The antinociceptive effect of tramadol-venlafaxine combination on the paw withdrawal threshold in a rat model of neuropathic pain

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 5, 2003, Pages 361-365

  Uyar, Meltem ^a   Onal, A ^a   Uyar, M ^a   Dogru, A ^a   Soykan, N ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Antidepressants; Antinociception; Mechanical hyperalgesia; Neuropathic pain; Rats; Tramadol; Venlafaxine

Indexed keywords

SODIUM CHLORIDE; TRAMADOL; VENLAFAXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MIXTURE; LATENT PERIOD; MALE; NERVE COMPRESSION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; RAT; SCIATIC NERVE; STATISTICAL ANALYSIS; WITHDRAWAL REFLEX;

EID: 0037818479     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.5.769657     Document Type: Article

References (22)

1. Zimmermann, M. Pathobiology of neuropathic pain. Eur J Pharmacol 2001, 429(1-3): 23-37.
2. Galer, B.S. Neuropathic pain of peripheral origin: Advances in pharmacologic treatment. Neurology 1995, 45 (Suppl. 9): S17-25.
3. Barkin, R.L., Fawcett, J. The management challenges of chronic pain: The role of antidepressants. Am J Therapeut 2000, 7: 31-47.
4. Schreiber, S., Backer, M.M., Pick, C.G. The antinociceptive effect of venlafaxine in mice is mediated through opiod and adrenergic mechanisms. Neurosci Lett 1999, 273: 85-8.
5. Carlsson, K.H., Jurna, I. Effects of tramadol on motor and sensory responses of the spinal nociceptive system in the rat. Eur J Pharmacol 1987, 139(1): 1-10.
6. Lang, E., Hord, A.H., Denson, D. Venlafaxine hydrochloride (Effexor™) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. Pain 1996, 68: 151-5.
7. Apaydin, S., Uyar, M., Karabay, N.U. et al. The antinociceptive effect of tramadol on a model of neuropathic pain in rats. Life Sci 2000, 66(17): 1627-37.
8. Tsai, Y.C., Sung, Y.H., Chang, P.J. et al. Tramadol relieves thermal hyperalgesia in rats with chronic constriction injury of the sciatic nerve. Fundam Clin Pharmacol 2000, 14(4): 335-40.
9. Markowitz, J.S., Patrick, K.S. Venlafaxine-tramadol similarities. Med Hypotheses 1998, 51(2): 167-8.
10. Kayser, V., Guilbaud, G. Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats. Pain 1990, 41(3): 353-63.
11. Hopwood, S.E., Owesson, C.A., Callado, L.F. et al. Effects of chronic tramadol on pre and postsynaptic measures of monoamine function. J Psychopharmacol 2001, 15(3): 147-53.
12. Bennett, G.J., Xie, Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33(1): 87-107.
13. Ardid, D., Guilbaud, G. Antinociceptive effects of acute and 'chronic' injections of tricyclic antidepressant drugs in a new model of mononeuropathy in rats. Pain 1992, 49(2): 279-87.
14. Acton, J., McKenna, J.E., Melzack, R. Amitriptyline produces analgesia in the formalin pain test. Exp Neurol 1992, 117(1): 94-6.
15. Takasaki, I., Andoh, T., Nitta, M. et al. Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. Jpn J Pharmacol 2000, 83(4): 319-26.
16. Sierralta, F., Pinardi, G., Mendez, M., Miranda, H.F. Interaction of opioids with antidepressant-induced antinociception. Psychopharmacology (Berl) 1995, 122(4): 374-8.
17. Gatch, M.B., Negus, S.S., Mello, N.K. Antinociceptive effects of monoamine reuptake inhibitors administered alone or in combination with mu opioid agonists in rhesus monkeys. Psychopharmacology (Berl) 1998, 135(1): 99-106.
18. Eisenach, J.C., Gebhart, G.F. Intrathecal amitriptyline: Antinociceptive interactions with intravenous morphine and intrathecal clonidine, neostigmine, and carbamylcholine in rats. Anesthesiology 1995, 83(5): 1036-45.
19. Schreiber, S., Backer, M.M., Pick, C.G. The antinociceptive effect of fluvoxamine. Eur Neuropsychopharmacol 1996, 6: 281-4.
20. Schreiber, S., Backer, M.M., Weizman, R., Pick, C.G. The antinociceptive effects of fluoxetine. Pain Clinic 1996, 9: 349-56.
21. Simpson, D.A. Gobapentin and venlafaxine for the treatment of painful diabetic neuropathy. J Clin Neuromuscul Dis 2001, 3: 53-62.
22. Matthews, E.A., Dickenson, A.H. A combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in a rat model of neuropathy. Anesthesiology 2002, 96(3): 633-40.