메뉴 건너뛰기




Volumn 133, Issue 1, 2003, Pages 132-138

Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis

Author keywords

Leflunomide; MCP 1; MDC; Rheumatoid arthritis; TARC

Indexed keywords

ANTIRHEUMATIC AGENT; C REACTIVE PROTEIN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; COMPLEMENTARY DNA; CORTICOSTEROID; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 15; LEFLUNOMIDE; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; METHOTREXATE; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; RHEUMATOID FACTOR; RNA; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

EID: 0038047045     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02192.x     Document Type: Article
Times cited : (27)

References (40)
  • 1
    • 0025868134 scopus 로고
    • The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease
    • Sharp JT, Wolfe F, Mitchell DM, Bloch DA. The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease. Arthritis Rheum 1991; 34:660-8.
    • (1991) Arthritis Rheum , vol.34 , pp. 660-668
    • Sharp, J.T.1    Wolfe, F.2    Mitchell, D.M.3    Bloch, D.A.4
  • 2
    • 0030970556 scopus 로고    scopus 로고
    • The role of T cells in the immunopathogenesis of rheumatoid arthritis: New perspectives
    • Fox DA. The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum 1997; 40:598-609.
    • (1997) Arthritis Rheum , vol.40 , pp. 598-609
    • Fox, D.A.1
  • 3
    • 0342578133 scopus 로고    scopus 로고
    • Mononuclear phagocytes and rheumatoid synovitis: Mastermind or workhorse in arthritis?
    • Burmester GR, Stuhlmuller B, Keyszer G, Kinne RW. Mononuclear phagocytes and rheumatoid synovitis: mastermind or workhorse in arthritis? Arthritis Rheum 1997; 40:5-18.
    • (1997) Arthritis Rheum , vol.40 , pp. 5-18
    • Burmester, G.R.1    Stuhlmuller, B.2    Keyszer, G.3    Kinne, R.W.4
  • 5
    • 0030117013 scopus 로고    scopus 로고
    • Cellular adhesion molecules in rheumatoid arthritis: Regulation by cytokines and possible clinical importance
    • Szekanecz Z, Szegedi G, Koch AE. Cellular adhesion molecules in rheumatoid arthritis: regulation by cytokines and possible clinical importance. J Invest Med 1996; 44:124-35.
    • (1996) J Invest Med , vol.44 , pp. 124-135
    • Szekanecz, Z.1    Szegedi, G.2    Koch, A.E.3
  • 7
    • 0033053835 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
    • European Leflunomide Study Group
    • Smolen JS, Kalden JR, Scott DL et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet 1999; 353:259-66.
    • (1999) Lancet , vol.353 , pp. 259-266
    • Smolen, J.S.1    Kalden, J.R.2    Scott, D.L.3
  • 8
    • 0029591467 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
    • Cherwinski HM, Cohn RG, Cheung P et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995; 275:1043-9.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1043-1049
    • Cherwinski, H.M.1    Cohn, R.G.2    Cheung, P.3
  • 9
    • 0031865023 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide in rheumatoid arthritis
    • Fox RI. Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol 1998; 25 (Suppl. 53):20-6.
    • (1998) J Rheumatol , vol.25 , Issue.SUPPL. 53 , pp. 20-26
    • Fox, R.I.1
  • 10
    • 0029959051 scopus 로고    scopus 로고
    • Rationale for combination therapy of rheumatoid arthritis based on pathophysiology
    • Harris ED. Rationale for combination therapy of rheumatoid arthritis based on pathophysiology. J Rheumatol 1996; 23 (Suppl. 44):2-4.
    • (1996) J Rheumatol , vol.23 , Issue.SUPPL. 44 , pp. 2-4
    • Harris, E.D.1
  • 11
    • 0009871302 scopus 로고    scopus 로고
    • Methotrexate
    • Firestein, GS, Panayi, GS, Wollheim, FA, eds. New York: Oxford University Press, Inc.
    • Rau R. Methotrexate. In: Firestein, GS, Panayi, GS, Wollheim, FA, eds. Rheumatoid arthritis: new frontiers in pathogenesis and treatment. New York: Oxford University Press, Inc., 2000:337-50.
    • (2000) Rheumatoid Arthritis: New Frontiers in Pathogenesis and Treatment , pp. 337-350
    • Rau, R.1
  • 12
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells
    • Genestier L, Paillot R, Fournel S, Ferraro C, Miossec P, Revillard J. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest 1998; 102:322-8.
    • (1998) J Clin Invest , vol.102 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3    Ferraro, C.4    Miossec, P.5    Revillard, J.6
  • 13
    • 0343396569 scopus 로고    scopus 로고
    • Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis
    • Katschke KJ, Rottman JB, Ruth JH et al. Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum 2001; 44:1022-32.
    • (2001) Arthritis Rheum , vol.44 , pp. 1022-1032
    • Katschke, K.J.1    Rottman, J.B.2    Ruth, J.H.3
  • 14
    • 0034799718 scopus 로고    scopus 로고
    • Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis
    • Katrib A, Tak PP, Bertouch JV et al. Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis. Rheumatology (Oxford) 2001; 40:988-94.
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 988-994
    • Katrib, A.1    Tak, P.P.2    Bertouch, J.V.3
  • 16
    • 0027422814 scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium
    • Harigai M, Hara M, Yoshimura T, Leonard EJ, Inoue K, Kashiwazaki S. Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium. Clin Immunol Immunopathol 1993; 69:83-91.
    • (1993) Clin Immunol Immunopathol , vol.69 , pp. 83-91
    • Harigai, M.1    Hara, M.2    Yoshimura, T.3    Leonard, E.J.4    Inoue, K.5    Kashiwazaki, S.6
  • 17
    • 0027407715 scopus 로고
    • Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor alpha and interferon-gamma
    • Hachicha M, Rathanaswami P, Schall TJ, McColl SR. Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor alpha and interferon-gamma. Arthritis Rheum 1993; 36:26-34.
    • (1993) Arthritis Rheum , vol.36 , pp. 26-34
    • Hachicha, M.1    Rathanaswami, P.2    Schall, T.J.3    McColl, S.R.4
  • 18
    • 0033430364 scopus 로고    scopus 로고
    • Chemokine production by human chondrocytes
    • Pulsatelli L, Dolzani P, Piacentini A et al. Chemokine production by human chondrocytes. J Rheumatol 1999; 26:1992-2001.
    • (1999) J Rheumatol , vol.26 , pp. 1992-2001
    • Pulsatelli, L.1    Dolzani, P.2    Piacentini, A.3
  • 19
    • 0035162479 scopus 로고    scopus 로고
    • Plasma monocyte chemoattractant protein 1 is a marker for joint inflammation in rheumatoid arthritis
    • Ellingsen T, Buus A, Stengaard-Pedersen K. Plasma monocyte chemoattractant protein 1 is a marker for joint inflammation in rheumatoid arthritis. J Rheumatol 2001; 28:41-6.
    • (2001) J Rheumatol , vol.28 , pp. 41-46
    • Ellingsen, T.1    Buus, A.2    Stengaard-Pedersen, K.3
  • 20
    • 0035080352 scopus 로고    scopus 로고
    • Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
    • Hayashida K, Nanki T, Girschick H, Yavuz S, Ochi T, Lipsky PE. Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8. Arthritis Res 2001; 3:118-26.
    • (2001) Arthritis Res , vol.3 , pp. 118-126
    • Hayashida, K.1    Nanki, T.2    Girschick, H.3    Yavuz, S.4    Ochi, T.5    Lipsky, P.E.6
  • 21
    • 0030714683 scopus 로고    scopus 로고
    • Novel lymphocyte-specific CC chemokines and their receptors
    • Yoshie O, Imai T, Nomiyama H. Novel lymphocyte-specific CC chemokines and their receptors. J Leukoc Biol 1997; 62:634-44.
    • (1997) J Leukoc Biol , vol.62 , pp. 634-644
    • Yoshie, O.1    Imai, T.2    Nomiyama, H.3
  • 22
    • 0030912069 scopus 로고    scopus 로고
    • Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells
    • Godiska R, Chantry D, Raport C et al. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 1997; 185:1595-604.
    • (1997) J Exp Med , vol.185 , pp. 1595-1604
    • Godiska, R.1    Chantry, D.2    Raport, C.3
  • 23
    • 0033021857 scopus 로고    scopus 로고
    • Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner
    • Bochner BS, Bickel CA, Taylor ML et al. Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner. J Allergy Clin Immunol 1999; 103:527-32.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 527-532
    • Bochner, B.S.1    Bickel, C.A.2    Taylor, M.L.3
  • 24
    • 0035864775 scopus 로고    scopus 로고
    • The CC chemokines MDC and TARC induce platelet activation via CCR4
    • Abi-Younes S, Si-Tahar M, Luster AD. The CC chemokines MDC and TARC induce platelet activation via CCR4. Thromb Res 2001; 101:279-89.
    • (2001) Thromb Res , vol.101 , pp. 279-289
    • Abi-Younes, S.1    Si-Tahar, M.2    Luster, A.D.3
  • 25
    • 0034670031 scopus 로고    scopus 로고
    • Leflunomide suppresses TNF-induced cellular responses, effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
    • Manna SK, Mukhopadhyay A, Aggarwal BB. Leflunomide suppresses TNF-induced cellular responses, effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol 2000; 165:5962-9.
    • (2000) J Immunol , vol.165 , pp. 5962-5969
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 26
    • 0033947789 scopus 로고    scopus 로고
    • Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: Findings in a prospective, randomized, double-blind clinical trial in fifteen patients
    • Kraan MC, de Koster BM, Elferink JG, Post WJ, Breedveld FC, Tak PP. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum 2000; 43:1488-95.
    • (2000) Arthritis Rheum , vol.43 , pp. 1488-1495
    • Kraan, M.C.1    De Koster, B.M.2    Elferink, J.G.3    Post, W.J.4    Breedveld, F.C.5    Tak, P.P.6
  • 27
    • 0033764113 scopus 로고    scopus 로고
    • Leflunomide: Mode of action in the treatment of rheumatoid arthritis
    • Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 2000; 59:841-9.
    • (2000) Ann Rheum Dis , vol.59 , pp. 841-849
    • Breedveld, F.C.1    Dayer, J.M.2
  • 28
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3
  • 29
    • 0028813226 scopus 로고
    • Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity
    • Smolen JS, Breedveld FC, Eberl G et al. Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity. Arthritis Rheum 1995; 38:38-43.
    • (1995) Arthritis Rheum , vol.38 , pp. 38-43
    • Smolen, J.S.1    Breedveld, F.C.2    Eberl, G.3
  • 30
    • 3543073369 scopus 로고    scopus 로고
    • Cross cultural adaptation and validation of the Chinese Health Assessment Questionnaire for use in rheumatoid arthritis
    • Koh ET, Seow A, Pong LY et al. Cross cultural adaptation and validation of the Chinese Health Assessment Questionnaire for use in rheumatoid arthritis. J Rheumatol 1998; 25:1705-8.
    • (1998) J Rheumatol , vol.25 , pp. 1705-1708
    • Koh, E.T.1    Seow, A.2    Pong, L.Y.3
  • 31
    • 0027238592 scopus 로고
    • The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials
    • Felson DT, Anderson JJ, Boers M et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum 1993; 36:729-40.
    • (1993) Arthritis Rheum , vol.36 , pp. 729-740
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3
  • 32
    • 0033509841 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis
    • Weinblatt ME, Kremer JM, Coblyn JS et al. Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999; 42:1322-8.
    • (1999) Arthritis Rheum , vol.42 , pp. 1322-1328
    • Weinblatt, M.E.1    Kremer, J.M.2    Coblyn, J.S.3
  • 33
    • 0032804664 scopus 로고    scopus 로고
    • Mechanism of action for leflunomide in rheumatoid arthritis
    • Fox RI, Herrmann ML, Frangou CG et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol 1999; 93:198-208.
    • (1999) Clin Immunol , vol.93 , pp. 198-208
    • Fox, R.I.1    Herrmann, M.L.2    Frangou, C.G.3
  • 34
    • 0032838994 scopus 로고    scopus 로고
    • T cells: Pathogenic cells and therapeutic targets in rheumatoid arthritis
    • Yocum DE. T cells: pathogenic cells and therapeutic targets in rheumatoid arthritis. Semin Arthritis Rheum 1999; 29:27-35.
    • (1999) Semin Arthritis Rheum , vol.29 , pp. 27-35
    • Yocum, D.E.1
  • 35
    • 0033037205 scopus 로고    scopus 로고
    • Dendritic cells and MPIF-1: Chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation
    • Nardelli B, Morahan DK, Bong GW, Semenuk MA, Kreider BL, Garotta G. Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation. J Leukoc Biol 1999; 65:822-8.
    • (1999) J Leukoc Biol , vol.65 , pp. 822-828
    • Nardelli, B.1    Morahan, D.K.2    Bong, G.W.3    Semenuk, M.A.4    Kreider, B.L.5    Garotta, G.6
  • 36
    • 0032928572 scopus 로고    scopus 로고
    • Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1
    • Nardelli B, Tiffany HL, Bong GW et al. Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. J Immunol 1999; 162:435-44.
    • (1999) J Immunol , vol.162 , pp. 435-444
    • Nardelli, B.1    Tiffany, H.L.2    Bong, G.W.3
  • 37
    • 0033871183 scopus 로고    scopus 로고
    • CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipo-protein (a) in human vascular endothelial cells
    • Haque NS, Zhang X, French DL et al. CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipo-protein (a) in human vascular endothelial cells. Circulation 2000; 102:786-92.
    • (2000) Circulation , vol.102 , pp. 786-792
    • Haque, N.S.1    Zhang, X.2    French, D.L.3
  • 38
    • 0030770739 scopus 로고    scopus 로고
    • TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development
    • Vicari AP, Figueroa DJ, Hedrick JA et al. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 1997; 7:291-301.
    • (1997) Immunity , vol.7 , pp. 291-301
    • Vicari, A.P.1    Figueroa, D.J.2    Hedrick, J.A.3
  • 39
    • 0029800741 scopus 로고    scopus 로고
    • The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines
    • Al-Mughales J, Blyth TH, Hunter JA, Wilkinson PC. The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines. Clin Exp Immunol 1996; 106:230-6.
    • (1996) Clin Exp Immunol , vol.106 , pp. 230-236
    • Al-Mughales, J.1    Blyth, T.H.2    Hunter, J.A.3    Wilkinson, P.C.4
  • 40
    • 0030022275 scopus 로고    scopus 로고
    • The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
    • McInnes IB, al-Mughales J, Field M et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996; 2:175-82.
    • (1996) Nat Med , vol.2 , pp. 175-182
    • McInnes, I.B.1    Al-Mughales, J.2    Field, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.