Extracellular glutamine to glutamate ratio may predict outcome in the injured brain: A clinical microdialysis study in children

Pharmacological Research

Volumn 48, Issue 1, 2003, Pages 101-109

  Richards, Douglas A ^a   Tolias, Christos M ^b   Sgouros, Spyros ^b   Bowery, Norman G ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Excitotoxicity; Glutamate; Glutamine; Head injury; Microdialysis

Indexed keywords

AMINO ACID; GLUTAMIC ACID; GLUTAMINE;

ADOLESCENT; AMINO ACID BRAIN LEVEL; ARTICLE; BRAIN INJURY; CELL DAMAGE; CELL MEMBRANE; CHILD; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DISEASE ASSOCIATION; EXTRACELLULAR SPACE; FEMALE; HOMEOSTASIS; HUMAN; INTRACRANIAL PRESSURE; MALE; MEASUREMENT; METHODOLOGY; MICRODIALYSIS; PILOT STUDY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SAMPLE;

EID: 0037951491     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(03)00081-1     Document Type: Article

References (34)

1. Finfer S.H., Cohen J. Severe traumatic brain injury. Resuscitation. 48:2001;77-90.
2. Clausen T., Bullock R. Medical treatment and neuroprotection in traumatic brain injury. Curr. Pharm. Des. 7:2001;1517-1532.
3. Faden A.I. Neuroprotection and traumatic brain injury. Arch. Neurol. 58:2001;1553-1555.
4. Ronne-Engstrom E., Hillered L., Flink R., Spannare B., Ungerstedt U., Carlson H. Intracerebral microdialysis of extracellular amino acids in the human epileptic focus. J. Cereb. Blood Flow Metab. 12:1992;873-876.
5. Persson L., Valtysson J., Enblad P., Warme P.-E., Cesarini K., Lewen A.et al. Neurochemical monitoring using intracerebral microdialysis in patients with subarachnoid haemorrhage. J. Neurosurg. 84:1996;606-616.
6. Bullock R., Zauner A., Woodward J.J., Myseros J., Choi S.C., Ward J.D.et al. Factors affecting excitatory amino acid release following severe human head injury. J. Neurosurg. 89:1998;507-518.
7. Vespa P., Prins M., Ronne-Engstrom E., Caron M., Shalmon E., Hovda D.A.et al. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. J. Neurosurg. 89:1998;971-982.
8. Choi DW. Excitotoxicity. In: Meldrum BS, editor. Excitatory amino acid antagonists. Oxford: Blackwell; 1991. p. 216-36.
9. Katayama Y., Becker D.P., Tamura T., Hovda D.A. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73:1990;889-900.
10. Nilsson P., Hillered L., Ponten U., Ungerstedt U. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J. Cereb. Blood Flow Metab. 10:1990;631-637.
11. Adelson P.D., Kochanek P.M. Head injury in children. J. Child Neurol. 13:1998;2-15.
12. Feickert H.J., Drommer S., Heyer R. Severe head injury in children: impact of risk factors on outcome. J. Trauma. 47:1999;33-38.
13. Rauen T., Wiessner M. Fine tuning of glutamate uptake and degradation in glial cells: common transcriptional regulation of GLAST1 and GS. Neurochem. Int. 37:2000;179-189.
14. Daikhin Y., Yudkoff M. Compartmentation of brain glutamate metabolism in neurons and glia. J. Nutrition. 130:2000;1026S-1031S.
15. Globus M.Y.T., Ginsberg M.D., Busto R. Excitotoxic index - a biochemical marker of selective vulnerability. Neurosci. Lett. 127:1991;39-42.
16. Teasdale G., Jennett B. Assessment of coma and impaired consciousness. Lancet. ii:1974;81-84.
17. Wilson J.T., Pettigrew L.E., Teasdale G.M. Structured interviews for the Glasgow Outcome Scale and the Extended Glasgow Outcome Scale: guidelines for their use. J. Neurotrauma. 15:1998;573-585.
18. Tolias C.M., Richards D.A., Bowery N.G., Sgouros S. Extracellular glutamate in the brain of children with severe head injury. A pilot microdialysis study. Childs Nerv. Syst. 18:2002;368-374.
19. Bezzi P., Carmignoto G., Pasti L., Vesce S., Rossi D., Rizzini B.L.et al. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391:1998;281-285.
20. Bernath S. Calcium-independent release of amino acid neurotransmitters: fact or artifact? Prog Neurobiol 38:57-91.
21. Westerink B.H.C., Timmerman W. Do neurotransmitters sampled by brain microdialysis reflect functional release? Anal. Chim. Acta. 379:1999;263-274.
22. Richards D.A., Morrone L.A., Bagetta G., Bowery N.G. Effects of α-dendrotoxin and dendrotoxin K on extracellular excitatory amino acids and on electroencephalograph spectral power in the hippocampus of anaesthetised rats. Neurosci. Lett. 293:2000;183-186.
23. Benveniste H., Huttemeier P.C. Microdialysis - theory and application. Prog. Neurobiol. 35:1990;195-215.
24. Hillered L., Persson L. Neurochemical monitoring of the acutely injured human brain. Scand. J. Clin. Lab. Invest. 59:1999;9-18.
25. Obrenovitch T.P., Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J. Neurotrauma. 14:1997;677-698.
26. Obrenovitch T.P., Urenjak J., Zilkha E., Jay T.M. Excitotoxicity in neurological disorders - the glutamate paradox. Int. J. Dev. Neurosci. 18:2000;281-287.
27. Barbour B., Hausser M. Intersynaptic diffusion of neurotransmitter. Trends Neurosci. 20:1997;377-384.
28. Zoli M., Torri C., Ferrari R., Jansson A., Zini I., Fuxe K.et al. The emergence of the volume transmission concept. Brain Res. Rev. 26:1998;136-147.
29. Vargova L., Jendelova P., Chvatal A., Sykova E. Glutamate, NMDA, and AMPA induced changes in extracellular space volume and tortuosity in the rat spinal cord. J. Cereb. Blood Flow Metab. 21:2001;1077-1089.
30. Dolinska M., Dybel A., Hilgier W., Zielinska M., Zablocka B., Buzanska L.et al. Glutamine transport in C6 glioma cells: substrate specificity and modulation in a glutamine deprived culture medium. J. Neurosci. Res. 66:2001;959-966.
31. Newcomb R., Sun X., Taylor L., Curthoys N., Giffard R.G. Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death. J. Biol. Chem. 272:1997;11276-11282.
32. Newcomb R., Pierce A.R., Kano T., Meng W., Bosque-Hamilton P., Taylor L.et al. Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Res. 813:1998;103-111.
33. Mena F.V., Baab P.J., Zielke C.L., Zielke H.R. In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain. J. Neurosci. Res. 60:2000;632-641.
34. Murthy S.N., Janardanasarma M.K. Identification of L-amino acid/L-lysine alpha-amino oxidase in mouse brain. Mol. Cell. Neurosci. 197:1999;13-23.