The influence of arm length asymmetry and base substitution on the activity of the 10-23 DNA enzyme

Antisense and Nucleic Acid Drug Development

Volumn 10, Issue 5, 2000, Pages 323-332

  Cairns, M J ^a   Hopkins, T M ^a   Witherington, C ^a   Sun, L Q ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYRIBONUCLEOTIDE; RIBOZYME;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RAT; RNA CLEAVAGE;

ANIMALIA;

EID: 0033761964     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.2000.10.323     Document Type: Article

References (23)

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21. A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: Advantages of an asymmetric design
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23. The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis