A prolonged immune response to antigen delivered in poly (∈-caprolactone) microparticles

Immunology and Cell Biology

Volumn 81, Issue 3, 2003, Pages 185-191

  Slobbe, Lynn ^a   Medlicott, Natalie ^a   Lockhart, Euan ^a   Davies, Nigel ^a   Tucker, Ian ^a   Razzak, Majid ^a   Buchan, Glenn ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Antibody; Cell mediated immunity; IFN ; Immunity; Microparticulate delivery; Poly caprolactone; Vaccine

Indexed keywords

ANTIGEN; OVALBUMIN; POLYCAPROLACTONE; VACCINE; WATER OIL CREAM;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DELAYED DRUG RELEASE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG POTENCY; ENCAPSULATION; EVAPORATION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; INFECTION; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; SHELF LIFE; SINGLE DRUG DOSE; SOLUBILITY; SURFACE PROPERTY; VACCINATION;

ANIMALS; ANTIBODY FORMATION; BIODEGRADATION, ENVIRONMENTAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEXANOIC ACIDS; LACTONES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; OVALBUMIN; PARTICLE SIZE; POLYMERS; VACCINES;

ANIMALIA;

EID: 0038018179     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2003.01155.x     Document Type: Article

References (17)

1. Gray D. A role for antigen in the maintenance of immunological memory. Nat. Rev. Immunol. 2002; 2: 60-5.
2. + T cell effectors can become memory cells with high efficiency and without further division. Nat. Immunol. 2001; 2: 705-10.
3. Matzinger P. The danger model: a renewed sense of self. Science 2002; 296: 301-5.
4. Salisbury D. Introduction of a conjugate meningococcal type C vaccine programme in the UK. J. Pediatr. Child Health 2001; 37: S34-6.
5. Szmuness W, Stevens C, Harley E et al. Hepatitis B vaccine: Demonstration of efficacy in a controlled trial in a high risk population in the US. N. Engl. J. Med. 1980; 303: 833-41.
6. Spiers I, Eyles J, Baillie L, Williamson E, Alpar O. Biodegradable microparticles with different release profiles: effect on the immune response after a single administration via intranasal and intramuscular routes. J. Pharm. Pharmacol. 2000; 52: 1195-201.
7. Jenkins P, Coombes A, Yeh M, Thomas N, Davis S. Aspects of the design and delivery of microparticles for vaccine application. J. Drug Target 1995; 3: 79-81.
8. Harding C, Collins D, Slot J, Geuze H, Unanue E. Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell 1991; 64: 393-401.
9. Eldridge J, Staas J, Meulbroek J, McGhee J, Tice T, Gilley R. Biodegradable microspheres as a vaccine delivery system. Mol. Immunol. 1991; 28: 287-94.
10. Murillo M, Grillo M, Rene J et al. A Brucella ovis antigenic complex bearing poly-∈-caprolactone microparticles confer protection against experimental brucellosis in mice. Vaccine 2001; 19: 4099-106.
11. Sharma A, Verma I, Tewari R, Khuller G. Adjuvant modulation of T-cell reactivity to 30-kDa secretory protein of Mycobacterium tuberculosis H37Rv and its protective efficacy against experimental tuberculosis. J. Med. Microbiol. 1999; 48: 757-63.
12. Conway M, Madrigal-Estebas L, McClean S, Brayden D, Mills K. Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine 2001; 19: 1940-50.
13. Uchida T, Goto S, Foster T. Particle size studies for subcutaneous delivery of poly (lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation. J. Pharm. Pharmacol. 1994; 47: 556-60.
14. O'Hagan D, Jeffery H, Davis S. Long-term antibody responses in mice following subcutaneous immunisation with ovalbumin entrapped in biodegradable microparticles. Vaccine 1993; 11: 965-9.
15. Eldridge J, Staas J, Meulbroek J, Tice T, Gilley R. Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralising antibodies. Infect. Immun. 1991; 59: 2978-86.
16. Coombes A, Lavelle E, Jenkins P, Davis S. Single dose, polymeric, microparticle-based vaccines. The influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen. Vaccine 1996; 14: 1429-38.
17. Newman K, Samuel J, Kwon G. Ovalbumin peptide encapsulated in poly (d.1 lactic-co-glycolic acid) microspheres is capable of inducing a T helper type 1 immune response. J. Control Release 1998; 54: 49-59.