CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes

European Journal of Cell Biology

Volumn 82, Issue 5, 2003, Pages 253-261

  Peiretti, Alexandra ^a   Baghdassarian, Nathalie ^a   Gerland, Luc M ^a,b   Ffrench, Patrick ^b   Bryon, Paul André ^a,b   Magaud, Jean Pierre ^a,b   Ffrench, Martine ^a,b  

^a UNIVERSITÉ LYON 1   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

CDK2 expression; CDK2 protein complexes; Glucocorticoid; Lymphocytes; S phase lengthening

Indexed keywords

CYCLIN A; CYCLIN D2; CYCLIN E; CYCLOHEXIMIDE; DEXAMETHASONE; GLUCOCORTICOID; HISTONE H1; MESSENGER RNA; PROTAMINE KINASE; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN;

ARTICLE; CELL CYCLE S PHASE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION;

EID: 0037809495     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00298     Document Type: Article

References (27)

1. Baghdassarian, N., Catallo, R., Mahly, M. A., Ffrench, P., Chizat, F., Bryon, P. A., Ffrench, M. (1998): Glucocorticoids induce G1 as well as S-phase lengthening in normal human stimulated lymphocytes: differential effects on cell-cycle regulatory proteins. Exp. Cell Res. 240, 263-273.
2. kip1 in the G1 - and S/G2-phase lengthening mediated by glucocorticoids in normal human lymphocytes. Cell Growth Differ. 10, 405-412.
3. Boumpas, D. T., Anastassiou, E. D., Older, S. A., Tsokos, G. C., Nelson, D. L., Balow, J. E. (1991): Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J. Clin. Invest. 87, 1739-1747.
4. kip1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18, 1571-1583.
5. Chomczynski, P., Sacchi, N. (1987): Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. Corroyer, S., Nabeyrat, E., Clement, A. (1997): Involvement of the cell cycle inhibitor CIP1/WAF1 in lung alveolar epithelial cell growth arrest induced by glucocorticoids. Endocrinology 138, 3677-3685.
7. Dietrich, C., Wallenfang, K., Oesch, F., Wieser, R. (1997): Translocation of CDK2 to the nucleus during G1-phase in PDGF-stimulated human fibroblasts. Exp. Cell Res. 232, 72-78.
8. Dulic, V., Stein, G. H., Far, D. F., Reed, S. I. (1998): Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol. Cell. Biol. 18, 546-557.
9. Eastman-Recks, S. B., Vedeckis, W. V. (1986): Glucocorticoid inhibition of c-myc, c-myb, c-ki-ras in a mouse lymphoma cell line. Cancer Res. 46, 2457-2462.
10. Elledge, S. J., Spottswood, M. R. (1991): A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Egl. EMBO J. 10, 2653-2659.
11. Ernst, P., Killmann, S. A. (1970): Perturbation of generation cycle of human leukemic blast cells by cytostatic therapy in vivo: effect of corticosteroids. Blood 36, 689-696.
12. Fagot, D., Buquet-Fagot, C., Mester, J. (1991): Antimitogenic effects of dexamethasone in chemically transformed mouse fibroblasts. Endocrinology 129, 1033-1041.
13. 3 cell cycle. J. Steroid Biochem. 28, 345-347.
14. Firpo, E. J., Koff, A., Solomon, M. J., Roberts, J. M. (1994): Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14, 4889-4901.
15. cip1. Genes Dev. 12, 3882-3888.
16. LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., Harlow, E. (1997): New functional activities for p21 family of CDK inhibitors. Genes Dev. 11, 847-862.
17. kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570-573.
18. Pagano, M., Pepperkok, R., Lukas, J., Baldin, V., Ansorge, W., Bartek, J., Draetta, G. (1993): Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol. 121, 101-111.
19. Cip1. Mol. Endocrinol. 11, 577-586
20. Reisman, D., Thompson, E. A. (1995): Glucocorticoid regulation of cyclin D3 gene transcription and mRNA stability in lymphoid cells. Mol. Endocrinol. 9, 1500-1509.
21. Rhee, K., Reisman, D., Bresnahan, W., Thompson, E. A. (1995): Glucocorticoid regulation of G1 cyclin-dependent kinase genes in lympboid cells. Cell Growth Differ. 6, 691-698.
22. Rupprecht, R., Wodarz, N., Kornhuber, J., Schmitz, B., Wild, K., Braner, H. U., \ Müller, O. A., Riederer, P. (1990): In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in man: relationship to glucocorticoid receptors. Neuropsychobiology 24, 61-66.
23. Sherr, C. J. (1993): Mammalian G1 cyclins. Cell 73, 1059-1065.
24. 1 cyclindependent kinases. Genes Dev. 9, 1149-1163.
25. Welch, P. J., Wang, J. Y. (1992): Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc. Natl. Acad. Sci. USA 89, 3093-3097.
26. Wyllie, A. H. (1980): Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556.
27. Zhang, H., Hannon, G. J., Beach, D. (1994): p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8, 1750-1758.