massucco P, Maltielo L, Costamagna C, Piretto V, Mularoni E, Cavalot F, Bosin A, Ghigo D. Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide increases platelet concentrations of both guanosine 35′ cyclic monophosphate adenosine 3,5′ cyclic monophosphate. Diabetes 1997; 46: 742-9.
6. Sinha A K, Bhattacharya S, Acharya K, Mazumder S. Stimulation of nitric oxide synthesis and protective role of insulin in acute thrombosis in vivo. Life Sci 1999; 65: 2687-96.
7. Ignarro L J. Biosynthesis and metabolism of endothelium derived nitric oxide. Annu Rev Pharmacol Toxicol 1990; 30: 535-60.
8. Sinha A K, Bhattacharya S, Acharya K, Mazumder S, Bauman W A, Kahn N N. Prevention of thrombosis in vivo nitric oxide. Ind J Physiol Allied Sci 1998; 52: 148-61.
9. 1 induced activation of adenylate cyclase in human blood platelet membrane. Biochim Biophys Acta 1988; 972: 45-53.
10. Kahn N N, Bauman W A, Sinha A K. Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. Proc Natl Acad Sci USA 1996; 93: 245-9.
11. 2+ channel blockers. Am J Physiol 1999; 276: E856-62.
12. Kahn N N, Bhattacharya S, Acharya K, Mazumder S, Bauman W A, Sinha A K. Nitric oxide: the 'second messenger' of insulin. IUBMB Life 2000; 49: 441-50.
13. Bauman W A, Kahn N N, Grimm D R, Spungen A M. Risk factors for atherogenesis and cardiovascular autonomic function in persons with spinal cord injury. Spinal Cord 1999; 37: 601-16.
14. Samsa G P, Patric C H, Feussner J R. Long term survival of veterans with traumatic spinal cord injury. Arch Neurol 1993; 50: 909-14.
15. Kahn N N, Bauman W A, Sinha A K. Demonstration of a novel circulating anti-prostacyclin receptor antibody. Proc Natl Acad Sci USA 1997; 94: 8779-82.
16. Yalow R S, Berson S A. Immunoassay of endogenous insulin in man. J Clin Invest 1960; 39: 1157-75.
17. 1 binding to human platelet membrane by insulin and the activation of adenylate cyclase. J Biol Chem 1990; 265: 4976-81.
18. Kahn N N, Bauman W A, Sinha A K. Transient decrease of binding of insulin to platelets in acute ischemic heart disease. Am J Med Sci 1994; 307: 21-6.
19. Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660-70.
20. Laemmli U K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 1970; 227: 680-5.
21. Towbin M, Staehlin Y, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedures and some applications. Proc Natl Acad Sci USA 1989; 76: 43-5.
22. Roth R A. Insulin. In: Cuatrecasas P, Jacobs S, eds. Handbook of Experimental Pharmacology, Vol. 92. Berlin: Springer, 1990: 169-81.
23. Huang X, Miller W. A time efficient linear space local similarity algorithm. Adv Appl Math 1991; 12: 337-57.
24. Search Launcher. BCM.TMC.edu