Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats

Diabetes Research and Clinical Practice

Volumn 50, Issue 2, 2000, Pages 77-85

  Kato, Noriaki ^a   Mizuno, Kuniharu ^a   Makino, Mitsuhiro ^a   Suzuki, Tsunemasa ^a   Yagihashi, Soroku ^b  

^a SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

Author keywords

Diabetic rats; Fidarestat; Long term aldose reductase inhibition; Peripheral neuropathy

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; FIDARESTAT; FRUCTOSE; INOSITOL; PENTOBARBITAL; POLYOL; SORBITOL; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEMYELINATION; DIABETIC NEUROPATHY; DOSE RESPONSE; ENZYME INHIBITION; LONG TERM CARE; MALE; MOTOR NERVE; MYELIN SHEATH; NERVE CONDUCTION; NERVE FIBER DEGENERATION; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NEUROPATHY; RAT; SENSORY NERVE;

ALDEHYDE REDUCTASE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; ENZYME INHIBITORS; FRUCTOSE; HEMOGLOBIN A, GLYCOSYLATED; IMIDAZOLES; IMIDAZOLIDINES; INOSITOL; MALE; MYELIN SHEATH; NERVE FIBERS; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SORBITOL; SURAL NERVE; TIBIAL NERVE; TIME FACTORS;

EID: 0034308188     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(00)00164-9     Document Type: Article

References (25)

1. Greene D.A., Sima A.A.F., Stevens M.J. et al. Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage. Diabetes Metab. Rev. 9:1993;189-217.
2. Low P.A., Lagerlund T.D., McManis P.G. Nerve blood flow and oxygen delivery in normal, diabetic and ischemic neuropathy. Int. Rev. Neurobiol. 31:1989;355-438.
3. Mayer J.H., Tomlinson D.R. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats. Diabetologia. 25:1983;433-438.
4. Notvest R.R., Inserra J.J. Tolrestat, an aldose reductase inhibitor, prevents nerve dysfunction in conscious diabetic rats. Diabetes. 36:1987;500-504.
5. Mizuno K., Kato N., Makino M., Suzuki T., Shindo M. Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy. J. Diabetes Complications. 13:1999;141-150.
6. Cameron N.E., Leonard M.B., Ross I.S., Whiting P.H. The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat. Diabetologia. 29:1986;168-174.
7. Yagihashi S., Kamijo M., Ido Y., Mirrlees D.J. Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Diabetes. 39:1990;690-696.
8. Mizuno K., Kato N., Matsubara A., Nakano K., Kurono M. Effects of a new aldose reductase inhibitor, (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]- 2-carboxamide (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats. Metabolism. 41:1992;1081-1086.
9. Wiethölter H., Hülser P.J., Linington C., Meier D.H., Wessel K. Electrophysiological follow up of experimental allergic neuritis mediated by a permanent T cell line in rats. J. Neurol. Sci. 83:1988;1-14.
10. Kimura J. Nerve conduction studies and electromyography. Dyck P.J., Thomas P.K., Griffin J.W., Low P.A., Poduslo J.F. Peripheral Neuropathy. third ed. 1993;618-621 Saunders, Philadelphia.
11. Kato N., Makino M., Mizuno K., Suzuki T., Shindo M. Serial changes of sensory nerve conduction velocity and minimal F-wave latency in streptozotocin-induced diabetic rats. Neurosci. Lett. 244:1998;169-172.
12. Dyck P.J., Giannini C., Lais A. Pathologic alterations of nerves. Dyck P.J., Thomas P.K., Griffin J.W., Low P.A., Poduslo J.F. Peripheral Neuropathy. third ed. 1993;528-544 Saunders, Philadelphia.
13. Sima A.A.F., Brown M.B., Prashar A., Chakrabarti S., Laudadio C., Greene D.A. The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy. Diabetologia. 35:1992;560-569.
14. Yagihashi S., Kamijo M., Watanabe K. Reduced myelinated fiber size correlates with loss of axonal neurofilaments in peripheral nerve of chronically streptozotocin diabetic rats. Am. J. Pathol. 136:1990;1365-1373.
15. Medori R., Antilio-Gambetti L., Jenich H., Gambetti P. Change in axon size and slow axonal transport are related in experimental diabetic neuropathy. Neurology. 38:1988;597-601.
16. Sugimura K., Windebank A.J., Natarajan V., Lambert E.H., Schmid H.H., Dyck P.J. Interstitial hyperosmolarity may cause axis cylinder shrinkage in streptozotocin diabetic nerve. J. Neuropathol. Exp. Neurol. 39:1980;710-721.
17. Dyck P.J., Karnes J.L., O'Brien P., Okazaki H., Lais A., Engelstad J. The spatial distribution of fiber loss in diabetic polyneuropathy suggests ischemia. Ann. Neurol. 19:1986;440-449.
18. Sasaki H., Schmelzer J.D., Zollman P.J., Low P.A. Neuropathology and blood flow of nerve, spinal roots and dorsal root ganglia in longstanding diabetic rats. Acta Neuropathol. 93:1997;118-128.
19. Waxman S.G. Determinants of conduction velocity in myelinated nerve fibers. Muscle Nerve. 3:1980;141-150.
20. Sima A.A.F., Prashar A., Zhang W.-X., Chakrabarti S., Greene D.A. Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic bio-breeding rat. J. Clin. Invest. 85:1990;1410-1420.
21. Sima A.A.F., Bril V., Nathaniel V., McEwen T.A.J., Brown M.B., Lattimer S.A., Greene D.A. Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. New Engl. J. Med. 319:1988;548-555.
22. Thurston J.H., McDougal D.B. Jr, Hauhart R.E., Schulz D.W. Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Diabetes. 44:1995;190-195.
23. Beyer-Mears A., Diecke F.P.J., Mistry K., Ellison C., Cruz E. Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. Pharmacology. 55:1997;78-86.
24. McPherson J.D., Shilton B.H., Walton D.J. Role of fructose in glycation and cross-linking of proteins. Biochemistry. 27:1988;1901-1907.
25. Suarez G., Maturana J., Oronsky A.L., Raventos-Suarez C. Fructose-induced fluorescence generation of reductively methylated glycated bovine serum albumin. Biochim. Biophys. Acta. 1075:1991;12-19.