Isolation, structure, and HIV-1 integrase inhibitory activity of cytosporic acid, a fungal metabolite produced by a Cytospora sp.

Journal of Natural Products

Volumn 66, Issue 4, 2003, Pages 551-553

  Jayasuriya, Hiranthi ^a,b   Guan, Ziqiang ^a,b   Polishook, Jon D ^a,b   Dombrowski, Anne W ^a,b   Felock, Peter J ^a,b   Hazuda, Daria J ^a,b   Singh, Sheo B ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSPORIC ACID; INTEGRASE; NATURAL PRODUCT; POLYKETIDE; UNCLASSIFIED DRUG;

ARTICLE; CYTOSPORA; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FUNGUS; IC 50; METABOLITE; NONHUMAN; PUERTO RICO; STEREOCHEMISTRY;

ELECTRON SPIN RESONANCE SPECTROSCOPY; FERMENTATION; FUNGI; HIV INTEGRASE INHIBITORS; HIV-1; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PUERTO RICO; STEREOISOMERISM; TETRAHYDRONAPHTHALENES;

CYTOSPORA; FUNGI; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037998205     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np020533g     Document Type: Article

References (14)

1. For recent reviews on HIV integrase, see: (a) Craigie, R. J. Biol. Chem. 2001, 276, 23213-23216. (b) Esposito, D.; Craigie, R. Adv. Virus Res. 1999, 52, 319-333.
2. For recent reviews on HIV integrase, see: (a) Craigie, R. J. Biol. Chem. 2001, 276, 23213-23216. (b) Esposito, D.; Craigie, R. Adv. Virus Res. 1999, 52, 319-333.
3. (a) Hazuda, D. J.; Felock, P.; Witmer, M.; Wolfe, A.; Stillmock, K.; Grobler, J. A.; Espeseth, A.; Gabryelski, L.; Schleif, W.; Blau, C.; Miller, M. D. Science 2000, 287, 646-650.
4. (b) Wai, J. S.; Egbertson, M. S.; Payne, L. S.; Fisher, T. E.; Embrey, M. W.; Tran, L. O.; Melamed, J. Y.; Langford, H. M.; Guare, J. P.; Zhuang, L.; Grey, V. E.; Vacca, J. P.; Holloway, M. K.; Naylor-Olsen, A. M.; Hazuda, D. J.; Felock, P. J.; Wolfe, A. L.; Stillmock, K. A.; Schleif, W.; Gabryelski, L. J.; Young, S. D. J. Med. Chem. 2000, 43, 4923-4926.
5. (c) Neamati, N. Exp. Opin. Invest. Drugs 2001, 10, 281-296.
6. Young, S. D. In HIV Drug Resistance International Workshop, Seville, Spain (July 2-5, 2002).
7. Singh, S. B.; Zink, D. L.; Goetz, M. A.; Dombrowski, A. W.; Polishook, J. D.; Hazuda, D. L. Tetrahedron Lett. 1998, 39, 2243-2246.
8. (b) Hazuda, D.; Blau, C. U. C.; Felock, P.; Hastings, J.; Pramanik, B.; Wolfe, A.; Bushman, F.; Farnet, C.; Goetz, M.; Williams, M.; Silverman, K.; Lingham, R.; Singh, S. Antiviral Chem. Chemother. 1999, 10, 63-70.
9. Singh, S. B.; Herath, K.; Guan, Z.; Zink, D. L.; Dombrowski, A. W.; Polishook, J. D.; Silverman, K. C.; Lingham, R. B.; Felock, P.; Hazuda, D. J. Org. Lett. 2002, 4, 1431-1434.
10. Hensens, O. D.; Helms, G. L.; Jones, E. T. T.; Harris, G. H. J. Org. Chem. 1995, 60, 1772-1776.
11. Singh, S. B.; Zink, D. L.; Liesch, J. M.; Moseley, R. T.; Dombrowski, A. W.; Bills, G. F.; Darkin-Rattray, S. J.; Schmatz, D. M.; Goetz, M. A. J. Org. Chem. 2002, 67, 815-825.
12. Sutton, B. C. The Coelomycetes; Commonwealth Mycological Institute: Kew, Surrey, England, 1980.
13. Dombrowski, A.; Jenkins, R.; Raghoobar, S.; Bills, G.; Polishook, J.; Pelaez, F.; Burgess, B.; Zhao, A.; Huang, L.; Zhang, Y.; Goetz, M. J. Antibiot. 1999, 52, 1077-1085.
14. Singh, S. B.; Smith, J. L.; Sabnis, G. S.; Dombrowski, A. W.; Schaefer, J. M.; Goetz, M. A.; Bills, G. F. Tetrahedron 1991, 47, 6931-6938.