Platelet-stimulated thrombin and PDGF are normalized by insulin and Ca2+ channel blockers

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 5 39-5, 1999, Pages

  Kahn, Nighat N ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Coronary artery disease; Platelet derived growth factor adenosine 3',5', cyclic monophosphate; Prostacyclin; Prostaglandin E1; Receptor

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLIC AMP; INSULIN; ISOPHANE INSULIN; MITOGENIC AGENT; NIFEDIPINE; PIMOZIDE; PLATELET DERIVED GROWTH FACTOR; PROSTACYCLIN; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN RECEPTOR; THROMBIN; VERAPAMIL;

ADULT; ARTICLE; ATHEROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; INSULIN TREATMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; SPINAL CORD INJURY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

EID: 0033040730     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.5.e856     Document Type: Article

References (42)

1. Badimon, L., J. H. Chesebro, and J. J. Badimon. Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi. Circulation 86, Suppl. 6:III74-85, 1992.
2. Bauman, W. A., M. A. Raza, A. M. Spungen, and J. Machac. Cardiac stress testing with thallium-201 imaging reveals silent ischemia in individuals with paraplegia. Arch. Phys. Med. Rehabil. 75: 946-950, 1994.
3. Brune, B., and V. Ullrich. Cyclic nucleotides, and intracellular homeostasis in human platelets. Eur. J. Biochem. 207: 607-613, 1992.
4. Cimminiello, C., G. Arpaia, M. Aloisio, T. Umberti, F. Rossi, F. Pozzi, and G. Bonfardeci. Platelet-derived growth factor (PDGF) in patients with different degrees of chronic arterial obstructive disease. Angiology 45: 289-293, 1994.
5. Colman, R. W., V. J. Marder, E. W. Salzman, and J. Hirch. Overview of hemostasis and thrombosis. In: Hemostasis and Thrombosis, edited by R. W. Colman, J. Hirch, V. J. Marder, and E. W. Salzman. Philadelphia, PA: Lippincott, 1987, p. 3-17.
6. Coughlin, S. R., T.-K. H. Vu., D. T. Hing, and V. I. Wheaton. Characterization of a functional thrombin receptor. J. Clin. Invest. 89: 351-355, 1992.
7. DiCorleto, P. E. Cellular mechanism of atherogenesis. Am. J. Hypertens. 11: 314S-318S, 1993.
8. 2 receptor of human blood platelets. J. Biol. Chem. 262: 12687-12691, 1987.
9. Gieger, J., C. Nolte, and U. Walter. Regulation of calcium mobilization and entry in human platelets by endothelialderived factors. Am. J. Physiol. 267 (Cell Physiol. 36): C236-C244, 1994.
10. Gilman, A. G. A protein binding assay for 3′ :5′-cyclic monophosphate. Proc. Natl. Acad. Sci. USA 67: 305-312, 1970.
11. Haslam, R. J. Roles of cyclic nucleotide in platelet function. Ciba Found. Symp. 35: 121-151, 1975.
12. Holmsen, H. Platelet secretion. In: Hemostasis and Thrombosis. edited by R. W. Colman, J. Hirch, V. J. Marder, and E. W. Salzman. Philadelphia, PA: Lippincott, 1987, p. 804-815.
13. Hougie, C. Recalcification time test and its modifications. Partial thromboplastin time, activated partial thromboplastin time. In Hemotology, edited by W. J. William, E. B. Butler, A. J. Erstlev, and R. W. Rundles. New York: McGraw-Hill, 1977, p. 1642-1645.
14. 2+ extrusion from human platelets. Biochim. Biophys. Acta 1105: 19-28, 1992.
15. iα protein. Life Sci. 63: 2031-2038, 1998.
16. Kahn, N. N., W. A. Bauman, V. A. Hatcher, and A. K. Sinha. Inhibition of platelet aggregation and the stimulation of prostacyclin sysnthesis by insulin in humans. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H2160-H2167, 1993.
17. Kahn, N. N., W. A. Bauman, and A. K. Sinha. Insulin-induced release of plasminogen activator from human blood platelets. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H117-H124, 1995.
18. Kahn, N. N., W. A. Bauman, and A. K. Sinha. Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. Proc. Natl. Acad. Sci. USA 93: 245-249, 1996.
19. Kahn, N. N., W. A. Bauman, and A. K. Sinha. Demonstration of a novel circulating anti-prostacyclin receptor antibody. Proc. Natl. Acad. Sci. USA 94: 8779-8782, 1997.
20. 2 receptor activity of human blood platelets in acute ischemic heart disease. Circ. Res. 66: 932-940, 1990.
21. 2 receptor activity of platelets in acute ischemic heart disease. Circ. Res. 68: 245-254, 1991.
22. 2 and synthesis of prostacyclin by insulin in unstable angina pectoris and in acute myocardial infarction. Am. J. Cardiol. 70: 582-586, 1992.
23. 1 binding to human platelet membrane by insulin and the activation of adenylate cyclase. J. Biol. Chem. 265: 4976-4981, 1990.
24. 1-induced activation of adenylate cyclase in human blood platelet membrane. Biochim. Biophys. Acta 972: 45-53, 1988.
25. Kim, H. R. C., S. Upadhyay, G. Li, K. C. Palmer, and T. F. Deuel. Platelet-derived factor induces apoptosis in growth-arrested murine fibroblasts. Proc. Natl. Acad. Sci. USA 92: 9500-9504, 1995.
26. Lacoste, L., L. Y. Lam, J. Hung, D. Walters. Oral verapamil inhibits platelet thrombus formation in humans. Circulation 89: 603-604, 1994.
27. Lefkowitz, R. J., D. Mullikin, C. L. Wood, T. B. Gore, and C. Mukherjee. Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythocytes. J. Biol. Chem. 252: 5295-5303, 1977.
28. Marcus, A. J., and L. B. Safier. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 7: 516-522, 1993.
29. Moncada, S., R. J. Gryglewski, S. Bunting, and J. R. Vane. An enzyme isolated from arteries transforms prostaglandin peroxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663-665, 1976.
30. Ouchi, Y., and H. Orimo. The role of calcium antagonists in the treatment of atherosclerosis and hypertension. J. Cardiovasc. Pharmacol. 16: 1-4, 1990.
31. Rink, T. J., and S. O. Sage. Calcium signalling in human platelets. Annu. Rev. Physiol. 52: 431-449, 1990.
32. Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature 363: 801-809, 1993.
33. Ross, R., P. D. F. Bowen-Pope, and E. W. Raines. Platelet-derived growth factor and its role in health and disease. Philos. Trans. R. Soc. Lond. B Biol. Sci. 327: 155-169, 1990.
34. Saito, F., M. T. Hori, M. Fittingoff, T. Hino, and M. L. Tuck. Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells. J. Clin. Invest. 92: 1161-1167, 1993.
35. Scatchard, G. The attraction of proteins for small molecules and ions. Ann. NY Acad. Sci. 51: 660-670, 1949.
36. 2. J. Biol. Chem. 254: 2914-2917, 1979.
37. Shultz, P. J., T. C. Knauss, P. Mene, and H. E. Abboud. Mitogenic signals for thrombin in mesengial cells: regulation of phospholipase C and PDGF genes. Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26): F366-F374, 1989.
38. 2 synthesis in human platelets by coagulation factor Xa. Proc. Natl. Acad. Sci. USA 80: 6086-6090, 1983.
39. Stemerman, M. B. Relationship of Thrombosis to Atherosclerosis. Philadelphia, PA: Lippincott, 1987, p. 1136-1142.
40. Weksler, B. B. Platelet interactions with blood vessel wall. In: Hemostasis and Thrombosis, edited by R. W. Colman, J. Hirch, V. J. Marder, and E. W. Salzman. Philadephia, PA: Lippincott, 1987, p 804-815.
41. Willerson, J. T. Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products. Tex. Heart Inst. J. 22: 13-19, 1995.
42. 2. Circulation 89: 2266-2272, 1994.