Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects

Hypertension

Volumn 29, Issue 3, 1997, Pages 700-705

  Hausberg, Martin ^a   Hoffman, Robert P ^a   Somers, Virend K ^a   Sinkey, Christine A ^a   Mark, Allyn L ^a   Anderson, Erling A ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

blood pressure; elderly; insulin; sympathetic nerve activity; vascular resistance

Indexed keywords

ADRENALIN; HUMAN INSULIN; NORADRENALIN;

AGED; AGING; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE REGULATION; CARDIOVASCULAR EFFECT; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN INFUSION; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; SYMPATHETIC NERVE; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0031037764     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.29.3.700     Document Type: Article

References (38)

1. Anderson EA, Balon TW, Hoffman RP, Sinkey CA, Mark AL. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension. 1992;19:621-627.
2. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest. 1991;87:2246-2252.
3. Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal men. Diabetes. 1981;30:219-225.
4. Vollenweider P, Randin D, Tappy L, Jequier E, Nicod P, Scherrer U. Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest. 1994; 93:2365-2371.
5. Landsberg L. Obesity and hypertension: experimental data. J Hypertens. 1992;10(suppl 7):S195-S201.
6. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607.
7. Rocchini AP. Insulin resistance and blood pressure regulation in obese and nonobese subjects. Hypertension. 1991;17:837-842. Special lecture.
8. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest. 1990;85:1844-1852.
9. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 1992;41:1076-1083.
10. Rowe JW, Minaker KL, Pallotta JA. Characterization of the insulin resistance of aging. J Clin Invest. 1983;71:1581-1587.
11. Gumbiner B, Thorburn AW, Ditzler TM, Bulacan F, Henry RR. Role of impaired intracellular glucose metabolism in the insulin resistance of aging. Metabolism. 1992;41:1115-1121.
12. Meneilly GS, Elliot T, Bryer-Ash M, Floras JS. Insulin-mediated increase in blood flow is impaired in the elderly. J Clin Endocrinol Metab. 1995;80:1899-1903.
13. Boden G, Chen X, DeSantis RA, Kendrick Z. Effects of age and body fat on insulin resistance in healthy men. Diabetes Care. 1993; 16:728-733.
14. Ziegler MG, Lake CR, Kopin IJ. Plasma norepinephrine increases with age. Nature. 1976;261:333-335.
15. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence on muscle sympathetic nerve activity at rest in healthy humans. Hypertension. 1993;21:498-503.
16. Iwase S, Mano T, Watanabe T, Saito M, Kobayashi F. Age-related changes of sympathetic outflow to muscles in humans. J Gerontol. 1991;46:M1-M5.
17. Young JB, Rowe JW, Pallotta JA, Sparrow D, Landsberg L. Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjects. Metabolism. 1980; 29:532-539.
18. Fleg JL, Tzankoff SP, Lakatta KG. Age-related augmentation of plasma catecholamine during dynamic exercise in healthy males. J Appl Physiol. 1985;59:1033-1039.
19. Sowers JR, Rubenstein LZ, Stern N. Plasma norepinephrine responses to posture and isometric exercise increase with age in the absence of obesity. J Gerontol. 1983;38:315-317.
20. Palmer GJ, Ziegler MG, Lake CR. Response of norepinephrine and blood pressure to stress increases with age. J Gerontol. 1978;33. 482-487.
21. National High Blood Pressure Education Program Working Group. National high blood pressure education program working group report on hypertension in the elderly. Hypertension. 1994;23:275-285.
22. Pollock ML, Jackson AS. Research progress invalidation of clinical methods of assessing body composition. Med Sci Sports Exer. 1984; 16:606-615.
23. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28:1039-1057.
24. Siggard-Anderson J. Venous occlusion plethysmography on the calf. Dan Med Bull. 1970;17:1-68.
25. Hagbarth KE, Vallbo AB. Pulse and respiratory grouping of sympathetic impulses in human muscle nerves. Acta Physiol Scand. 1968;74:96-108.
26. Hausberg M, Mark AL, Hoffman RP, Sinkey C, Anderson EA. Dissociation of sympathoexcitatory and vasodilator effects of modestly elevated plasma insulin levels. J Hypertens. 1995;13:1015-1021.
27. Yalow RS, Berson SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960;39:1157-1175.
28. Minaker KL, Rowe JW, Young JB, Sparrow D, Pailotta JA, Landsberg L. Effect of age on insulin stimulation of sympathetic nervous system activity in men. Metabolism. 1982;31:1181-1184.
29. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 1994;94:2511-2515.
30. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. J Clin Invest. 1994;94:1172-1179.
31. Kung CF, Lüscher TF. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 1995;25:194-200.
32. Celermajer DS, Sorensen KE, Spiegelthaler DJ, Georgakompoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24:471-476.
33. Corretti MC, Plotnick GD, Vogel RA. The effects of age and gender on brachial artery endothelium-dependent vasoactivity are stimulus-dependent. Clin Cardiol. 1995;18:471-476.
34. Joannides R, Haefeli W, Linder L, Richard V, Bakkali EH, Thuillez C, Lüscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;91:1314-1319.
35. Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelium dependent vasodilation in forearm resistance vessels of humans. Hypertension. 1996;27:849-853.
36. Baron AD, Brechtel G. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol. 1993;265: E61-E67.
37. Moan A, Høieggen A, Nordby G, Eide I, Kjeldsen SE. Evidence against activation of the sympathetic nervous system by insulin. Proc 7th European Meeting on Hypertension, Ricerca Scietifica ed Educazione Permanente. 1995;suppl 103:126. Abstract 552.
38. Lipsitz LA, Marks ER, Koestner J, Jonsson PV, Wei JY. Reduced susceptibility to syncope during postural tilt in old age: is beta-blockade protective? Arch Intern Med. 1989;149:2709-2712.