Telomere length and the expression of natural telomeric genes in human fibroblasts

Human Molecular Genetics

Volumn 12, Issue 11, 2003, Pages 1329-1336

  Ning, Yi ^a   Xu, Jing Fan ^a   Li, Yu ^b   Chavez, Liz ^c   Riethman, Harold C ^d   Lansdorp, Peter M ^c   Weng, Nan Ping ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIVISION; CHROMATIN STRUCTURE; CONTROLLED STUDY; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; HETEROCHROMATIN; HUMAN; HUMAN CELL; HYPOTHESIS; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TELOMERE; TRANSCRIPTION REGULATION;

CELL AGING; CELLS, CULTURED; CHROMOSOMES, HUMAN; FIBROBLASTS; GENE EXPRESSION REGULATION; HETEROCHROMATIN; HUMANS; TELOMERE;

EID: 0038006763     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg139     Document Type: Article

References (28)

1. Kim, S.H., Kaminker, P. and Campisi, J. (2002) Telomeres, aging and cancer: in search of a happy ending. Oncogene, 21, 503-511.
2. Shay, J.W. and Wright, W.E. (1992) Telomere positional effects and the regulation of cellular senescence. Trends Genet., 8, 193-197.
3. Tham, W.H. and Zakian, V.A. (2002) Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene, 21, 512-521.
4. Bayne, R.A., Broccoli, D., Taggart, M.H., Thomson, E.J., Farr, C.J. and Cooke, H.J. (1994) Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing. Hum. Mol. Genet., 3, 539-546.
5. Sprung, C.N., Sabatier, L. and Murnane, J.P. (1996) Effect of telomere length on telomeric gene expression. Nucl. Acids Res., 24, 4336-4340.
6. Ofir, R., Wong, A.C., McDermid, H.E., Skorecki, K.L. and Selig, S. (1999) Position effect of human telomeric repeats on replication timing. Proc. Natl Acad. Sci. USA, 96, 11434-11439.
7. Baur, J.A., Zou, Y., Shay, J.W. and Wright, W.E. (2001) Telomere position effect in human cells. Science, 292, 2075-2077.
8. Koering, C.E., Pollice, A., Zibella, M.P., Bauwens, S., Puisieux, A., Brunori, M., Brun, C., Martins, L., Sabatier, L., Pulitzer, J.F. et al. (2002) Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep., 3, 1055-1061.
9. Blackburn, E.H. (2001) Switching and signaling at the telomere. Cell, 106, 661-673.
10. Flint, J., Bates, G.P., Clark, K., Dorman, A., Willingham, D., Roe, B.A., Micklem, G., Higgs, D.R. and Louis, E.J. (1997) Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains. Hum. Mol. Genet., 6, 1305-1313.
11. Riethman, H.C., Xiang, Z., Paul, S., Morse, E., Hu, X.L., Flint, J., Chi, H.C., Grady, D.L. and Moyzis, R.K. (2001) Integration of telomere sequences with the draft human genome sequence. Nature, 409, 948-951.
12. Robetorye, R.S., Nakanishi, M., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1996) Regulation of p21Sdi1/Waf1/Cip1mda6- and expression of other cyclin-dependent kinase inhibitors in senescent human cells. Mol. Cell. Different., 4, 113-126.
13. Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res., 211, 90-98.
14. Fang, L., Igarashi, M., Leung, J., Sugrue, M.M., Lee, S.W. and Aaronson, S.A. (1999) p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene, 18, 2789-2797.
15. Lansdorp, P.M., Verwoerd, N.P., van de Rijke, F.M., Dragowska, V., Little, M.T., Dirks, R.W., Raap, A.K. and Tanke, H.J. (1996) Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet., 5, 685-691.
16. Martens, U.M., Chavez, E.A., Poon, S.S., Schmoor, C. and Lansdorp, P.M. (2000) Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res., 256, 291-299.
17. Renauld, H., Aparicio, O.M., Zierath, P.D., Billington, B.L., Chhablani, S.K. and Gottschling, D.E. (1993) Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev., 7, 1133-1145.
18. Chan, S.W. and Blackburn, E.H. (2002) New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene, 21, 553-563.
19. Rubio, M.A., Kim, S.H. and Campisi, J. (2002) Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J. Biol. Chem., 277, 28609-28617.
20. Flint, J., Thomas, K., Micklem, G., Raynham, H., Clark, K., Doggett, N.A., King, A. and Higgs, D.R. (1997) The relationship between chromosome structure and function at a human telomeric region. Nat. Genet., 15, 252-257.
21. Pryde, F.E. and Louis, E.J. (1999) Limitations of silencing at native yeast telomeres. EMBO J., 18, 2538-2550.
22. Dimri, G.P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E.E., Linskens, M., Rubelj, I., Pereira-Smith, O. et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA, 92, 9363-9367.
23. Pignolo, R.J., Cristofalo, V.J. and Rotenberg, M.O. (1993) Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state. J. Biol. Chem., 268, 8949-8957.
24. Li, S., MacLachlan, T.K., De Luca, A., Claudio, P.P., Condorelli, G. and Giordano, A. (1995) The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res., 55, 3992-3995.
25. Schneider, C., King, R.M. and Philipson, L. (1988) Genes specifically expressed at growth arrest of mammalian cells. Cell, 54, 787-793.
26. Whitmore, S.A., Settasatian, C., Crawford, J., Lower, K.M., McCallum, B., Seshadri, R., Cornelisse, C.J., Moerland, E.W., Cleton-Jansen, A.M., Tipping, A.J. et al. (1998) Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. Genomics, 52, 325-331.
27. Powell, J.A., Gardner, A.E., Bais, A.J., Hinze, S.J., Baker, E., Whitmore, S., Crawford, J., Kochetkova, M., Spendlove, H.E., Doggett, N.A. et al. (2002) Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. Genomics, 80, 303-310.
28. Itahana, K., Dimri, G.P., Hara, E., Itahana, Y., Zou, Y., Desprez, P.Y. and Campisi, J. (2002) A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J. Biol. Chem., 277, 18206-18214.