Thermodynamic analysis of binding and protonation in DOTAP/DOPE (1:1): DNA complexes using isothermal titration calorimetry

Biophysical Chemistry

Volumn 104, Issue 1, 2003, Pages 67-78

  Lobo, Brian A ^a   Koe, Gary S ^b   Koe, Janet G ^b   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Urigen Pharmaceuticals Inc   (United States)

Author keywords

Cationic lipid; DOPE; Isothermal titration calorimetry; Plasmid DNA; Proton linkage; Protonation

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AMMONIUM DERIVATIVE; BUFFER; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DNA; LIPOSOME; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCULATION; CALORIMETRY; COMPLEX FORMATION; ENTHALPY; ENTROPY; IONIC STRENGTH; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTON TRANSPORT; THERMODYNAMICS;

BINDING SITES; BUFFERS; CALORIMETRY; CATIONS; DNA; FATTY ACIDS, MONOUNSATURATED; HYDROGEN-ION CONCENTRATION; LIPIDS; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; PROTONS; QUATERNARY AMMONIUM COMPOUNDS; THERMODYNAMICS;

EID: 0038016473     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(02)00339-3     Document Type: Article

References (31)

1. Pierce M., Raman C., Nall B. Isothermal titration calorimetry of protein-protein interactions. Meth. Enzymol. 19:1999;213-221.
2. Seelig J. Titration calorimetry of lipid-peptide interactions. Biochim. Biophys. Acta. 1331:1997;103-116.
3. Breslauer K., Freire E., Straume M. Calorimetry: a tool for DNA and ligand-DNA studies. Meth. Enzymol. 211:1992;533-567.
4. Baerreleiro P., Olofsson G., Alexandridis P. Interaction of DNA with cationic vesicles: a calorimetric study. J. Phys. Chem. B. 104:2000;7795-7802.
5. Pector V., Backmann J., Maes D., Vandenbranden M., Ruysschaert J.-M. Biophysical and Structural Properties of DNA-di C14-amidine Complexes. J. Biol. Chem. 275:2000;29533-29538.
6. E. Pozharski, R. MacDonald, Thermodynamics of cationic lipid-DNA complex formation as studied by isothermal titration calorimetry, Biophys J 83, (2002).
7. Lobo B., Davis A., Koe G., Smith J., Middaugh C. Isothermal titration calorimetric analysis of the interaction between cationic lipids and plasmid DNA. Arch. Biochem. Biophys. 386:2001;95-105.
8. Kennedy M., Pozharski E., Rakhmanova V., MacDonald R. Factors governing the assembly of cationic phospholipid-DNA complexes. Biophys. J. 78:2000;1620-1633.
9. Stegmann T., Legendre J. Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection. Biochim. Biophys. Acta. 1325:1997;71-79.
10. Ferrari M., Rusalov D., Enas J., Wheeler C. Trends in lipoplex physical properties dependent on cationic lipid structure, vehicle and complexation procedure do not correlate with biological activity. Nucl. Acids Res. 29:2001;1539-1548.
11. Felgner J., Kukmar R., Sridhar C., Wheeler C., Tsai Y., Border R., et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269:1994;2550-2561.
12. Tatulian S. Cevc G. Phospholipid Handbook, Ionization and ion binding. 1993;511-553 Marcell Dekker, New York.
13. Wyman J. Binding linkage and reciprocal effects in hemoglobin: a second look. Adv. Protein Chem. 19:1964;223-286.
14. Wyman J., Gill S.J. Binding and linkage: functional chemistry of biological macromolecules. 1990;University Science Books, Mill Valley, CA.
15. Xie D., Gulnik S., Collins L., Gustchina E., Suvorov L., Erickson J. Dissection of the pH dependence of inhibitor binding energetics for an aspartic protease:direct measurement of the protonation states of the catalytic aspartic acid residues. Biochemistry. 36:1997;16166-16172.
16. Baker B., Murphy K. Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry. Biophys. J. 71:1996;2049-2055.
17. Crnogorac M., Ullmann G., Kostic N. Effects of pH on protien association: modification of the proton-linkage model and experimental verification of the modified model in the case of cytochrome c and plastocyanin. J. Am. Chem. Soc. 123:2001;10789-10798.
18. Bradshaw J., Waksman G. Calorimetric investigation of proton linkage by monitoring both the enthalpy and association constant of binding: application to the interaction of the Src SH2 domain with a high-affinity tyrosyl phosphopeptide. Biochemistry. 37:1998;15400-15407.
19. Bolen D.W., Slightom J.L. Calorimetric determination of linkage effects involving an acyl-enzyme intermediate. Biophys. Chem. 37:1990;303-312.
20. von Harpe A., Petersen H., Li Y., Kissel T. Characterization of commercially available and synthesized polyethylenimines for gene delivery. J. Control. Release. 69:2000;309-322.
21. Beschiaschvili G., Seelig J. Peptide binding to lipid bilayers. Non-classical hydrophobic effect and membrane-induced pK Shifts. Biochemistry. 31:1992;10044-10053.
22. Martin B. Introduction to Biophysical Chemistry. 1964;McGraw-Hill, New York.
23. Christensen J., Hansen L., Izatt R. Handbook of proton ionization heats and related thermodynamic quantities. 1976;John Wiley and Sons, New York.
24. Cooper A., Johnson C. Mulloy B., Jones C., Thomas A.H. Microscopy, Optical Spectroscopy, and Macroscopic Techniques, Introduction to Microcalorimetry and Biomolecular Energetics. 1994;Humana Press Inc, Totowa, NJ.
25. Mortimer C. Reaction Heats and Bond Strengths. 1962;Pergamon Press, Reading, MA.
26. Bloomfield V., Crothers D., Tinoco I. Nucleic Acids: Structures, Properties and Functions. 2000;University Science Books, Sausalito, CA.
27. Ross P.D., Subramanian S. Thermodynamics of protein association reactions: forces contributing to stability. Biochemistry. 20:1981;3096-3102.
28. McGraw S.E., Lindenbaum S. The use of microcalorimetry to measure thermodynamic parameters of the binding of ligands to insulin. Pharm. Res. 7:1990;606-611.
29. Zuidam N.J., Barenholz Y. Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin. Biochim. Biophys. Acta. 1329:1997;211-222.
30. Zuidam N.J., Barenholz Y. Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery. Biochim. Biophys. Acta. 1368:1998;115-128.
31. Zuidam N.J., Barenholz Y. Characterization of DNA-lipid complexes commonly used for gene delivery. Int. J. Pharm. 183:1999;43-46.