C-peptide has no effect on forearm blood flow during local hyperinsulinaemia in healthy humans

British Journal of Clinical Pharmacology

Volumn 55, Issue 6, 2003, Pages 526-530

  Langenberger, Herbert ^a   Schaller, Georg ^a   Pleiner, Johannes ^a   Mittermayer, Friedrich ^a   Bayerle Eder, Michaela ^a   Wolzt, Michael ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

C peptide; Forearm blood flow; Insulin; Vasodilation

Indexed keywords

C PEPTIDE; INSULIN;

ADULT; ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG POTENCY; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; LOW DRUG DOSE; MALE; NORMAL HUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; VASODILATATION;

ADULT; BLOOD FLOW VELOCITY; C-PEPTIDE; FOREARM; HUMANS; INSULIN; MALE; VASODILATION; VASODILATOR AGENTS;

EID: 0037789580     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2003.01808.x     Document Type: Article

References (31)

1. Hagen C. Studies on the subunits of the human glycoprotein hormones in relation to reproduction. Scand J Clin Lab Invest Suppl 1977; 148: 1-19.
2. Hoogwerf BJ, Bantle JP, Gaenslen HE et al. Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagons in healthy subjects. Metabolism 1986; 35: 122-125.
3. Wahren J, Ekberg K, Johansson J et al. Role of C-peptide in human physiology. Am J Physiol Endocrinol Metab 2000; 278: E759-E768.
4. Huang DY, Richter K, Breidenbach A, Vallon V. Human C-pepride acutely lowers glomerular hyperfiltration and proteinuria in diabetic rats: a dose-response study. Naunyn Schmiedebergs Arch Pharmacol 2002; 365: 67-73.
5. Samnegard B, Jacobson SH, Jaremko G, Johansson BL, Sjoquist M. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int 2001; 60: 1258-1265.
6. Forst T, Kunt T, Pfutzner A, Beyer J, Wahren J. New aspects on biological activity of C-peptide in IDDM patients. Exp Clin Endocrinol Diabetes 1998; 106: 270-276.
7. Johansson BL, Kernell A, Sjoberg S, Wahren J. Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J Clin Endocrinol Metab 1993; 77: 976-981.
8. Johansson BL, Borg K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia 1996; 39: 687-695.
9. Fernqvist-Forbes E, Johansson BL, Eriksson MJ. Effects of C-peptide on forearm blood flow and brachial artery dilation in patients with type I diabetes mellitus. Acta Physiol Scand 2001; 172: 159-165.
10. Wahren J, Johansson BL, Wallberg-Henriksson H. Does C-peptide have a physiological role? Diabetologia i994; 37 (Suppl 2): S99-S107.
11. Johansson BL, Linde B, Wahren J. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type I (insulin-dependent) diabetic patients. Diabetologia 1992; 35: 1151-1158.
12. Jansson L. Effects of C-peptide on splanchnic blood flow in anaesthetised rats. Med Sci Res 1995; 23: 157-158.
13. Jensen ME, Messina EJ. C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in the presence of insulin. Am J Physiol 1999; 276: H1223-H1228
14. Kerchner J, Colaluca DM, Juhl RP. Effect of whole blood on insulin adsorption onto intravenous infusion systems. Am J Hosp Pharm 1980; 37: 1323-1325.
15. Ueda S, Petrie JR, Cleland SJ, Elliott HL, Connel JM. The vasodilating effect of insulin is dependent on local glucose uptake: a double blind placebo-controlled study. J Clin Endocrinol Metab 1998; 83: 2126-2131.
16. Wolzt M, Schmetterer L, Rheinberger A et al. Comparison of non-invasive methods for the assessment of haemodynamic drug effects in healthy male and female volunteers: sex differences in cardiovascular responsiveness. Br J Clin Pharmacol 1995; 39: 347-359.
17. Hokanson DE, Sumner DS, Strandness DE Jr. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng 1975; 22: 25-29.
18. Benjamin N, Calver A, Collier J, Robinson B, Vallance P, Webb D. Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertensio, 1995; 25: 918-923.
19. Tack CJ, Schefman AE, Willems JL, Thien T, Lutterman JA, Stairs P. Direct vasodilator effects of physiological hyperinsulinaemia in human skeletal muscle. Eur J Clin Invest 1996; 26: 772-778.
20. Lind L, Fugmann A, Millgard J, Berne C, Lithell H. Insulin-mediated vasodilatadon, but not glucose uptake or endothelium-mediated vasodilatadon, is enhanced in young females compared with males. Clin Sci 2002; 102: 241-246.
21. Fossum E, Hoieggen A, Moan A, Rostrup M, Nordby G, Kjeldsen SE. Relationship between insulin sensitivity and maximal forearm blood flow in young men. Hypertension 1998; 32: 838-843.
22. Cleland SJ, Petrie JR, Ueda S, Elliott H, Connell J. Insulin-mediated vasodilation and glucose uptake are functionally linked in humans. Hypertension 1999; 33: 554-558.
23. Johansson BL, Pernow J. C-peptide potentiates the vasoconstrictor effect of neuropeptide Y in insulin-dependent diabetic patients. Acta Physiol Scand 1999; 165: 39-44.
24. Rigler R, Pramanik A, Jonasson P et al. Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci USA 1999; 96: 13318-13323.
25. Ido Y, Vindigni A, Chang K et al. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 1997; 277: 563-566.
26. Johansson J, Ekberg K, Shafqat J et al. Molecular effects of proinsulin C-peptide Biochem Biophys Res Commun 2002; 295: 1035-1040.
27. Ohtomo Y, Aperia A, Sahlgren B, Johansson BL, Wahren J. C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. Diabetologia 1996; 39: 199-205.
28. Kunt T, Schneider S, Pfutzner A et al. The effect of human proinsulin C-peptide on erythrocyte deformability in patients with Type 1 diabetes mellitus. Diabetologia 1999; 42: 465-471.
29. Cardillo C, Kilocyne CM, Nambi SS, Cannon RO, Quon MJ, Panza JA. Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm. Hypertension 1998; 32: 740-745.
30. Hausberg M, Hoffman RP, Somers VK, Sinkey CA, Mark AL, Anderson EA. Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects. Hypertension 1997; 29: 700-705.
31. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 1991; 87: 2246-2252.