The management challenges of chronic pain: The role of antidepressants

American Journal of Therapeutics

Volumn 7, Issue 1, 2000, Pages 31-47

  Barkin, Robert L ^a   Fawcett, Jan ^b  

^a Rush Pain Center   (United States)

^b RUSH MEDICAL COLLEGE   (United States)

Author keywords

Chronic pain; Selective serotonin reuptake inhibitors; Serotonin norepinephrine reuptake inhibitors; Tricyclic antidepressants; Venlafaxine

Indexed keywords

ANTIDEPRESSANT AGENT;

CHRONIC DISEASE; DISEASE MANAGEMENT; HUMAN; PAIN; PATHOPHYSIOLOGY; REVIEW;

ANTIDEPRESSIVE AGENTS; CHRONIC DISEASE; DISEASE MANAGEMENT; HUMANS; PAIN;

EID: 0033765396     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200007010-00006     Document Type: Article

References (105)

1. Merskey H, Bogduk N: Pain terms. In: Anonymous Classification of Chronic Pain Syndromes and Definition of Pain Terms, 2nd ed. International Association for the Study of Pain Press, Seattle, 1994, 210-213.
2. Chapman CR: The emotional aspects of pain. In: Current and Emerging Issues in Cancer Pain: Research and Practice. (Eds. Chapman CR, Foley KM). Lippincott-Raven, New York, 1993, 83-98.
3. Barkin RL, Lubenow TR, Bruehl S, Husfeldt B, Ivankovich O, Barkin SJ: Management of chronic pain. Part 1. Dis Mon 1996;42:389-453.
4. Craig KD: Emotional aspects of pain. In: Textbook of Pain, 3rd ed. (Eds. Wall PD, Melzack R). Churchill Livingstone, New York, 1994, 261-274.
5. Bayer AG, Chadha JS, Farag RR, Pathy MSJ: Changing presentations of myocardial infarction with increasing old age. J Am Geriatr Soc 1986;34:263-266.
6. Barsky AJ, Hochstrasser B, Coles NA, et al: Silent myocardial ischemia: Is the person or the event silent? JAMA 1990;364:1132-1135.
7. Kauvar DR: The geriatric acute abdomen. Clin Geriatr Med 1993;9:547-558.
8. nd Annual ASHP Midyear Clinical Meeting. December 8, 1997, Atlanta, GA.
9. Casadevall A, Barkin RL, Moreno JA, Garcia A, McCutchan JA, Sanchez A, Martinez AJ: AIDS: Combating infection and enhancing quality of life. Cuban Medical Convention Symposium Proceeding, Albert Einstein College of Medicine CME.
10. Barkin RL, Richtsmeier AY: Alternative agents in pharmacologic management of sickle cell pain crisis complicated by acute pancreatitis. Am J Ther 1995;2:819-823.
11. Bowsher D: The management of central post-stroke pain. Postgrad Med J 1995;71:598-604.
12. De Wester JN: Recognizing and treating the patient with somatic manifestations of depression. J Fam Pract 1996;43(suppl):S3-S15.
13. Galer BS: Neuropathic pain of peripheral origin: Advances in pharmacologic treatment. Neurology 1995;45 (suppl 9):S17-S25.
14. Larue F, Fontaine A, Colleau SM: Underestimation and undertreatment of pain in HIV disease: Multicentre study. Brit Med J 1997;314:23-28.
15. Lister BJ: Dilemmas in the treatment of chronic pain. Am J Med 1996;101(suppl 1A):2S-5S.
16. Pappagallo M, Heinberg LJ: Ethical issues in the management of chronic nonmalignant pain. Semin Neurol 1997;17:203-211.
17. Godfrey RG: A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. Arch Intern Med 1996;156:1047-1052.
18. Addison RG: Chronic pain syndrome. Am J Med 1984;54-58.
19. Dworkin SF, Von Korff M, LeResche L: Multiple pains and psychiatric disturbance: An epidemiologic investigation. Arch Gen Psychiatry 1990;47:239-244.
20. Parmelee PA, Katz IR, Lawton MP: The relation of pain to depression among institutionalized aged. J Gerontol 1991;46:15-21.
21. Barkin RL, Leikin JB, Barkin SJ: Noncardiac chest pain: A focus upon psychogenic causes. Am J Ther 1994;1: 321-326.
22. Gruber AJ, Hudson JI, Pope HG Jr: The management of treatment-resistant depression in disorders on the interface of psychiatry and medicine. Fibromyalgia, chronic fatigue syndrome, migraine, irritable bowel syndrome, atypical facial pain, and premenstrual dysphoric disorder. Psychiatr Clin North Am 1996;19:351-369.
23. Bigos S, Bower O, Braen G, et al: Acute Low Back Problems in Adults. Clinical Practice Guideline No. 14. 1994, Rockland, MD: Agency for Healthcare Policy and Research, Public Health Service U.S. Department of Health and Human Services. AHCPR publication 95-0642.
24. Rost K, Zhang M, Fortney J, Smith J, Smith GRJ: Expenditures for the treatment of major depression. Am J Psychiatry 1998;155:883-888.
25. th ed. American Psychiatric Association, Washington, DC, 1994, 458-461.
26. th ed. American Psychiatric Association, Washington, DC, 1994, 317-392.
27. Huff J, Barkin RL: A primary care clinician's and consultant's guide to medicating for pain and anxiety associated with outpatient procedures. Am J Ther 1994; 1:186-190.
28. Barkin RL, Barkin D: Pharmacotherapeutic challenges in the elderly: Polypharmacy, drug interactions, compliance and side effect/adverse effect predictions. Anesth Today 1998;9:12-19.
29. Meyer RA, Campbell JN, Raja SN: Peripheral and neural mechanisms of nociception. In: Textbook of Pain, 3rd ed. (Eds. Wall PD, Melzack R). Churchill Livingstone, New York, 1994, 13-44.
30. Guilbaud G, Bernard JF, Besson JM: Brain areas involved in nociception and pain. In: Textbook of Pain, 3rd ed. (Eds, Wall PD, Melzack R). Churchill Livingstone, New York, 1994, 113-128.
31. Yaksh TL, Malmberg AB: Central pharmacology of nociceptive transmission. In: Textbook of Pain, 3rd ed. (Eds. Wall PD, Melzack R). Churchill Livingstone, New York, 1994, 165-200.
32. Braverman B, O'Connor C, Barkin RL: Pharmacology, physiology and anesthetic implications and antidepressants. In: Pharmacology and Physiology in Anesthetic Practice, 2nd ed. (Ed. Stoelting RC). Lippincott, Philadelphia, 1993, 1-15.
33. Bonica JJ: Anatomic and physiologic basis of nociception and pain. In: The Management of Pain, 2nd ed. (Ed. Bonica JJ). Lea and Febiger, Malvern, PA, 1990, 28-94.
34. Bonica JJ, et al: Biochemistry and modulation of nociception and pain. In: The Management of Pain, 2nd ed. (Ed. Bonica JJ). Lea and Febiger, Malvern, PA, 1990, 95-121.
35. Tarster RR: Pain resulting from central nervous system pathology (central pain). In: The Management of Pain, 2nd ed. (Ed. Bonica JJ). Lea and Febiger, Malvern, PA, 1990, 264-283.
36. LaMotte CC: Organization of dorsal horn neurotransmitter systems. In: Spinal Afferent Processing. (Ed. Yaksh TL). Plenum Press, New York, 1986, 97-116.
37. Seybold VS: Neurotransmitter receptor sites in the spinal cord. In: Spinal Afferent Processing. (Ed. Yaksh TL). Plenum Press, New York, 1986, 117-146.
38. Ruda MA: The pattern and place of nociceptive modulation in the dorsal horn: A discussion of the anatomically characterized neural circuitry of enkephalin, serotonin, and substance P. In: Spinal Afferent Processing. (Ed. Yaksh TL). Plenum Press, New York, 1986.
39. Siddall PJ, Cousins MJ: Pain mechanisms and management: An update. Clin Exp Pharmacol Physiol 1995;22: 679-688.
40. Yaksh TL: Pharmacology of the pain processing system. In: Interventional Pain Management. (Eds. Waldman SD, Winnie AP). WB Saunders, Philadelphia, 1996.
41. Bennett GF: Neuropathic pain. In: Textbook of Pain, 3rd ed. (Eds. Wall PD, Melzack R). Churchill Livingstone, New York, 1994, 201-224.
42. Chakour MC, Gibson SJ, Bradbeer M, Helme RD: The effect of age on A-delta and C fibre thermal pain perception. Pain 1996;64:143-152.
43. Melzack R: Gate control theory: On the evolution of pain concepts. Pain Forum 1996;5:128-138.
44. Gibson TP: Pharmacokinetics, efficacy, and safety of analgesia with a focus on tramadol HCL. Am J Med 1996;101(suppl 1A):47S-53S.
45. Barkin RL: Focus on tramadol: A centrally acting analgesic for moderate to moderately severe pain. Formulary 1995;30:321-325.
46. Barkin RL: Alternative dosing for tramadol aids effectiveness. Formulary 1995;30:542-543.
47. Ruoff GE: Depression in the patient with chronic pain. J Fam Pract 1996;43(suppl 6):S25-S34.
48. Dworkin RH, Gitlin MJ: Clinical aspects of depression in chronic pain patients. Clin J Pain 1991;7:79-94.
49. Philipp M, Fickinger M: Psychotropic drugs in the management of chronic pain syndromes. Pharmacopsychiatry 1993;26:221-234.
50. McQuay HJ, Moore RA: Antidepressants and chronic pain. Brit Med J 1997;314:763-764.
51. Stein WM, Read S: Chronic pain in the setting of Parkinson's disease and depression. J Pain Symptom Manage 1997;14:255-258.
52. Popp B, Portenoy RK: Management of chronic pain in the elderly: Pharmacology of opioids and other analgesic drugs. In: Pain in the Elderly. (Eds. Ferrell BR, Ferrell BA). International Association of the Study of Pain, Seattle, 1996, 21-34.
53. Barkin RL: Cancer pain treatment insights. Pharmacotherapy 1997;17:397-398.
54. Barkin RL, Barkin SJ, Barkin SA: Opiate/opioid overdose: Challenges in the emergency room which complicate management in the treatment of opiate/opioid overdose. In: Poisoning and Toxicology Compendium. (Ed. Leiken JB). Lexi-comp Inc. Americomp Pharmaceutics Association, 1997-1998, 90-91.
55. th edition. (Eds. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW). McGraw-Hill, New York, 1996, 521-555.
56. Feinmann C: Pain relief by antidepressants: Possible modes of action. Pain 1985;23:1-8.
57. RAJ PP: Practical Management of Pain, 2nd ed. Mosby Yearbook, St. Louis, 1992.
58. Kramer MS, Culter N, Feighner J, Shrivastava R, Carman J, et al: Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998 Sep 11;281:1640-1645.
59. Bryson HM, Wilde MI: Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs Aging 1996;8:459-476.
60. Eija K, Tiina T, Pertti NJ: Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain 1996;64:293-302.
61. Watson CPN: Antidepressant drugs as adjuvant analgesics. J Pain Symptom Manage 1994;9:392-405.
62. Sindrup SH: Antidepressants in pain treatment. Nord J Psychiatry 1993;47(suppl):67-73.
63. Magni G: The use of antidepressants in the treatment of chronic pain. A review of the current evidence. Drugs 1991;42:730-748.
64. De Angelis L: "Newer" versus "older" antidepressant drugs in the treatment of chronic pain syndromes. Adv Ther 1992;9:91-97.
65. Onghena P, Van Houdenhove B: Antidepressant-induced analgesia in chronic non-malignant pain: A meta-analysis of 39 placebo-controlled studies. Pain 1992;49:205-219.
66. Hunter S: Atypical facial pain - rewarding to treat. Practitioner 1994;238:186-193.
67. Atkinson JH, Grant I: Natural history of neuropsychiatric manifestations of HIV disease. Psychiatr Clin North Am 1994;17:17-33.
68. Galer BS: Painful polyneuropathy: Diagnosis, pathophysiology, and management. Semin Neurol 1994;14: 237-246.
69. Rowbotham MC: Painful polyneuropathy. Semin Neurol 1994;14:247-254.
70. Borestein D: Prevalence and treatment outcome of primary and secondary fibromyalgia in patients with spinal pain. Spine 1995;20:796-800.
71. Taylor K, Rowbotham MC: Venlafaxine hydrochloride and chronic pain. West J Med 1996;165:147-148.
72. Sindrup SH, Brosen K, Gram LF: Antidepressants in pain treatment: Antidepressant or analgesic effect. Clin Neuropharmacol 1992;15(suppl 1):636A-637A.
73. Sindrup SH, Brosen K, Gram LF: The mechanism of action of antidepressants in pain treatment: Controlled cross-over studies in diabetic neuropathy. Clin Neuropharmacol 1992;15(suppl 1 part A):380A-381A.
74. Loeser JD: Herpes zoster and postherapeutic neuralgia. Pain 1986;25:149-164.
75. Tacey BR: Effective management of chronic pain. The analgesic dilemma. Postgrad Med 1996;100:281-284, 287-293.
76. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA: A systematic review of antidepressants in neuropathic pain. Pain 1996;68:217-227.
77. Gonzales GR: Central pain: Diagnosis and treatment strategies. Neurology 1995;45:S11-S16.
78. Coderre TJ, Katz J, Vaccarino AL, Melzack R: Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence. Pain 1993;52:259-285.
79. Richardson PH: Meta-analysis of antidepressant-induced analgesia in chronic pain: Comment. Pain 1993; 52:247.
80. Cookson J: Side effects of antidepressants. Br J Psychiatry 1993;163(suppl 20):20-24.
81. Eschalier A, Ardid D, Coudore F: Pharmacological studies of the analgesic effect of antidepressants. Clin Neuropharmacol 1992;15(suppl 1 part A):373A-374A.
82. Zitman FG, Linssen ACG, Edelbroek PM, Yen Kempen GM: Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain. Clin Neuropharmacol 1992;15(suppl 1 part A):377A-378A.
83. Sindrup SH, Gram LF, Brøsen K, Eshøj O, Mogensen EF: The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990;42:135-144.
84. Augustin BG, Cold JA, Jann MW: Venlafaxine and nefazodone, two pharmacologically distinct antidepressants. Pharmacotherapy 1997;17:511-530.
85. Tamler MS, Meerschaert JR: Pain management of fibromyalgia and other chronic pain syndromes. Phys Med Rehabil Clin N Am 1996;7:549-560.
86. Rowbotham MC: Chronic pain: From theory to practical management. Neurology 1995;45:S5-S10.
87. Davis JM, Glassman AH: Antidepressant drugs. In: Comprehensive Textbook of Psychiatry. (Eds. Kaplan HI, Sadock BJ). Williams and Wilkins, New York, 1989, 1627-1654.
88. Songer DA, Schulte H: Venlafaxine for the treatment of chronic pain. Am J Psychiatry 1996;153:737.
89. Taylor K, Rowbotham MC: Venlafaxine hydrochloride and chronic pain. West J Med 1996;165:147-148.
90. Holliday SM, Benfield P: Venlafaxine: A review of its pharmacology and therapeutic potential in depression. Drugs 1995;49:280-294.
91. Yunus MB: Fibromyalgia syndrome: Is there any effective therapy? Consultant 1996;1279-1285.
92. Dwight M, Arnold L, O'Brien H, Metzger R, Morris-Park E: Venlafaxine treatment of fibromyalgia. Psychopharmacol Bull 1996;32:435.
93. Barkin RL: Attributes, advantages of venlafaxine overlooked. Formulary 1998;33:74-75.
94. Cerruto L: Venlafaxine joins ranks of psychotropic therapies to treat fibromyalgia. Prim Psychiatry 1996;1: 62-66.
95. Rani PU, Naidu MUR, Prasad VBN, Rao TRK, Shobha JC: An evaluation of antidepressants in rheumatic pain conditions. Anesth Analg 1996;83:371-375.
96. Byrne SE, Rothschild AJ: Loss of antidepressant efficacy during maintenance therapy: Possible mechanisms and treatments. J Clin Psychiatry 1998;59:279-288.
97. Barkin RL, Schwer W, Barkin SJ: Recognition and management of depression in primary care: A focus upon the elderly: A pharmacotherapeutic overview of the selection process among the traditional and new antidepressants. Am J Ther 1999, in press.
98. Cohen LJ: Rational drug use in the treatment of depression. Pharmacotherapy 1997;17:45-61.
99. Montgomery SA: Venlafaxine: A new dimension in antidepressant pharmacotherapy. J Clin Psychiatry 1993; 54:119-126.
100. Feighner JP: The role of venlafaxine in rational antidepressant therapy. J Clin Psychiatry 1994;55(9, suppl A): 62-68.
101. DeVane CL: Pharmacokinetics of the newer antidepressants: Clinical relevance. Am J Med 1994;97(suppl 6A): 6A-13S-6A-23S.
102. Barkin RL, Barkin DS, Barkin SJ, Barkin SA: Opiate, opioids, and centrally acting analgesics and drug interactions: The emerging role of the psychiatrist. Med Update Psych November/December 1998; 3(6):172-175.
103. Bazine S, Benefield WH: Psychotropic Drug Directory 1997-1998. Quay Books & Organon, West Orange, NJ, 1997-1998, 214-216.
104. Cohen LJ, De Vane CL: Clinical implications of antidepressant pharmacokinetics and pharmacogenetics. Ann Pharmacother 1996;30:1471-1480.
105. Sternbach H: The serotonin syndrome. Am J Psychiatry 1991;148:705-713.