Mutations in precore and core promoter region of HBV in patients with hepatic failure

Hepatobiliary and Pancreatic Diseases International

Volumn 1, Issue 1, 2002, Pages 63-67

  Li, Lan Juan ^a   Ruan, Bing ^a   Dennin, Reinhard H ^b   Wo, Jian Er ^a   Chen, Zhi ^a   Chen, Ya Gang ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Luebeck Medical College   (Germany)

Author keywords

Gene; Hepatitis B virus; Mutations

Indexed keywords

ADENOSINE; GUANINE; HEPATITIS B(E) ANTIGEN; THYMINE; VIRUS DNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; HEPATITIS B VIRUS; HUMAN; LIVER CIRRHOSIS; LIVER FAILURE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; VIRUS ISOLATION;

BASE SEQUENCE; HEPATITIS B CORE ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER FAILURE; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROMOTER REGIONS (GENETICS);

EID: 0037868190     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Lee WM. Hepatitis B virus infection. N Eng J Med 1997; 337: 1733-1745.
2. Petrosillo N, Ippolito G, Solforosi L, et al. Molecular epidemiology of an outbreak of fulminant hepatitis B. J Clin Microbiol 2000; 38: 2975-2981.
3. Lindh M, Hannoun C, Dhillon AP, et al. Core promoter mutation and genotypes in relation to viral replication and liver damage in East Asia hepatitis B virus carriers. J Infect Dis 1999; 179: 775-782.
4. Takahashi K, Ohta Y, Kanai Y, et al. Clinical implications of mutations C-to-T1653 and T-to-C/A/G1753 of hepatitis B virus genotype C genome in chronic liver disease. Arch Virol 1999; 144: 1299-1308.
5. Chen HLY, Hussain M, Lok ASF. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology 1999; 29: 976-984.
6. Lindh M, Furuta Y, Vahlne A, et al. Emergence of precore TAG mutation during hepatitis B e seroconversion and its dependence on pregenomic base pairing between nucleotides 1858 of 1896. J Infect Dis 1995; 172: 1343-1347.
7. Okamoto H, Tsuda F, Sakugawa H, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 1988; 69: 2575-2583.
8. Mizokami M, Nakano T, Orito E, et al. Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns. FEBS Lett 1999; 450: 66-71.
9. Scaglioni PP, Melegari M, Wands JR. Biological properties of hepatitis B viral genomes with mutations in the precore promoter and precore, open reading frame. Virology 1997; 233: 374-381.
10. Buckwold VE, Xu Z, Chen M, et al. Effects of a naturally occurring mutation in the hepatitis virus basal core promoter on precore gene expression and viral replication. J Virol 1996; 70: 5845-5851.
11. Gunther S, Piwooom N, Will H. Wild type levels of pregenomic RNA and replication but reduced pre - C RNA and e-antigen synthesis of hepatitis B virus with C(1653)-T, A(1762)-T, and G(1764)-A mutations in the core promoter. J Gen Virol 1998; 79: 375-380.
12. Hu GM, Lee YI, Dong JS, et al. Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis: implications of clustering changes in a small region of the HBV core region. J Med Virol 1996; 48: 38-46.
13. Buckwold VE, Xu Z, Yen B, et al. Effects of a frequent double-nucleotide basal core promoter mutations on hepatitis B virus gene expression and replication. J Gen Virol 1997; 78: 2055-2065.
14. Stemler M, Weimer T, Tu Z-X, et al. Mapping of B-cell epitopes of the hepatitis B virus X protein. J Virol 1990; 64: 2802-2809.