Serum homocysteine levels are increased in women with gestational diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 52, Issue 6, 2003, Pages 720-723

  Seghieri, Giuseppe ^a,b   Breschi, Maria C ^a,b   Anichini, Roberto ^a,b   De Bellis, Alessandra ^a,b   Alviggi, Lorenzo ^a,b   Maida, Ivana ^a,b   Franconi, Flavia ^a,b  

^a Spedali Riuniti ^*  (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BIOCHEMICAL MARKER; CYANOCOBALAMIN; FOLIC ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; LIPID; TRIACYLGLYCEROL; URIC ACID; SERUM ALBUMIN;

ADULT; AGE; ALBUMIN BLOOD LEVEL; AMINO ACID BLOOD LEVEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLIC ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; ORAL GLUCOSE TOLERANCE TEST; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; VITAMIN BLOOD LEVEL; BLOOD; BLOOD PRESSURE; CASE CONTROL STUDY; GLUCOSE TOLERANCE TEST; MALE; PATHOPHYSIOLOGY;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; FEMALE; FOLIC ACID; GLUCOSE TOLERANCE TEST; HOMOCYSTEINE; HUMANS; MALE; PREGNANCY; SERUM ALBUMIN; URIC ACID; VITAMIN B 12;

EID: 0037804657     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(03)00032-5     Document Type: Article

References (27)

1. Walker MC, Smith GN, Perkins SL, et al: Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol 180:660-664, 1999
2. Bonnette RE, Caudill MA, Boddie AM, et al: Plasma homocyst(e)ine concentrations in pregnant and nonpregnant women with controlled folate intake. Obstet Gynecol 92:167-170, 1998
3. Vollset SE, Refsum H, Irgens LM, et al: Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: The Hordaland Homocysteine study. Am J Clin Nutr 71:962-968, 2000
4. Nelen WL, Blom HJ, Steegers EA, et al: Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol 95:519-524, 2000
5. Buysschaert M, Dramais AS, Wallemacq PE, et al: Hyperhomocysteinemia in type 2 diabetes: Relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes Care 23:1816-1822, 2000
6. Laivuori R, Kaaja R, Turpeinen U, et al: Plasma homocysteine elevated and inversely related to insulin sensitivity in preeclampsia. Obstet Gynecol 93:489-493, 1999
7. Sorensen TK, Malinow MR, Williams MA, et al: Elevated second-trimester serum homocysteine levels and subsequent risk of preeclampsia. Gynecol Obstet Invest 48:98-103, 1999
8. Chambers JC, Seddon MDI, Shah S, et al: Homocysteine - A novel risk factor for vascular disease. J R Soc Med 94:10-13, 2001
9. American Diabetes Association: Clinical practice recommendations 2001. Diabetes Care 24:S77-79, 2001 (suppl 1)
10. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470, 1999
11. Kirwan JP, Huston-Presley H, Kalhan SC, et al: Clinically useful estimates of insulin sensitivity during pregnancy. Diabetes Care 24:1602-1607, 2001
12. SAS Software. SAS/STAT Guide for Personal Computers, Version 6. Cary, NC, SAS Institute Inc, 1987
13. Emoto M, Kanda H, Shoji T, et al: Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. Diabetes Care 24:533-538, 2001
14. Cotter AM, Molloy AM, Scott JM, et al: Elevated plasma homocysteine in early pregnancy: A risk factor for the development of severe preeclampsia. Am J Obstet Gynecol 185:781-785, 2001
15. Sheu WH, Lee WJ, Chen YT: Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects. Am J Hypertens 13:14-20, 2000
16. Kaplan JS, Iqbal S, England BG, et al: Is pregnancy in diabetic women associated with folate deficiency? Diabetes Care 22:1017-1021, 1999
17. Godsland IF, Rosenkiewicz JR, Proudler AJ, et al: Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men. J Clin Endocrinol Metab 86:719-723, 2001
18. Abbasi F, Facchini F, Humphreys MH, et al: Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis 146:175-178, 1999
19. Fonseca VA, Mudaliar S, Schmidt B, et al: Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism 47:686-689, 1998
20. Hoogeveen EK, Kostense PJ, Eysink PE, et al: Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: The Hoorn study. Arch Intern Med 160:2984-2990, 2000
21. Jager A, Kostense PJ, Nijpels G, et al: Serum homocysteine levels are associated with the development of microalbuminuria: The Hoorn study. Artherioscler Thromb Vasc Biol 21:74-81, 2001
22. Powers RW, Evans RW, Majors AK, et al: Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol 179:1605-1611, 1998
23. Knock GA, McCarthy AL, Lowy C, et al: Association of gestational diabetes with abnormal maternal vascular endothelial function. Br J Obstet Gynaecol 104:229-234, 1997
24. Kaaja R, Laivuori H, Laakso M, et al: Evidence of a state of increased insulin resistance in preeclampsia. Metabolism 48:892-896, 1999
25. Martinez Abundis E, Gonzalez Ortiz M, Quinones Galvan A, et al: Hyperinsulinemia in glucose-tolerant women with preeclampsia. A controlled study. Am J Hypertens 9:610-614, 1996
26. Rajkovic A, Catalano PM, Malinow MR: Elevated homocysteine levels in preeclampsia. Obstet Gynecol 90:168-171, 1997
27. Sanchez SE, Zhang C, Rene Malinow M, et al: Plasma folate, vitamin B12, and homocysteine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 153:474-480, 2001