Mechanisms responsible for catalysis of the inhibition of factor Xa or thrombin by antithrombin using a covalent antithrombin-heparin complex

Journal of Biological Chemistry

Volumn 278, Issue 26, 2003, Pages 23398-23409

  Paredes, Nethnapha ^a,b   Wang, Aimin ^c   Berry, Leslie R ^a,b   Smith, Lesley J ^a   Stafford, Alan R ^a   Weitz, Jeffrey I ^a   Chan, Anthony K C ^a,b,d  

^a HENDERSON RESEARCH CENTRE   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c LERNER RESEARCH INSTITUTE   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHROMATOGRAPHIC ANALYSIS; COMPLEXATION;

POTENT ABILITY;

BLOOD;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; HEPARIN; MONOSACCHARIDE; SEPHAROSE; THROMBIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CHROMATOGRAPHY; COMPLEX FORMATION; COVALENT BOND; DISSOCIATION; FLUORESCENCE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ANTITHROMBIN III; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, AGAROSE; CHROMATOGRAPHY, GEL; FACTOR XA; HEPARIN; HUMANS; MOLECULAR WEIGHT; PROTEIN BINDING; THROMBIN;

EID: 0037931367     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302895200     Document Type: Article

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