메뉴 건너뛰기




Volumn 4, Issue 5, 2003, Pages 611-623

Current best treatment for non-alcoholic fatty liver disease

Author keywords

tocopherol; Antioxidants; Atorvastatin; Betaine; Derivatives; Diabetes mellitus; Gemfibrozil; Hepatoprotective; Hyperlipidaemia; Insulin resistance; Insulin sensitising; Iron depletion; Metformin; N acetylcysteine; Non alcoholic fatty liver; Non alcoholic steatohepatitis; Obesity; Oxidative stress; Phlebotomy; Pioglitazone; Rosiglitazone; Steatosis; Thiazolidinedione; Troglitazone; Ursodeoxycholic acid; Vatamin E; Vitamin C

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; AMIODARONE; ANTIOXIDANT; ANTIVIRUS AGENT; ASCORBIC ACID; BETAINE; CALCIUM CHANNEL BLOCKING AGENT; CLOFIBRATE; DIDANOSINE; ESTROGEN DERIVATIVE; FIALURIDINE; GEMFIBROZIL; GLUCOCORTICOID; GLUCOSE; GLUCURONIC ACID; LIPID; METFORMIN; METHOTREXATE; PERHEXILINE MALEATE; PIOGLITAZONE; ROSIGLITAZONE; TAMOXIFEN; TETRACYCLINE; TROGLITAZONE; UNINDEXED DRUG; URSODEOXYCHOLIC ACID; VALPROIC ACID; ZIDOVUDINE;

EID: 0038017098     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.4.5.611     Document Type: Review
Times cited : (44)

References (81)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • ANGULO P: Nonalcoholic fatty liver disease. N. Engl. J. Med. (2002) 346:1221-1231.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 0035088211 scopus 로고    scopus 로고
    • Insulin resistance and mitochondrial abnormalities in NASH: A cool look into a burning issue
    • ANGULO P, LINDOR KD: Insulin resistance and mitochondrial abnormalities in NASH: a cool look into a burning issue. Gastroenterology (2001) 120:1281-1285.
    • (2001) Gastroenterology , vol.120 , pp. 1281-1285
    • Angulo, P.1    Lindor, K.D.2
  • 4
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
    • RATZIU V, BONYHAY L, DI MARTINO V et al.: Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis. Hepatology (2002) 35:1485-1493.
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.1    Bonyhay, L.2    Di Martino, V.3
  • 5
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • BUGIANESI E, LEONE N, VANNI E et al.: Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology (2002) 123:134-140.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 6
    • 0024336332 scopus 로고
    • Nonalcoholic steatohepatitis. A study of 49 patients
    • LEE RG: Nonalcoholic steatohepatitis. A study of 49 patients. Hum. Pathol. (1989) 20:594-599.
    • (1989) Hum. Pathol. , vol.20 , pp. 594-599
    • Lee, R.G.1
  • 7
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow up study of forty-two patients for up to 21 years
    • POWELL EE, COOKSLEY WG, HANSON R, SEARLE J, HALLIDAY JW, POWELL LW: The natural history of nonalcoholic steatohepatitis: a follow up study of forty-two patients for up to 21 years. Hepatology (1990) 11:74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 9
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow up study
    • TELI M, OLIVER FW, BURT AD, BENNET MK, DAY CP: The natural history of nonalcoholic fatty liver: a follow up study. Hepatology (1995) 22:1714-1717.
    • (1995) Hepatology , vol.22 , pp. 1714-1717
    • Teli, M.1    Oliver, F.W.2    Burt, A.D.3    Bennet, M.K.4    Day, C.P.5
  • 10
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • MATTEONI CA, YOUNOSSI ZM, GRAMLICH TL et al.: Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology (1999) 116:1413-1419.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.L.3
  • 11
    • 0034116558 scopus 로고    scopus 로고
    • Liver fibrosis in overweight patients
    • RATZIU V, GIRAL P, CHARLOTTE F et al.: Liver fibrosis in overweight patients. Gastroenterology (2000) 118:1117-1123.
    • (2000) Gastroenterology , vol.118 , pp. 1117-1123
    • Ratziu, V.1    Giral, P.2    Charlotte, F.3
  • 12
    • 0035085858 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver: Present and emerging therapies
    • ANGULO P, LINDOR KD: Treatment of nonalcoholic fatty liver: present and emerging therapies. Sem Liver Dis (2001) 21:81-88.
    • (2001) Sem. Liver Dis. , vol.21 , pp. 81-88
    • Angulo, P.1    Lindor, K.D.2
  • 14
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • ANGULO P, KEACH JC, BATTS KP, LINDOR KD: Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology (1999) 30:1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 15
    • 0023801758 scopus 로고
    • Alcohol-like liver disease in nonalcoholic. A clinical and histological comparison with alcohol-induced liver injury
    • DIEHL AM, GOODMAN Z, ISHAK KG: Alcohol-like liver disease in nonalcoholic. A clinical and histological comparison with alcohol-induced liver injury. Gastroenterology (1989) 95:1056-1060.
    • (1989) Gastroenterology , vol.95 , pp. 1056-1060
    • Diehl, A.M.1    Goodman, Z.2    Ishak, K.G.3
  • 16
    • 0022492463 scopus 로고
    • Nonalcoholic steatohepatitis in obesity: A reversible condition
    • ERIKSSON S, ERIKSSON KF, BONDESSON L: Nonalcoholic steatohepatitis in obesity: a reversible condition. Acta Med. Scand (1986) 220:83-88.
    • (1986) Acta Med. Scand , vol.220 , pp. 83-88
    • Eriksson, S.1    Eriksson, K.F.2    Bondesson, L.3
  • 17
    • 0014051568 scopus 로고
    • Liver morphology and function tests in obesity and during total starvation
    • ROZENTAL P, BIAVA C, SPENCER H et al.: Liver morphology and function tests in obesity and during total starvation. Am. J. Dig. Dis. (1967) 12:198-208.
    • (1967) Am. J. Dig. Dis. , vol.12 , pp. 198-208
    • Rozental, P.1    Biava, C.2    Spencer, H.3
  • 18
    • 0014937883 scopus 로고
    • Effect on hepatic morphology of treatment of obesity by fasting, reducing diets, and small bowel bypass
    • DRENICK EJ, SIMMONS F, MURPHY J: Effect on hepatic morphology of treatment of obesity by fasting, reducing diets, and small bowel bypass. N. Engl. J. Med. (1970) 282:829-834.
    • (1970) N. Engl. J. Med. , vol.282 , pp. 829-834
    • Drenick, E.J.1    Simmons, F.2    Murphy, J.3
  • 19
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • PALMER M, SCHAFFNER F: Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology (1990) 99:1408-1413.
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 20
  • 21
    • 0030740659 scopus 로고    scopus 로고
    • Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
    • UENO T, SUGAWARA H, SUJAKU K et al.: Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J. Hepatol. (1997) 27:103-107.
    • (1997) J. Hepatol. , vol.27 , pp. 103-107
    • Ueno, T.1    Sugawara, H.2    Sujaku, K.3
  • 22
    • 0028022928 scopus 로고
    • Persistent hyperaminotransferasemia resolving after weight reduction in obese children
    • VAJRO P, FONTANELLA A, PERNA C, ORSO G, TEDESCO M, DE VICENZO A: Persistent hyperaminotransferasemia resolving after weight reduction in obese children. J. Pediatr. (1994) 125:239-241.
    • (1994) J. Pediatr. , vol.125 , pp. 239-241
    • Vajro, P.1    Fontanella, A.2    Perna, C.3    Orso, G.4    Tedesco, M.5    De Vicenzo, A.6
  • 23
    • 0030872385 scopus 로고    scopus 로고
    • Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population
    • FRANZESE A, VAJRO P, ARGENZIANO A et al.: Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population. Dig. Dis. Sci. (1997) 42:1428-1432.
    • (1997) Dig. Dis. Sci. , vol.42 , pp. 1428-1432
    • Franzese, A.1    Vajro, P.2    Argenziano, A.3
  • 25
    • 0032575852 scopus 로고    scopus 로고
    • Anonymous: Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults
    • Anonymous: Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Arch. Intern. Med. (1998) 158:1855-1867.
    • (1998) Arch. Intern. Med. , vol.158 , pp. 1855-1867
  • 26
    • 0033755730 scopus 로고    scopus 로고
    • AHA dietary guidelines: Revision 2000. A statement for health care professionals from the nutrition committee of the American Heart Association
    • KRAUS RM, ECKEL RH, HOWARD B et al.: AHA dietary guidelines: revision 2000. A statement for health care professionals from the nutrition committee of the American Heart Association. Stroke (2000) 31:2751-2766.
    • (2000) Stroke , vol.31 , pp. 2751-2766
    • Kraus, R.M.1    Eckel, R.H.2    Howard, B.3
  • 27
    • 0033862760 scopus 로고    scopus 로고
    • Diabetes guidelines: A summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists
    • Discussion 898
    • CLARK MJ JR, STERRETT JJ, CARSON DS: Diabetes guidelines: a summary and comparison of the recommendations of the American Diabetes Association, Veterans Health Administration, and American Association of Clinical Endocrinologists. Clin. Ther. (2000) 22:899-910; Discussion 898.
    • (2000) Clin. Ther. , vol.22 , pp. 899-910
    • Clark M.J., JR.1    Sterrett, J.J.2    Carson, D.S.3
  • 28
    • 0030915582 scopus 로고    scopus 로고
    • Steatosis and collagen content in experimental liver cirrhosis are affected by dietary monounsaturated and polyunsaturated fatty acids
    • FERNANDEZ MI, TORRES MI, RIOS A. Steatosis and collagen content in experimental liver cirrhosis are affected by dietary monounsaturated and polyunsaturated fatty acids. Scand. J. Gastroenterol. (1997) 32:350-356.
    • (1997) Scand. J. Gastroenterol. , vol.32 , pp. 350-356
    • Fernandez, M.I.1    Torres, M.I.2    Rios, A.3
  • 29
    • 0036234267 scopus 로고    scopus 로고
    • Pharmacological approaches for the treatment of obesity
    • FERNANDEZ-LOPEZ JA, REMESAR X, FOZ M, ALEMANY M: Pharmacological approaches for the treatment of obesity. Drugs (2002) 62:915-944.
    • (2002) Drugs , vol.62 , pp. 915-944
    • Fernandez-lopez, J.A.1    Remesar, X.2    Foz, M.3    Alemany, M.4
  • 30
    • 0017029372 scopus 로고
    • Intestinal bypass surgery for morbid obesity. Long term results
    • DEWIND LT, PAYNE JH: Intestinal bypass surgery for morbid obesity. Long term results. JAMA (1976) 236:2298-2301.
    • (1976) JAMA , vol.236 , pp. 2298-2301
    • Dewind, L.T.1    Payne, J.H.2
  • 32
    • 0018763278 scopus 로고
    • Protein supplementation in the management of degenerating liver function after jejunoileal bypass
    • ACKERMAN NB: Protein supplementation in the management of degenerating liver function after jejunoileal bypass. Surg. Gynecol. Obstet. (1979) 149:8-14.
    • (1979) Surg. Gynecol. Obstet. , vol.149 , pp. 8-14
    • Ackerman, N.B.1
  • 33
    • 0020065283 scopus 로고
    • Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazol, irrespective of protein-calorie malnutrition
    • DRENICK EJ, FISLER J, JOHNSON D: Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazol, irrespective of protein-calorie malnutrition. Gastroenterology (1982) 82:535-548.
    • (1982) Gastroenterology , vol.82 , pp. 535-548
    • Drenick, E.J.1    Fisler, J.2    Johnson, D.3
  • 34
    • 0026505861 scopus 로고
    • Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition in rats
    • BUCHMAN AL, DUBIN M, JENDEN D et al.: Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition in rats. Gastroenterology (1992) 102:1363-1370.
    • (1992) Gastroenterology , vol.102 , pp. 1363-1370
    • Buchman, A.L.1    Dubin, M.2    Jenden, D.3
  • 35
    • 0028789050 scopus 로고
    • Choline deficiency: A cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline Supplementation
    • BUCHMAN AL, DUBIN MD, MOUKARZEL AA et al.: Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline Supplementation. Hepatology (1995) 22:1390-1403.
    • (1995) Hepatology , vol.22 , pp. 1390-1403
    • Buchman, A.L.1    Dubin, M.D.2    Moukarzel, A.A.3
  • 36
    • 0026059003 scopus 로고
    • Polymixin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in rat
    • PAPPO I, BECOVIER H, BERRY EM, FREUD HR: Polymixin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in rat. J. Sur. Res. (1991) 51:106-112.
    • (1991) J. Sur. Res. , vol.51 , pp. 106-112
    • Pappo, I.1    Becovier, H.2    Berry, E.M.3    Freud, H.R.4
  • 38
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin
    • Diabetes prevention program research group
    • Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin. Diabetes prevention program research group. N. Engl. J. Med. (2002) 346:393-403.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
  • 41
    • 0032727659 scopus 로고    scopus 로고
    • Thiazolidinediones: A new class of antidiabetic drugs
    • DAY C: Thiazolidinediones: a new class of antidiabetic drugs. Diabet. Med. (1999) 16:179-192.
    • (1999) Diabet. Med. , vol.16 , pp. 179-192
    • Day, C.1
  • 43
    • 0032568261 scopus 로고    scopus 로고
    • Hepatic dysfunction associated with troglitazone
    • WATKINS PB, WHITCOMB RW: Hepatic dysfunction associated with troglitazone. N. Engl. J. Med. (1998) 338:908-909.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 908-909
    • Watkins, P.B.1    Whitcomb, R.W.2
  • 44
    • 0038149944 scopus 로고    scopus 로고
    • Histological improvement in NASH following reduction of insulin resistance with 48-week treatment with the PPAγ agonist rosiglitazone
    • (Abtract)
    • NEUSCHWANDER-TETRI BA, BRUNT EM, BACON BR et al.: Histological improvement in NASH following reduction of insulin resistance with 48-week treatment with the PPAγ agonist rosiglitazone. Hepatology (2002) 36:379A (Abtract).
    • (2002) Hepatology , vol.36
    • Neuschwander-tetri, B.A.1    Brunt, E.M.2    Bacon, B.R.3
  • 45
    • 0038132644 scopus 로고    scopus 로고
    • The use of pioglitazone in nonalcoholic steatohepatitis
    • (Abstract)
    • ACOSTA RC, MOLINA EG, O'BRIEN CB et al.: The use of pioglitazone in nonalcoholic steatohepatitis. Gastroenterology (2001) 120(Suppl.):2778 (Abstract).
    • (2001) Gastroenterology , vol.120 , Issue.SUPPL. , pp. 2778
    • Acosta, R.C.1    Molina, E.G.2    O'brien, C.B.3
  • 46
    • 0037794933 scopus 로고    scopus 로고
    • A randomized controlled pilot study or pioglitazone and vitamin E versus vitamin E for nonalcoholic steatohepatitis
    • (Abstract)
    • SANYAL AJ, CONTOS MJ, SARGEANT C et a.: A randomized controlled pilot study or pioglitazone and vitamin E versus vitamin E for nonalcoholic steatohepatitis. Hepatology (2002) 36:382A (Abstract).
    • (2002) Hepatology , vol.36
    • Sanyal, A.J.1    Contos, M.J.2    Sargeant, C.3
  • 47
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in non-alcoholic steatohepatitis
    • MARCHESINI G, BRIZI M, BIANCHI G et al.: Metformin in non-alcoholic steatohepatitis. Lancet (2001) 358:893-894.
    • (2001) Lancet , vol.358 , pp. 893-894
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 48
    • 0038826548 scopus 로고    scopus 로고
    • Metformin in nonalcoholic steatohepatitis (NASH): Efficacy and safety: A preliminary report
    • (Abstract)
    • NAIR S, DIEHL AM, PERRILLO R: Metformin in nonalcoholic steatohepatitis (NASH): efficacy and safety: a preliminary report. Gastroenterology (2002) 122(Suppl.):4 (Abstract).
    • (2002) Gastroenterology , vol.122 , Issue.SUPPL. 4
    • Nair, S.1    Diehl, A.M.2    Perrillo, R.3
  • 49
    • 0030854425 scopus 로고    scopus 로고
    • A pilot study of the effects of d-α-tocopherol on hepatic stellate cell activation in chronic hepatitis C
    • HOUGLUM K, VENKATARAMANI A, LYCHE K, CHOJKIER M: A pilot study of the effects of d-α-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology (1997) 113:1069-1073.
    • (1997) Gastroenterology , vol.113 , pp. 1069-1073
    • Houglum, K.1    Venkataramani, A.2    Lyche, K.3    Chojkier, M.4
  • 50
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • LAVINE JE: Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J. Pediat. (2000) 136:734-738.
    • (2000) J. Pediat. , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 51
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-β1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • HASEGAWA T, YONEDA M, NAKAMURA K, MAKINO I, TERANO A: Plasma transforming growth factor-β1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment. Pharmacol. Ther. (2001) 15:1667-1672.
    • (2001) Aliment. Pharmacol. Ther. , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 52
    • 0038488574 scopus 로고    scopus 로고
    • Vitamin E and vitamin C in the treatment of nonalcoholic steatohepatitis. A prospective, randomized, placebo-controlled clinical trial. A preliminary report
    • (Abstract)
    • HARRISON SA, KADAKIA S, TORGERSON S et al.: Vitamin E and vitamin C in the treatment of nonalcoholic steatohepatitis. A prospective, randomized, placebo-controlled clinical trial. A preliminary report. Gastroenterology (2002) 122(Suppl.):M1332 (Abstract).
    • (2002) Gastroenterology , vol.122 , Issue.SUPPL.
    • Harrison, S.A.1    Kadakia, S.2    Torgerson, S.3
  • 53
    • 0027318064 scopus 로고
    • Dietary betaine promotes generation of hepatitic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration
    • BARAK AJ, BECKENHAUER HC, JUNNILA M, TUMA DJ: Dietary betaine promotes generation of hepatitic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol. Clin. Exp. Res. (1993) 17:552-555.
    • (1993) Alcohol. Clin. Exp. Res. , vol.17 , pp. 552-555
    • Barak, A.J.1    Beckenhauer, H.C.2    Junnila, M.3    Tuma, D.J.4
  • 54
    • 0034834208 scopus 로고    scopus 로고
    • Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study
    • ABDELMALEK M, ANGULO P, JORGENSEN RA, SYLVESTRE P, LINDOR KD: Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am. J. Gastroenterol. (2001) 96:2711-2717.
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 2711-2717
    • Abdelmalek, M.1    Angulo, P.2    Jorgensen, R.A.3    Sylvestre, P.4    Lindor, K.D.5
  • 55
    • 0033884107 scopus 로고    scopus 로고
    • Efficacy and safety of oral betaine glucurontae in nonalcoholic steatohepatitis
    • MIGLIO F, ROVATI LC, SANTORO A, SETKIKAR I: Efficacy and safety of oral betaine glucurontae in nonalcoholic steatohepatitis. Arzneim. Forsch. (2000) 50(2):722-727.
    • (2000) Arzneim. Forsch. , vol.50 , Issue.2 , pp. 722-727
    • Miglio, F.1    Rovati, L.C.2    Santoro, A.3    Setkikar, I.4
  • 56
    • 0000953246 scopus 로고    scopus 로고
    • Treatment of non-alcoholic steatohepatitis with N-acetylcysteine
    • (Abstract)
    • GULBAHAR O, KARASU ZA, ERSOZ G, AKARCA US, MUSOGLU A: Treatment of non-alcoholic steatohepatitis with N-acetylcysteine. Gastroenterology (2000) 118(Part 2 Suppl.):6550 (Abstract).
    • (2000) Gastroenterology , vol.118 , Issue.PART 2 SUPPL. , pp. 6550
    • Gulbahar, O.1    Karasu, Z.A.2    Ersoz, G.3    Akarca, U.S.4    Musoglu, A.5
  • 57
    • 0037812264 scopus 로고    scopus 로고
    • Phlebotomy reduces transaminase levels in patients with chronic non-viral non-alcoholic steatohepatitis
    • (Abstract)
    • DESAI TK: Phlebotomy reduces transaminase levels in patients with chronic non-viral non-alcoholic steatohepatitis Hepatology (1996) 24(Part 2 Suppl.):1498 (Abstract).
    • (1996) Hepatology , vol.24 , Issue.PART 2 SUPPL. , pp. 1498
    • Desai, T.K.1
  • 58
    • 0000679912 scopus 로고    scopus 로고
    • Phlebotomy reduces transaminase levels in patients with non-alcoholic steatohepatitis
    • (Abstract)
    • DESAI TK: Phlebotomy reduces transaminase levels in patients with non-alcoholic steatohepatitis. Gastroenterology (2000) 118(Part 1 Suppl. 2):1071 (Abstract).
    • (2000) Gastroenterology , vol.118 , Issue.PART 1 SUPPL. 2 , pp. 1071
    • Desai, T.K.1
  • 59
    • 0000439294 scopus 로고    scopus 로고
    • Effect of phlebotomy on non-alcoholic steatohepatitis (NASH)
    • (Abstract)
    • NITECKI J, JACKSON FW, ALLEN ML, FARR VL, JACKSON FW: Effect of phlebotomy on non-alcoholic steatohepatitis (NASH). Gastroenterology (2000) 118(Part 2 Suppl. 2):6679 (Abstract).
    • (2000) Gastroenterology , vol.118 , Issue.PART 2 SUPPL. 2 , pp. 6679
    • Nitecki, J.1    Jackson, F.W.2    Allen, M.L.3    Farr, V.L.4    Jackson, F.W.5
  • 60
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • FACCHINI FS, HUA NW, STOOHS RA: Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology (2002) 122:931-939.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 61
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: A pilot study
    • LAURIN J, LINDOR KD, CRIPPIN JS et al.: Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: A pilot study. Hepatology (1996) 23:1464-1467.
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippin, J.S.3
  • 62
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • BASARANOGLU M, ACBAY O, SONSUZ A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J. Hepatol. (1999) 31:384.
    • (1999) J. Hepatol. , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 64
    • 0036480219 scopus 로고    scopus 로고
    • Use of ursodeoxycholic acid in patients with liver disease
    • ANGULO P: Use of ursodeoxycholic acid in patients with liver disease. Current Gastrioenterol. Rep. (2002) 4:37-44.
    • (2002) Current Gastrioenterol. Rep. , vol.4 , pp. 37-44
    • Angulo, P.1
  • 65
    • 1542671564 scopus 로고    scopus 로고
    • Fat-laden hepatocytes are more prone to cellular necrosis than apoptosis when exposed to hydrophobic bile acids
    • KOBAK GE, DEUTSCH G, DAHL R, DEVEREAUX MW, GUMPRICHT E, SOKOL RJ: Fat-laden hepatocytes are more prone to cellular necrosis than apoptosis when exposed to hydrophobic bile acids. Gastroenterology (2002) 122(Suppl. 1):411.
    • (2002) Gastroenterology , vol.122 , Issue.SUPPL. 1 , pp. 411
    • Kobak, G.E.1    Deutsch, G.2    Dahl, R.3    Devereaux, M.W.4    Gumpricht, E.5    Sokol, R.J.6
  • 66
    • 0001083778 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis: Results of a prospective clinical controlled trial
    • (Abstract)
    • GUMA C, VIOLA L, THOME M, GALDAME O, ALVAREZ E: Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis: results of a prospective clinical controlled trial. Hepatology (1997) 26(Part 2 Suppl.):1036 (Abstract).
    • (1997) Hepatology , vol.26 , Issue.PART 2 SUPPL. , pp. 1036
    • Guma, C.1    Viola, L.2    Thome, M.3    Galdame, O.4    Alvarez, E.5
  • 67
    • 0000685882 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid plus diet in patients with non-alcoholic steatohepatitis
    • (Abstract)
    • CERIANI R, BUNATI S, MORINI L, SACCHI E, COLOMBO G: Effect of ursodeoxycholic acid plus diet in patients with non-alcoholic steatohepatitis. Hepatology (1998) 28(Part 2 Suppl.):894 (Abstract).
    • (1998) Hepatology , vol.28 , Issue.PART 2 SUPPL. , pp. 894
    • Ceriani, R.1    Bunati, S.2    Morini, L.3    Sacchi, E.4    Colombo, G.5
  • 68
    • 0004385359 scopus 로고    scopus 로고
    • Serum markers of liver fibrosis in patients with non-alcoholic steatohepatitis (NASH). Correlation to liver morphology and effect of therapy
    • (Abstract)
    • HOLOMAN J, GLASA J, KASAR J et al.: Serum markers of liver fibrosis in patients with non-alcoholic steatohepatitis (NASH). Correlation to liver morphology and effect of therapy. J. Hepatol. (2000) 32(Suppl. 2):210 (Abstract).
    • (2000) J. Hepatol. , vol.32 , Issue.SUPPL. 2 , pp. 210
    • Holoman, J.1    Glasa, J.2    Kasar, J.3
  • 69
    • 0034049790 scopus 로고    scopus 로고
    • Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children
    • VAJRO P, FRANZE A, VALERIO G, IANNUCCI MP, ARAGIONE N: Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children. J. Pediatr. (2000) 136:739-743.
    • (2000) J. Pediatr. , vol.136 , pp. 739-743
    • Vajro, P.1    Franze, A.2    Valerio, G.3    Iannucci, M.P.4    Aragione, N.5
  • 70
    • 0034925012 scopus 로고    scopus 로고
    • Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease
    • CHARLTON M, KASPAROVA P, WESTON S et al.: Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease. Liver Transpl. (2001) 7:608-614.
    • (2001) Liver Transpl. , vol.7 , pp. 608-614
    • Charlton, M.1    Kasparova, P.2    Weston, S.3
  • 71
    • 0035052345 scopus 로고    scopus 로고
    • Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis
    • CONTOS MJ, CALES W, STERLING RK et al.: Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl (2001) 7:363-373.
    • (2001) Liver Transpl. , vol.7 , pp. 363-373
    • Contos, M.J.1    Cales, W.2    Sterling, R.K.3
  • 72
    • 0342716457 scopus 로고    scopus 로고
    • Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice
    • LETTERSON P, FROMENTY B, TERRIS B, DEGOTT C, PASSAYRE D: Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. J. Hepatol. (1996) 24:200-208.
    • (1996) J. Hepatol. , vol.24 , pp. 200-208
    • Letterson, P.1    Fromenty, B.2    Terris, B.3    Degott, C.4    Passayre, D.5
  • 73
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • WELTMAN MD, FARRELL GC, LIDDLE C: Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology (1996) 111:1645-1653.
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 75
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • WELTMAN MD, FARREL GC, HALL P, INGELMAN-SUNDBERG M, LIDDLE C: Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology (1998) 27:128-133.
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrel, G.C.2    Hall, P.3    Ingelman-sundberg, M.4    Liddle, C.5
  • 76
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • YANG SQ, LIN HZ, LANE MD, CLEMENS M, DIEHL AM: Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc. Natl. Acad. Sci. USA (1997) 94:2557-2562.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 77
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibits inflammatory activity and improves nonalcoholic fatty liver disease
    • LI Z, YANG S, LIN H et al.: Probiotics and antibodies to TNF inhibits inflammatory activity and improves nonalcoholic fatty liver disease. Hepatology (2003) 37:343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 78
    • 0033605261 scopus 로고    scopus 로고
    • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
    • CHAVIN KD, YANG SQ, LIN HZ et al.: Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Bio. Chem. (1999) 274:5692-5700.
    • (1999) J. Bio. Chem. , vol.274 , pp. 5692-5700
    • Chavin, K.D.1    Yang, S.Q.2    Lin, H.Z.3
  • 79
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatoheaptitis. A pilot study
    • CORTEZ-PINTO H, CHATHAM J, CHACKO VP, ARNOL C, RASHID A, DIEHL AM: Alterations in liver ATP homeostasis in human nonalcoholic steatoheaptitis. A pilot study. JAMA (1999) 282:1659-1664.
    • (1999) JAMA , vol.282 , pp. 1659-1664
    • Cortez-pinto, H.1    Chatham, J.2    Chacko, V.P.3    Arnol, C.4    Rashid, A.5    Diehl, A.M.6
  • 80
    • 4243670897 scopus 로고    scopus 로고
    • Health-related quality of life assessment in nonalcoholic steatohepatitis
    • (Abstract)
    • TALWALKAR J, KEACH J, ANGULO P, LINDOR KD: Health-related quality of life assessment in nonalcoholic steatohepatitis. Hepatology (2001) 34(Suppl.):309A (Abstract).
    • (2001) Hepatology , vol.34 , Issue.SUPPL.
    • Talwalkar, J.1    Keach, J.2    Angulo, P.3    Lindor, K.D.4
  • 81
    • 4243447312 scopus 로고    scopus 로고
    • Health state preferences among patients with nonalcoholic steatohepatitis
    • (Abstract)
    • TALWALKAR AJ, DONLINGER JJ, GOSSARD AA, LINDOR KD: Health state preferences among patients with nonalcoholic steatohepatitis. Hepatology (2002) 36(Suppl.):382A (Abstract).
    • (2002) Hepatology , vol.36 , Issue.SUPPL.
    • Talwalkar, A.J.1    Donlinger, J.J.2    Gossard, A.A.3    Lindor, K.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.