Distribution of de novo synthesized betaine in rat kidney: Role of renal synthesis on medullary betaine accumulation

American Journal of Physiology - Renal Physiology

Volumn 272, Issue 1 41-1, 1997, Pages

  Moeckel, Gilbert W ^a   Lien, Yeong Hau H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Dimethylaminoethanol; Osmolytes; Osmoregulation

Indexed keywords

BETAINE;

ANIMAL EXPERIMENT; ARTICLE; CELL VOLUME; FLUID BALANCE; HYDRATION; KIDNEY MEDULLA; MALE; NONHUMAN; OSMOREGULATION; PRIORITY JOURNAL; RAT;

EID: 0030771438     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.272.1.f94     Document Type: Article

References (26)

1. Acara, M., and B. Rennick. Renal tubular transport of choline: Modifications caused by intrarenal metabolism. J. Pharmacol. Exp. Ther. 182: 1-12, 1972.
2. Acara, M., and B. Rennick. Regulation of plasma choline by the renal tubule: bidirectional transport of choline. Am. J. Physiol. 225: 1123-1128, 1973.
3. Allen, R., S. Stabler, and J. Lindenbaum. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 42: 1448-1460, 1993.
4. Bagnasco, S., R. Balaban, H. Fales, Y.-M. Yang, and M. Burg. Predominant osmotically active organic solutes in rat and rabbit renal medullas. J. Biol. Chem. 261: 5872-5877, 1986.
5. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72: 248-254, 1977.
6. 2H NMR and MRI study. NMR Biomed. 3: 173-177, 1990.
7. Grossman, E. B., and S. C. Hebert. Renal inner medullary choline dehydrogenase activity: characterization and modulation. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F107-F112, 1989.
8. Gullans, S. R., J. D. Blumenfeld, J. A. Balschi, M. Kaleta, R. M. Brenner, C. W. Heilig, and S. C. Hebert. Accumulation of major organic osmolytes in rat renal inner medulla in dehydration. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F626-F634, 1988.
9. Landfald, B., and A. R. Strøm. Choline-glycine-betaine pathway confers a high level of osmotic tolerance in Escherica coli. J. Bacteriol. 165: 849-855, 1986.
10. Lohr, J., and M. Acara. Effect of dimethylaminoethanol, an inhibitor of betaine production, on the disposition of choline in the rat kidney. J. Pharmacol. Exp. Ther. 252: 154-158, 1990.
11. Lohr, J., M. A. Pochal, and M. Acara. Osmoregulatory betaine uptake by rat renal medullary slices. J. Am. Soc. Nephrol. 2: 879-884, 1991.
12. Moeckel, G. W., H. G. Dasser, T. J. Chen, M. Schmolke, and W. G. Guder. Bicarbonate dependent betaine synthesis in rat kidney. In: Renal Ammoniagenesis and Interorgan Cooperation in Acid-Base Homeostasis, edited by A. Tizianello. Basel, Switzerland: Karger, 1994, vol. 110, 46-53.
13. 1 cells. Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35): F512-F515, 1994.
14. Nakanishi, T., R. J. Turner, and M. B. Burg. Osmoregulation of betaine transport in mammalian renal medullary cells. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F1061-F1067, 1990.
15. Nakanishi, T., T. Yamada, T. Iida, O. Uyama, and M. Sugita. Betaine excretion increases by water loading after dehydration. Contrib. Nephrol. 95: 264-271, 1991.
16. Pummer, S., Y. H. Lien, G. W. Moeckel, K. Voelker, and S. Silbernagl. Characteristics and localization of betaine reabsorption in rat kidney. (Abstract). XIIIth International Congress of Nephrology, 1995.
17. Streumer-Svobodova, Z., and Z. Drahota. The development of oxidative enzymes in rat liver mitochondria. Physiol. Bohemoslov. 26: 525-534, 1977.
18. Takenaka, M., A. S. Preston, H. M. Kwon, and J. S. Handler. The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. J. Biol. Chem. 269: 29379-29381, 1994.
19. --dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene. J. Clin. Invest. 91: 1604-1607, 1993.
20. Wirthensohn, G., and W. G. Guder. Studies on renal choline metabolism and phosphatidylcholine synthesis. In: Biochemistry of Kidney Function, edited by F. Morel. Amsterdam: Elsevier, 1982, 119-128.
21. Wirthensohn, G., S. Lefrank, M. Schmolke, and W. G. Guder. Regulation of organic osmolyte concentration in tubules from rat renal inner medulla. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F128-F135, 1989.
22. Wunz, T. M., and S. H. Wright. Betaine transport in rabbit renal brush-border membrane vesicles. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F948-F955, 1993.
23. Yamauchi, A., H. M. Kwon, S. Uchida, A. S. Preston, and J. S. Handler. Myo-inositol and betaine transporters regulated by tonicity are basolateral in MDCK cells. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F197-F202, 1991.
24. --dependent betaine transporter that is regulated by hypertonicity. J. Biol. Chem. 267: 649-652, 1992.
25. Yancey, P. H., M. E. Clark, S. C. Hand, R. D. Bowlus, and G. N. Somero. Living with water stress: evolution of osmolyte systems. Science Wash. DC 217: 1214-1222, 1982.
26. Yancey, P. H., and G. N. Somero. Methylamine osmoregulatory solutes of elasmobranch fishes counteract urea inhibition of enzymes. J. Exp. Zool. 212: 205-213, 1980.