Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents

Journal of Organic Chemistry

Volumn 68, Issue 11, 2003, Pages 4170-4178

  Chen, Jiong J ^a,b   Drach, John C ^a   Townsend, Leroy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; ISOMERIZATION; OXIDATION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

WITTIG REACTIONS;

ORGANIC COMPOUNDS;

1 (2 AMINO 4,5 DICHLOROPHENYL) 2,5 ANHYDRO 6 O (TERT BUTYLDIMETHYLSILYL) 3,4 O ISOPROPYLIDENE DEXTRO ALLOSE; 2 BROMO 5,6 DICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; 2 BROMO 6,7 DICHLORO 4 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE; 2,5 ANHYDRO 1 BROMO 6 O (TERT BUTYLDIMETHYLSILYL) 1 DEOXY 1 (4,5 DICHLORO 2 NITROPHENYL) 3,4 O ISOPROPYLIDENE DEXTRO ALLITOL; 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; 4 (ALPHA DEXTRO RIBOFURANOSYL) 2,6,7 TRICHLOROQUINOLINE; 4 (BETA DEXTRO RIBOFURANOSYL) 2,6,7 TRICHLOROQUINOLINE; 4 [5 O (TERT BUTYLDIMETHYLSILYL) 2,3 O ISOPROPYLIDENE ALPHA DEXTRO RIBOFURANOSYL] 6,7 DICHLOROQUINOLIN 2 ONE; 6 O (TERT BUTYLDIMETHYLSILYL) 1 (4,5 DICHLORO 2 NITROPHENYL) 1,2 DIDEOXY 3,4 O ISOPROPYLIDENE DEXTRO ALLO 1 ENITOL; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; NUCLEOSIDE DERIVATIVE; POLYHALO DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HALOGENATION; ISOMERISM; OXIDATION; STEREOCHEMISTRY; WITTIG REACTION;

ANTIVIRAL AGENTS; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOMEGALOVIRUS; FIBROBLASTS; HERPESVIRUS 1, HUMAN; HUMANS; HYDROCARBONS, HALOGENATED; INDICATORS AND REAGENTS; INHIBITORY CONCENTRATION 50; KB CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NUCLEOSIDES; QUINOLINES; STEREOISOMERISM;

EID: 0037764930     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020643s     Document Type: Article

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