메뉴 건너뛰기




Volumn 11, Issue 3-4, 2003, Pages 335-344

The immune decision toward allograft tolerance in non-human primates requires early inhibition of innate immunity and induction of immune regulation

Author keywords

Deoxyspergualin; Heat shock protein; Innate immunity; NF B; Primate; Tolerance

Indexed keywords

15 DEOXYSPERGUALIN; ACETYLSALICYLIC ACID; GAMMA INTERFERON; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOTOXIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; METHYLPREDNISOLONE; PROTEIN; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG;

EID: 0037850570     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(03)00054-6     Document Type: Article
Times cited : (27)

References (45)
  • 1
    • 0034720783 scopus 로고    scopus 로고
    • Durable donor-specific T and B cell tolerance in rhesus macaques-induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy
    • Thomas JM, Eckhoff DE, Contrereas JL, Lobashevsky AL, Hubbard WJ, Moore JK, et al. Durable donor-specific T and B cell tolerance in rhesus macaques-induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy. Transplantation 2000;69(12):2497-2503.
    • (2000) Transplantation , vol.69 , Issue.12 , pp. 2497-2503
    • Thomas, J.M.1    Eckhoff, D.E.2    Contrereas, J.L.3    Lobashevsky, A.L.4    Hubbard, W.J.5    Moore, J.K.6
  • 2
    • 0035672484 scopus 로고    scopus 로고
    • STEALTH matters: A novel paradigm of durable primate allograft tolerance
    • Thomas JM, Hubbard WJ, Sooudi SK, Thomas FT. STEALTH matters: A novel paradigm of durable primate allograft tolerance. Immunol Rev 2001;183:223-233.
    • (2001) Immunol Rev , vol.183 , pp. 223-233
    • Thomas, J.M.1    Hubbard, W.J.2    Sooudi, S.K.3    Thomas, F.T.4
  • 4
    • 0001722505 scopus 로고    scopus 로고
    • RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    • Wu L, D'Amico A, Winkel KD, Suter M, Lo D, Shortman K. RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 1998;9(6):839-847.
    • (1998) Immunity , vol.9 , Issue.6 , pp. 839-847
    • Wu, L.1    D'Amico, A.2    Winkel, K.D.3    Suter, M.4    Lo, D.5    Shortman, K.6
  • 5
    • 0032525243 scopus 로고    scopus 로고
    • Peritransplant tolerance induction with anti-CD3-immunotoxin: A matter of proinflammatory cytokine control
    • Contreras JL, Wang PX, Eckhoff DE, Lobashevsky AL, Asiedu C, Frenette L, et al. Peritransplant tolerance induction with anti-CD3-immunotoxin: A matter of proinflammatory cytokine control. Transplantation 1998;65(9):1159-1169.
    • (1998) Transplantation , vol.65 , Issue.9 , pp. 1159-1169
    • Contreras, J.L.1    Wang, P.X.2    Eckhoff, D.E.3    Lobashevsky, A.L.4    Asiedu, C.5    Frenette, L.6
  • 6
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999;18(49):6853-6866.
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6853-6866
    • Pahl, H.L.1
  • 7
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
    • Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 2000;12(11):1539-1546.
    • (2000) Int Immunol , vol.12 , Issue.11 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 8
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci S, Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 2001;13(1):114-119.
    • (2001) Curr Opin Immunol , vol.13 , Issue.1 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 12
    • 0034898199 scopus 로고    scopus 로고
    • Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: Differences from hydrocortisone-treated dendritic cells
    • Bellinghausen I, Brand U, Steinbrink K, Enk AH, Knop J, Saloga J. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: Differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol 2001;108(2):242-249.
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.2 , pp. 242-249
    • Bellinghausen, I.1    Brand, U.2    Steinbrink, K.3    Enk, A.H.4    Knop, J.5    Saloga, J.6
  • 14
    • 0032824438 scopus 로고    scopus 로고
    • Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification
    • Lobashevsky A, Smith JP, Kasten-Jolly J, Horton H, Knapp L, Bontrop RE, et al. Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification. Tissue Antigens 1999;54(3):254-263.
    • (1999) Tissue Antigens , vol.54 , Issue.3 , pp. 254-263
    • Lobashevsky, A.1    Smith, J.P.2    Kasten-Jolly, J.3    Horton, H.4    Knapp, L.5    Bontrop, R.E.6
  • 15
    • 0033695173 scopus 로고    scopus 로고
    • Six mamu-A locus alleles defined by a polymerase chain reaction sequence-specific primer method
    • Lobashevsky AL, Thomas JM. Six mamu-A locus alleles defined by a polymerase chain reaction sequence-specific primer method. Hum Immunol 2000;61(10):1013-1020.
    • (2000) Hum Immunol , vol.61 , Issue.10 , pp. 1013-1020
    • Lobashevsky, A.L.1    Thomas, J.M.2
  • 16
    • 0018758940 scopus 로고
    • Effect of rabbit anti-human thymocyte globulin on lymphocyte sub-populations and functions following allotransplantation in the rhesus monkey
    • Thomas JM, Carver M, Scott J, Williams E, Thomas F. Effect of rabbit anti-human thymocyte globulin on lymphocyte sub-populations and functions following allotransplantation in the rhesus monkey. Transplantation 1979;27(3):163-170.
    • (1979) Transplantation , vol.27 , Issue.3 , pp. 163-170
    • Thomas, J.M.1    Carver, M.2    Scott, J.3    Williams, E.4    Thomas, F.5
  • 17
    • 0023097262 scopus 로고
    • Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. I. In vivo parameters and immunohistologic evidence suggesting microchimerism
    • Thomas JM, Carver M, Cunningham P, Park K, Gonder J, Thomas F. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. I. In vivo parameters and immunohistologic evidence suggesting microchimerism. Transplantation 1987;43(3):332-338.
    • (1987) Transplantation , vol.43 , Issue.3 , pp. 332-338
    • Thomas, J.M.1    Carver, M.2    Cunningham, P.3    Park, K.4    Gonder, J.5    Thomas, F.6
  • 18
    • 0030871990 scopus 로고    scopus 로고
    • Preclinical studies of allograft tolerance in rhesus monkeys: A novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts
    • Thomas JM, Neville DM. Contreras JL, Eckhoff DE, Meng G, Lobashevsky AL, et al. Preclinical studies of allograft tolerance in rhesus monkeys: A novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts. Transplantation 1997;64(1):124-135.
    • (1997) Transplantation , vol.64 , Issue.1 , pp. 124-165
    • Thomas, J.M.1    Neville, D.M.2    Contreras, J.L.3    Eckhoff, D.E.4    Meng, G.5    Lobashevsky, A.L.6
  • 19
    • 0034992683 scopus 로고    scopus 로고
    • Successful reversal of streptozotocin-induced diabetes with stable allogeneic islet function in a preclinical model of type 1 diabetes
    • Thomas JM, Contreras JL, Smyth CA, Lobashevsky A, Jenkins S, Hubbard WJ, et al. Successful reversal of streptozotocin-induced diabetes with stable allogeneic islet function in a preclinical model of type 1 diabetes. Diabetes 2001;50(6):1227-1236.
    • (2001) Diabetes , vol.50 , Issue.6 , pp. 1227-1236
    • Thomas, J.M.1    Contreras, J.L.2    Smyth, C.A.3    Lobashevsky, A.4    Jenkins, S.5    Hubbard, W.J.6
  • 20
    • 0027260855 scopus 로고
    • Synthesis and background chemistry of 15-deoxyspergualin
    • Maeda K, Umeda Y, Saino T. Synthesis and background chemistry of 15-deoxyspergualin. Ann NY Acad Sci 1993;685:123-135.
    • (1993) Ann NY Acad Sci , vol.685 , pp. 123-135
    • Maeda, K.1    Umeda, Y.2    Saino, T.3
  • 21
    • 0036394295 scopus 로고    scopus 로고
    • Converting non-human primate dendritic cells into potent antigen-specific cellular immunosuppressants by genetic modification
    • Asiedu C, Pereboev A, Curiel DT, Dong SS, Hutchings A, Thomas JM. Converting non-human primate dendritic cells into potent antigen-specific cellular immunosuppressants by genetic modification. Immunol Res 2002;26(1-3):297-302.
    • (2002) Immunol Res , vol.26 , Issue.1-3 , pp. 297-302
    • Asiedu, C.1    Pereboev, A.2    Curiel, D.T.3    Dong, S.S.4    Hutchings, A.5    Thomas, J.M.6
  • 22
    • 0034908234 scopus 로고    scopus 로고
    • A tripartite anoikis-like mechanism causes early isolated islet apoptosis
    • Thomas F, Wu J, Contreras JL, Smyth C, Bilbao G, He J, et al. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 2001;130(2):333-338.
    • (2001) Surgery , vol.130 , Issue.2 , pp. 333-338
    • Thomas, F.1    Wu, J.2    Contreras, J.L.3    Smyth, C.4    Bilbao, G.5    He, J.6
  • 23
    • 0033572898 scopus 로고    scopus 로고
    • Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin
    • Thomas JM, Contreras JL, Jiang XL, Eckhoff DE, Wang PX, Hubbard WJ, et al. Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin. Transplantation 1999;68(11):1660-1673.
    • (1999) Transplantation , vol.68 , Issue.11 , pp. 1660-1673
    • Thomas, J.M.1    Contreras, J.L.2    Jiang, X.L.3    Eckhoff, D.E.4    Wang, P.X.5    Hubbard, W.J.6
  • 24
    • 0141551268 scopus 로고    scopus 로고
    • Does a type 2-biased relative cytokine ratio (RCR) during recovery from T cell depletion forecast permanent tolerance in primates?
    • Thomas JM, Jenkins S, Contreras J, Eckhoff D, Hubbard WJ, Thomas FT, et al. Does a type 2-biased relative cytokine ratio (RCR) during recovery from T cell depletion forecast permanent tolerance in primates? Am J Transplant 2002;2(Suppl. 3):144.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 144
    • Thomas, J.M.1    Jenkins, S.2    Contreras, J.3    Eckhoff, D.4    Hubbard, W.J.5    Thomas, F.T.6
  • 25
    • 0035036979 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques
    • Hubbard WJ, Moore JK, Contreras JL, Smyth CA, Chen ZW, Lobashevsky AL, et al. Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques. Hum Immunol 2001;62(5):479-487.
    • (2001) Hum Immunol , vol.62 , Issue.5 , pp. 479-487
    • Hubbard, W.J.1    Moore, J.K.2    Contreras, J.L.3    Smyth, C.A.4    Chen, Z.W.5    Lobashevsky, A.L.6
  • 26
    • 0028895152 scopus 로고
    • Elucidating the mechanism of action of the immunosuppressant 15-deoxyspergualin
    • Nadler SG, Eversole AC, Tepper MA, Cleaveland JS. Elucidating the mechanism of action of the immunosuppressant 15-deoxyspergualin. Ther Drug Monit 1995;17(6):700-703.
    • (1995) Ther Drug Monit , vol.17 , Issue.6 , pp. 700-703
    • Nadler, S.G.1    Eversole, A.C.2    Tepper, M.A.3    Cleaveland, J.S.4
  • 29
    • 0032031409 scopus 로고    scopus 로고
    • IFN-gamma is critical for long-term allograft survival-induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
    • Konieczny BT, Dai Z, Elwood ET, Saleem S, Linsley PS, Baddoura FK, et al. IFN-gamma is critical for long-term allograft survival-induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998;160(5):2059-2064.
    • (1998) J Immunol , vol.160 , Issue.5 , pp. 2059-2064
    • Konieczny, B.T.1    Dai, Z.2    Elwood, E.T.3    Saleem, S.4    Linsley, P.S.5    Baddoura, F.K.6
  • 30
    • 0033917737 scopus 로고    scopus 로고
    • The role of CD154-CD40 vs. CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
    • Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, et al. The role of CD154-CD40 vs. CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 2000;106(1):63-72.
    • (2000) J Clin Invest , vol.106 , Issue.1 , pp. 63-72
    • Kishimoto, K.1    Dong, V.M.2    Issazadeh, S.3    Fedoseyeva, E.V.4    Waaga, A.M.5    Yamada, A.6
  • 32
    • 0035062434 scopus 로고    scopus 로고
    • Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo
    • Waaga AM, Gasser M, Kist-Van Holthe JE, Najafian N, Muller A, Vella JP, et al. Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest 2001;107(7):909-916.
    • (2001) J Clin Invest , vol.107 , Issue.7 , pp. 909-916
    • Waaga, A.M.1    Gasser, M.2    Kist-Van Holthe, J.E.3    Najafian, N.4    Muller, A.5    Vella, J.P.6
  • 33
    • 0035869432 scopus 로고    scopus 로고
    • IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    • Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001;166(6):3789-3796.
    • (2001) J Immunol , vol.166 , Issue.6 , pp. 3789-3796
    • Hara, M.1    Kingsley, C.I.2    Niimi, M.3    Read, S.4    Turvey, S.E.5    Bushell, A.R.6
  • 34
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: New therapeutics for graft-vs.-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(+)CD25(+) immunoregulatory T cells: New therapeutics for graft-vs.-host disease. J Exp Med 2002;196(3):401-406.
    • (2002) J Exp Med , vol.196 , Issue.3 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 35
    • 0036604283 scopus 로고    scopus 로고
    • Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
    • Graca L, Thompson S, Lin CY, Adams E, Cobbold SP, Waldmann H. Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. J Immunol 2002;168(11):5558-5565.
    • (2002) J Immunol , vol.168 , Issue.11 , pp. 5558-5565
    • Graca, L.1    Thompson, S.2    Lin, C.Y.3    Adams, E.4    Cobbold, S.P.5    Waldmann, H.6
  • 36
    • 0028158319 scopus 로고
    • High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
    • Bacchetta R, Bigler M, Touraine JL, Parkman R, Tovo PA, Abrams J, et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994;179(2):493-502.
    • (1994) J Exp Med , vol.179 , Issue.2 , pp. 493-502
    • Bacchetta, R.1    Bigler, M.2    Touraine, J.L.3    Parkman, R.4    Tovo, P.A.5    Abrams, J.6
  • 37
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, De Vries JE, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389(6652):737-742.
    • (1997) Nature , vol.389 , Issue.6652 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    De Vries, J.E.6
  • 38
    • 0028596433 scopus 로고
    • The potential impact of the reperfusion injury on acute and chronic rejection events following organ transplantation
    • Land W. The potential impact of the reperfusion injury on acute and chronic rejection events following organ transplantation. Transplant Proc 1994;26(6):3169-3171.
    • (1994) Transplant Proc , vol.26 , Issue.6 , pp. 3169-3171
    • Land, W.1
  • 39
    • 0027979555 scopus 로고
    • The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants
    • Land W, Schneeberger H, Schleibner S, Illner WD, Abendroth D, Rutili G, et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994;57(2):211-217.
    • (1994) Transplantation , vol.57 , Issue.2 , pp. 211-217
    • Land, W.1    Schneeberger, H.2    Schleibner, S.3    Illner, W.D.4    Abendroth, D.5    Rutili, G.6
  • 40
    • 0037096712 scopus 로고    scopus 로고
    • Apoptosis and inflammation in renal reperfusion injury
    • Daemen MA, De Vries B, Buurman WA. Apoptosis and inflammation in renal reperfusion injury. Transplantation 2002;73(11):1693-1700.
    • (2002) Transplantation , vol.73 , Issue.11 , pp. 1693-1700
    • Daemen, M.A.1    De Vries, B.2    Buurman, W.A.3
  • 41
    • 0036184501 scopus 로고    scopus 로고
    • Postischemic reperfusion injury to allografts - A case for 'innate immunity'?
    • Land W. Postischemic reperfusion injury to allografts - A case for 'innate immunity'? Eur Surg Res 2002;34(1-2):160-169.
    • (2002) Eur Surg Res , vol.34 , Issue.1-2 , pp. 160-169
    • Land, W.1
  • 42
    • 0037108993 scopus 로고    scopus 로고
    • Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury
    • Hoffmann SC, Kampen RL, Amur S, Sharaf MA, Kleiner DE, Hunter K, et al. Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury. Transplantation 2002;74(7):916-923.
    • (2002) Transplantation , vol.74 , Issue.7 , pp. 916-923
    • Hoffmann, S.C.1    Kampen, R.L.2    Amur, S.3    Sharaf, M.A.4    Kleiner, D.E.5    Hunter, K.6
  • 43
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
    • Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, et al. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000;6(4):435-442.
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 435-442
    • Asea, A.1    Kraeft, S.K.2    Kurt-Jones, E.A.3    Stevenson, M.A.4    Chen, L.B.5    Finberg, R.W.6
  • 44
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Galluci S, Lolkema M, Matzinger P. Natural adjuvants: Endogenous activators of dendritic cells. Nat Med 1999;5(11):1249-1255.
    • (1999) Nat Med , vol.5 , Issue.11 , pp. 1249-1255
    • Galluci, S.1    Lolkema, M.2    Matzinger, P.3
  • 45
    • 0028201732 scopus 로고
    • Tolerance, danger and the extended family
    • Matzinger P. Tolerance, danger and the extended family. Annu Rev Immunol 1994;12:991-1045.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.