Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains

EMBO Reports

Volumn 4, Issue 4, 2003, Pages 412-418

  Yeung, Man Lung ^a   Tam, Tammy S M ^a   Tsang, Anthony C C ^a   Yao, Kwok Ming ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; EPITOPE; INTERLEUKIN 16; PROTEIN PDZ DOMAIN CONTAINING 3; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; PDZ PROTEIN; PDZD2 PROTEIN;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM; GENE MUTATION; GENETIC TRANSFECTION; MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN SECRETION; RAT; SEQUENCE HOMOLOGY; WESTERN BLOTTING; ANIMAL CELL; CELLULAR DISTRIBUTION; MUTATION; PDZ DOMAIN; PROTEIN CLEAVAGE;

EID: 0037764784     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor804     Document Type: Article

References (18)

1. Chaib, H., Rubin, M.A., Mucci, N.R., Li, L., Taylor, J.M.G., Day, M.L., Rhim, J.S. & Macoska J.A. (2001) Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors. Cancer Res., 61, 2390-2394.
2. +T lymphocytes and monocytes. J. Immunol., 138, 3817-3823.
3. Cruikshank, W.W., Kornfeld, H. & Center, D.M. (2000) Interleukin-16. J. Leukoc. Biol., 67, 757-766.
4. Deguchi, M., Iizuka, T., Hata, Y., Nishimura, W., Hirao, K., Yao, I., Kawabe, H. & Takai, Y. (2000) PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/δ-catenin and p0071. J. Biol. Chem., 275, 29875-29880.
5. Earnshaw, W.C., Martins, L.M. & Kaufmann, S.H. (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem., 68, 383-424.
6. Grootjans, J.J., Reekmans, G., Ceulemans, H. & David, G. (2000) Syntenin-syndecan binding requires syndecan synteny and the co-operation of both PDZ domains of syntenin. J. Biol. Chem., 275, 19933-19941.
7. Harris, B.Z. & Lim, W.A. (2001) Mechanism and role of PDZ domains in signalling complex assembly. J. Cell Sci., 114, 3219-3231.
8. Muhlhahn, P. et al. (1998) Structure of interleukin-16 resembles a PDZ domain with an occluded peptide binding site. Nature Struct. Biol., 5, 682-686.
9. +T cells by IL-16 and IL-2. J. Immunol., 160, 2115-2120.
10. Schultz, J., Milpetz, F., Bork, P. & Ponting, C.P. (1998) SMART, a simple modular architecture research tool: identification of signalling domains. Proc. Natl Acad. Sci. USA, 95, 5857-5864.
11. Sciaky, D., Brazer, W., Center, D.M., Cruikshank, W.W. & Smith, T.J. (2000) Cultured human fibroblasts express constitutive IL-16 mRNA: cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism. J. Immunol., 164, 3806-3814.
12. Sharma, V., Sparks, J.L. & Vail, J.D. (2000) Human B-cell lines constitutively express and secrete interleukin-16. Immunology, 99, 266-271.
13. Sheng, M. & Sala, C. (2001) PDZ domains and the organization of supramolecular complexes. Annu. Rev. Neurosci., 24, 1-29.
14. Szabo, P., Zhao, K., Kirman, I., Le Maoult, J., Dyall, R., Cruikshank, W. & Weksler, M.E. (1998) Maturation of B cell precursors is impaired in thymic-deprived nude and old mice. J. Immunol., 161, 2248-2253.
15. Thomas, M.K., Yao, K.M., Tenser, M.S., Wong, G.G. & Habener, J.F. (1999) Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol. Cell. Biol., 19, 8492-8504.
16. Zhang, Q., Fan, J.S. & Zhang, M. (2001) Interdomain chaperoning between PSD-95, Dlg, and Zo-1 (PDZ) domains of glutamate receptor-interacting proteins. J. Biol. Chem., 276, 43216-43220.
17. Zhang, Y., Center, D.M., Wu, D.M., Cruikshank, W.W., Yuan, J., Andrews, D.W. & Kornfeld, H. (1998) Processing and activation of pro-interleukin-16 by caspase-3. J. Biol. Chem., 273, 1144-1149.
18. Zhang, Y., Kornfeld, H., Cruikshank, W.W., Kim, S., Reardon, C.C. & Center, D.M. (2001) Nuclear translocation of the N-terminal prodomain of interleukin-16. J. Biol. Chem., 276, 1299-1303.