Influence of lipopolymer concentration on liposome degradation and blood clearance

International Journal of Pharmaceutics

Volumn 183, Issue 1, 1999, Pages 13-16

  Vermehren, C ^a   Jorgensen K ^a,b   Frokjaer, S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Blood clearance; Lipopolymer concentration; Liposome degradation

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; MACROGOL; PHOSPHOLIPASE A2; PHOSPHOLIPID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DEGRADATION; DRUG DEGRADATION; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; REACTION ANALYSIS; THIN LAYER CHROMATOGRAPHY;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANIMALS; LIPOSOMES; METABOLIC CLEARANCE RATE; MICE; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPASES A; POLYETHYLENE GLYCOLS;

EID: 0033035881     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00051-4     Document Type: Conference Paper

References (15)

1. Bach A.C., Férézou J., Frey A. Phospholipid-rich particles in commercial parenteral fat emulsions. An overview. Prog. Lipid Res. 35:1996;133-153.
2. Blume G., Cevc G. Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta. 1029:1990;91-97.
3. Blume G., Cevc G. Molecular mechanism of the lipid vesicle longevity in vivo. Biochim. Biophys. Acta. 1146:1993;157-168.
4. Chonn A., Cullis P.R. Recent advances in liposomal drug-delivery systems. Curr. Opin. Biotechnol. 6:1995;698-708.
5. 2. FASEB. J. 8:1994;916-924.
6. Hansen H.S., Vinggard A.M., Lauritzen L., Vermehren C., Strand A.M. A general view on mammalian phopholipases. TemaNord. 624:1995;221-227.
7. 2 activity and physical properties of lipid-bilayer substrates. Methods Enzymol. 286:1997;168-190.
8. 2 and regulation of interfacial activation: hopping versus scooting. Biochim. Biophys. Acta. 1002:1989;127-156.
9. Lasic D.D., Martin F. Stealth Liposomes. 1995;CRC Press, Boca Raton, FL.
10. 2 at the transition temperature. Biochim. Biophys. Acta. 345:1974;253-256.
11. Senior J.H. Fate and behavior of liposomes in vivo: a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst. 3:1987;123-193.
12. Sharma A., Sharma U.S. Liposomes in drug delivery: progress and limitations. Int. J. Pharmaceut. 154:1997;123-140.
13. Vance D.E., Vance J. Biochemistry of Lipids, Lipoproteins and Membranes. 1991;Elsevier, Amsterdam.
14. 2 activity towards lipopolymer-containing liposomes. Biochim. Biophys. Acta. 1373:1998;27-36.
15. Woodle M.C., Lasic D.D. Sterically stabilized liposomes. Biochim. Biophys. Acta. 1113:1992;171-199.