Proliferative activities of tumor stromal cells play important roles in tumor thickness and progression of T3 ulcerative-type colorectal cancer

Virchows Archiv

Volumn 442, Issue 6, 2003, Pages 569-576

  Hasebe, Takahiro ^a   Sasaki, Satoshi ^a   Sugitoh, Masanori ^b   Ono, Masato ^b   Saitoh, Norio ^b   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Colorectal cancer; Endothelial cell; Fibroblast; Prognosis; Proliferative activity

Indexed keywords

ARTICLE; CANCER CLASSIFICATION; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; EVALUATION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; STROMA CELL; TUMOR CELL; TUMOR GROWTH;

EID: 0038008281     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-003-0811-5     Document Type: Article

References (24)

1. Afzal S, Lalani EN, Poulsom R, et al (1998) MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts. Hum Pathol 29:155-165
2. Booth C, Harnden P, Trejdosiewicz LK, et al (1997) Stromal and vascular invasion in a human in vitro bladder cancer model. Lab Invest 76:843-857
3. Cox DR (1972) Regression models and life-tables. J R Stat Soc 34:187-220
4. Dershaw DD, Enker WE, Cohen AM, Sigurdson ER (1990) Transrectal ultrasonography of rectal carcinoma. Cancer 66:2336-2340
5. Dukes CE (1932) The classification of cancer of the rectum. J Pathol Bacteriol 35:323-332
6. Fox SB, Gatter KC, Bicknell R, et al (1993) Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res 53:4161-4163
7. Hasebe T, Morihiro M, Sasaki S, Shimoda T, Sugitoh M, Moriya Y, Ono M, Arai T, Ochiai A (2000) Tumor thickness is a histopathological predictive parameter of tumor metastasis and prognosis in Dukes C ulcerative-type colorectal cancer patients: two-hospital based study. Cancer 89:35-45
8. Hasebe T, Sasaki S, Imoto S, Ochiai A (2000) Proliferative activity of intratumoral fibroblasts is closely correlated with lymph node and distant organ metastasis of invasive ductal carcinoma of the breast. Am J Pathol 156:1701-1710
9. Hasebe T, Sasaki S, Sugitoh M, Ono M, Saitoh N, Ochiai A (2001) Highly proliferative intratumoral fibroblasts and a high proliferative microvessel index are significant predictor of tumor metastasis in T3 ulcerative-type colorectal cancer. Hum Pathol 32:401-409
10. Horak ER, Leek R, Klenk N, Lejeune S, et al (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet 340:1120-1124
11. Hornig C, Barleon B, Ahmad S, et al (2000) Release and complex formation of soluble VEGFR-1 from endothelial cells and biological fluids. Lab Invest 80:443-454
12. Hsu SM, Soban E (1982) Color modification of diaminobenzidine (DAB) precipitation by metallic irons and its application for double immunohistochemistry. J Histochem Cytochem 30:1079-1082
13. Jass JR, Sobin LH (1989) Histological typing of intestinal tumors, 2nd edn. Springer, Berlin Heidelberg New York
14. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
15. Kimmey MB, Martin RW, Haggitt RC, et al (1989) Histologic correlates of gastrointestinal ultrasound images. Gastroenterol 96:433-441
16. Morson BC, Dawson IMP (1990) Morson & Dawson's gastrointestinal pathology, 3rd edn. Blackwell, Oxford, pp 607
17. Nagia-Makker P, Honjo Y, Sarvis R, et al (2000) Galectin-3 induces endothelial cell morphogenesis and angiogenesis. Am J Pathol 156:899-909
18. Noel A, Hajitou A, L'Hoir C, et al (1998) Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts. Int J Cancer 76:267-273
19. Parums DV, Cordell JL, Micklem K, et al (1990) JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 43:752-757
20. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1-39
21. Rosai J (1996) Surgical pathology, 3rd edn. Mosby, St. Louis, pp 769
22. Shi SR, Key ME, Kalza KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39:741-746
23. Uría JA, Stahle-Bäckdahl M, Seiki M, et al (1997) Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions. Cancer Res 57:4882-4888
24. Vartanian RK, Weidner N (1994) Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Am J Pathol 144:1188-1194