Pharmacotherapy of painful diabetic neuropathy

Current Pain and Headache Reports

Volumn 7, Issue 3, 2003, Pages 169-177

  Barbano, Richard ^a   Hart Gouleau, Stephanie ^a   Pennella Vaughan, Janet ^a   Dworkin, Robert H ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; AMITRIPTYLINE; ANTICONVULSIVE AGENT; BENZATROPINE; CAPSAICIN; CARBAMAZEPINE; CODEINE; DESIPRAMINE; DIAZEPAM; FIDARESTAT; FLUOXETINE; GABAPENTIN; IMIPRAMINE; LAMOTRIGINE; LIDOCAINE; MAPROTILINE; MEXILETINE; MORPHINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NORTRIPTYLINE; OPIATE; OXYCODONE; PAROXETINE; PHENYTOIN; SEROTONIN UPTAKE INHIBITOR; TOPICAL AGENT; TOPIRAMATE; TRAMADOL; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

ACUPUNCTURE; ALTERNATIVE MEDICINE; ANALGESIC ACTIVITY; ANTICHOLINERGIC EFFECT; ANTINOCICEPTION; ASTHENIA; ATAXIA; BODY WEIGHT DISORDER; BURNING SENSATION; CLINICAL TRIAL; COGNITIVE DEFECT; CONFUSION; CONSTIPATION; DIABETES MELLITUS; DIABETIC NEUROPATHY; DIARRHEA; DIPLOPIA; DIZZINESS; DRUG EFFICACY; DRUG RESEARCH; DRUG TOLERABILITY; ERYTHEMA; GASTROINTESTINAL SYMPTOM; GINGIVA HYPERPLASIA; HEADACHE; HUMAN; HYPERGLYCEMIA; MAGNETISM; MORBIDITY; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; ORTHOSTATIC HYPOTENSION; PATHOPHYSIOLOGY; PHYSICIAN; REVIEW; SOMNOLENCE; SYMPTOMATOLOGY; TACHYCARDIA; URINARY HESITANCY; URINE RETENTION; VERTIGO; VISUAL IMPAIRMENT; WEIGHT REDUCTION; XEROSTOMIA; PAIN;

DIABETIC NEUROPATHIES; HUMANS; PAIN;

EID: 0037829772     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-003-0070-9     Document Type: Review

References (81)

1. Pirart J: Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973: Part 1. Diabetes Care 1978, 1:168-178.
2. Pirart J: Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973: Part 2. Diabetes Care 1978, 1:252-261.
3. Dyck PJ, Kratz KM, Karnes JL, et al.: The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 1993, 43:817-824.
4. Tesfaye S, Stevens LK, Stephenson JM, et al.: Prevalence of diabetic peripheral neuropathy and its relation to glycemic control and potential risks factors: the EURODIAB IDDM Complications Study. Diabetologia 1996, 39:1377-1384.
5. Maser RE, Steenkiste AR, Dorman JS, et al.: Epidemiological correlates of diabetic neuropathy: report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989, 38:1456-1461.
6. Vinik AI: Diabetic neuropathy: pathogenesis and therapy. Am J Med 1999, 107(suppl 2):17-26.
7. Sima A: Metabolic alterations of peripheral nerve in diabetes. Semin Neurol 1996, 16:129-137.
8. Greene DA, Stevens MJ, Feldman EL: Diabetic neuropathy: scope of the syndrome. Am J Med 1999, 107(suppl 2):2-8.
9. Younger DS, Bronfin L: Overview of diabetic neuropathy. Semin Neurol 1996, 16:107-113.
10. Dejgaard A: Pathophysiology and treatment of diabetic neuropathy. Diabet Med 1998, 15:97-112.
11. Dyck PJ: Detection, characterization, and staging of polyneuropathy: assessed in diabetes. Muscle Nerve 1988, 11:21-32.
12. Diabetes Control and Complications Trial Research Group: The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med 1995, 122:561-568.
13. Perkins BA, Olaleye D, Zinman B, Bril V: Simple screening tests for peripheral neuropathy in the diabetes clinic. Diabetes Care 2001, 24:250-256.
14. Galer BS, Gianas A, Jensen MP: Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 2000, 47:123-128.
15. Herrmann DN, Fregusson ML, Logigian EL: Conduction slowing in diabetic distal polyneuropathy. Muscle Nerve 2002, 232-237.
16. Max MB, Culnane M, Schafer SC, et al.: Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987, 37:589-596.
17. Max MB, Lynch SA, Muir J, et al.: Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992, 326:1250-1256.
18. Max MB, Ranganna KK, Schafer SC, et al.: Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. Pain 1991, 45:3-9.
19. Vrethem M, Boivie J, Arnqvist H, et al.: A comparison of amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics. Clin J Pain 1997, 14:313-323.
20. Turkington RW: Depression masquerading as diabetic neuropathy. JAMA 1980, 243:1147-1150.
21. Kvinesdal B, Molin J, Froland A, Gram LF: Imipramine treatment of painful diabetic neuropathy. JAMA 1984, 251:1727-1730.
22. Gomez-Perez FJ, Rull JA, Dies H, et al.: Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy: a double-blind cross-over study. Pain 1985, 23:395-400.
23. Gomez-Perez FJ, Choza R, Rios JM, et al.: Nortriptyline-fluphenazine vs carbamazepine in the symptomatic treatment of diabetic neuropathy. Arch Med Res 1996, 27:525-529.
24. Sindrup SH, Ejlertsen B, Froland A, et al.: Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function. Eur J Clin Pharmacol 1989, 37:151-153.
25. Sindrup SH, Gram LF, Skjold T, et al.: Concentration-response relationship in imipramine treatment of diabetic neuropathy symptoms. Clin Pharmacol Ther 1990, 47:509-515.
26. Sindrup SH, Gram LF, Brosen K, et al.: The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990, 42:135-144.
27. Semenchuk MR, Sherman S, Davis B: Double-blind, randomized trial of buproprion SR for the treatment of neuropathic pain. Neurology 2001, 57:1583-1588.
28. Davis JL, Smith RL: Painful peripheral diabetic neuropathy treated with venlafaxine HCl extended release capsules. Diabetes Care 1999, 22:1909-1910.
29. Lithner F: Venlafaxine in treatment of severe painful peripheral diabetic neuropathy. Diabetes Care 2000, 23:1710-1711.
30. Rull JA, Quibrera R, Gonzales-Millan H, Lozano Castaneda O: Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): double-blind cross-over trial. Diabetologia 1969, 5:215-218.
31. Saudek CD, Werns S, Reidenberg MM: Phenytoin in the treatment of diabetic symmetrical polyneuropathy. Clin Pharmacol Ther 1977, 22:196-199.
32. Chadda VS, Mathur MS: Double-blind study of the effects of diphenylhydantoin sodium on diabetic neuropathy. J Assoc Physicians India 1978, 26:403-406.
33. Gorson KC, Schott C, Rand WM, et al.: Gabapentin in the treatment of painful diabetic neuropathy: a placebo-controlled, double-blind, crossover trial. Neurology 1998, 50(suppl 4):A103.
34. Backonja M, Beydoun A, Edwards KR, et al.: Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998, 280:1831-1836.
35. Morello CM, Leckband SG, Stoner CP, et al.: Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic neuropathy pain. Arch Intern Med 1999, 159:1931-1937.
36. Eisenberg E, Alon N, Ishay A, et al.: Lamotrigine in the treatment of painful diabetic neuropathy. Eur J Neurol 1998, 5:167-173.
37. Eisenberg E, Lurie Y, Braker C, et al.: Lamotrigine reduces painful diabetic neuropathy: a randomized, controlled study. Neurology 2001, 57:505-509.
38. McCleane G: 200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomized, double-blind, placebo-controlled trial. Pain 1999, 83:105-107.
39. Edwards KR, Glantz MJ, Button J, et al.: Efficacy and safety of topiramate in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study (Poster presentation). Neurology 2000, 5(suppl 3):A81.
40. Lopez-Trigo J, Serra J, Ortiz P, Sancho J: Topiramate versus amitriptyline on diabetic neuropathic pain. Poster presented at the XVII World Congress of Neurology. Barcelona: June 17-22, 2001.
41. Max MB, Schafer SC, Culnane M, et al.: Association of pain relief with drug side-effects in postherpetic neuralgia: a single dose study of clonidine, codeine, ibuprofen, and placebo. Clin Pharmacol Ther 1998, 43:363-371.
42. Watson CP, Babul N: Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology 1998, 50:1837-1841.
43. Rowbotham MC, Reisner-Keller LA, Fields HL: Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 1991, 41:1024-1028.
44. Raja SN, Haythornwaite JA, Pappagallo M, et al.: Opioids versus antidepressants in postherpetic neuralgia. Neurology 2002, 59:1015-1021.
45. Harati Y, Gooch C, Swenson M, et al.: Double-blind randomized trial of tramadol for the treatment of pain of diabetic neuropathy. Neurology 1998, 50:1842-1846.
46. Sindrup SH, Andersen G, Madsen C, et al.: Tramadol relieves pain and allodynia in polyneuropathy: a randomized, double-blind, controlled trial. Pain 1999, 83:85-90.
47. Harati Y, Gooch C, Swenson M, et al.: Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy. J Diabetes Complications 2000, 14:65-70.
48. Kastrup J, Petersen P, Dejgard A, et al.: Intravenous lidocaine infusion: a new treatment of chronic painful diabetic neuropathy? Pain 1987, 28:69-75.
49. Dejgaard A, Petersen P, Kastrup J: Mexiletine for treatment of chronic painful diabetic neuropathy. Lancet 1988, 1:9-11.
50. Stracke H, Meyer UE, Schumacher HE, Federlin K: Mexilitine in the treatment of diabetic neuropathy. Diabetes Care 1992, 15:1550-1555.
51. Stracke H, Meyer UE, Schumacher HE: Mexilitine in treatment of painful diabetic neuropathy. Med Klin 1994, 89:124-131.
52. Oskarsson P, Ljunggren JG, Lins E: Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy: the Mexiletine Study Group. Diabetes Care 1997, 20:1594-1597.
53. Devers A, Galer B: Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study. Clin J Pain 2000, 16:205-208.
54. Hart-Gouleau S, Gammaitoni A, Galer B, et al.: Open-label study of the effectiveness and safety of Lidocaine patch 5% (Lidoderm) in patients with painful diabetic neuropathy. Poster presented at the Tenth World Congress on Pain; San Diego. August 2002.
55. Wright JM, Oki JC, Graves L III: Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy. Ann Pharmacother 1997, 31:116-117.
56. Ross DR, Varipapa RJ: Treatment of painful diabetic neuropathy with topical capsaicin. N Engl J Med 1989, 321:474-475.
57. Capsaicin Study Group: Treatment of painful diabetic neuropathy with topical capsaicin: a multicenter, double-blind, vehicle-controlled study. Arch Int Med 1991, 151:2225-2229.
58. Capsaicin Study Group: Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care 1992, 15:159-165.
59. Biesbroeck R, Bril V, Hollander P, et al.: A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv Ther 1995, 12:111-120.
60. Low PA, Opfer-Gehrking TL, Dyck PJ, et al.: Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain 1995, 62:163-168.
61. Caffee HH: Treatment of diabetic neuropathy by decompression of the posterior tibial nerve. Plast Reconstr Surg 2000, 106:813-815.
62. Aszmann OC, Kress KM, Dellon AL: Results of decompression of peripheral nerves in diabetics: a prospective, blinded study. Plast Reconstr Surg 2000, 106:816-822.
63. Allen RD, Al-Harbi IS, Morris J, et al.: Diabetic neuropathy after pancreas transplantation: determinants of recovery. Transplantation 1997, 63:830-838.
64. Tyden G: Long-term effects of pancreatic transplantation on secondary complications of diabetes. Curr Opin Organ Transplantation 2001, 6:194-198.
65. Navarro X, Sutherland DER, Kennedy WR: Long-term effects of pancreas transplantation on diabetic neuropathy. Poster presented at AAEM Annual Meeting. Minneapolis: October 1996.
66. Abuaisha BB, Costanzi JB, Boulton AJ: Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: a long-term study. Diabetes Res Clin Pract 1998, 39:115-121.
67. Armstrong DG, Lavery LA, Fleischli JG, Gilham KA: Is electrical stimulation effective in reducing neuropathic pain in patients with diabetes. J Foot Ankle Surg 1997, 36:260-263.
68. Goodnick PJ, Breakstone K, Wen XL, Kumar A: Acupuncture and neuropathy. Am J Psychiatry 2000, 157:1342-1343.
69. Kalinina OV, Alekseeva NV, Burtsev EM: Infrared laser therapy in distal diabetic polyneuropathy. Zh Nevrol Psikhiatr Im S S Korsakova 1998, 98:23-25.
70. Kumar D, Marshall HJ: Diabetic peripheral neuropathy: amelioration of pain with transcutaneous electrostimulation. Diabetes Care 1997, 20:1702-1705.
71. Rice B, Kalker AJ, Schindler JV, Dixon RM: Effect of biofeedback-assisted relaxation training on foot ulcer healing. J Am Podiatr Med Assoc 2001, 91:132-141.
72. Weintraub MI: Are magnets effective for pain control? JAMA 2000, 284:564-566.
73. Kato N, Kuniharu M, Mitsuhiro M, et al.: Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats. Diabetes Res Clin Pract 2000, 50:77-85.
74. Greene DA, Arezzo JC, Brown MB: Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Neurology 1999, 53:580-591.
75. Hotta N, Toyota T, Matsuoka K for the The SNK-860 Diabetic Neuropathy Study Group: Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care 2001, 24:1776-1782.
76. Handelsman DJ, Turtle JR: Clinical trial of an aldose reductase inhibitor in diabetic neuropathy. Diabetes 1981, 30:459-464.
77. Fagius J, Jameson S: Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy: a clinical and neurophysiological study. J Neurol Neurosurg Psychiatry 1981, 44:991-1001.
78. Sorbinil Retinopathy Trial Research Group: The sorbinil retinopathy trial: neuropathy results. Neurology 1993, 43:1141-1149.
79. Ziegler D, Mayer P, Rathmann W, Gries FA: One-year treatment with the aldose reductase inhibitor, ponalrestat, in diabetic neuropathy. Diabetes Res Clin Pract 1991, 14(suppl):63-73.
80. Ziegler D, Hanefeld M, Ruhnau KJ, et al.: Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid: a 3-week multicenter, randomized controlled trial (ALADIN study). Diabetologia 1995, 38:1425-1433.
81. Ziegler D, Hanfeld M, Ruhnau KJ, et al.: Treatment of symptomatic diabetic polyneuropathy with the antioxydant alphalipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III study). Diabetes Care 1999, 22:1296-1301.