A real-time method to evaluate the nasal deposition and clearance of acetone in the human volunteer

Inhalation Toxicology

Volumn 15, Issue 6, 2003, Pages 523-538

  Thrall, Karla D ^a   Schwartz, Ronald E ^b   Weitz, Karl K ^a   Soelberg, Jolen J ^a   Foureman, Gary L ^c   Prah, James D ^d   Timchalk, Charles ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b Otolaryngol Head and Neck Surgery   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE;

ADULT; AIR POLLUTANT; AIR SAMPLING; ARTICLE; BIOACCUMULATION; BREATH ANALYSIS; BREATHING; CLEARANCE; DYNAMICS; EVALUATION; EXHALATION; EXPOSURE; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETER; MATHEMATICAL MODEL; MONITORING; NASOPHARYNX; NORMAL HUMAN; NOSE; PLETHYSMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TECHNIQUE; VALIDATION PROCESS;

ACETONE; ADMINISTRATION, INHALATION; BREATH TESTS; CHROMATOGRAPHY, GAS; EQUIPMENT DESIGN; HUMANS; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; NASAL MUCOSA;

EID: 0037764012     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370304470     Document Type: Article

References (21)

1. Andersen, M. E., and Sarangapani, R. 2001. Physiologically based clearance/extraction models for compounds metabolized in the nose: An example with methyl methacrylate. Inhal. Toxicol. 13:397-414.
2. Bogdanffy, M. S., Sarangapani, R., Plowchalk, D. R., Jarabek, A., and Andersen, M. E. 1999. A biologically-based risk assessment for vinyl acetate-induced cancer and non-cancer inhalation toxicity. Toxicol. Sci. 51:19-35.
3. Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. 1998. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152:211-231.
4. Frederick, C. B., Gentry, P. R., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. 2001. A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure. Inhal. Toxicol. 13:359-376.
5. Gordon, S. M., Wallace, L. A., Callahan, P. J., Kenny, D. V., and Brinkman, M. C. 1998. Effect of water temperature on dermal exposure to chloroform. Environ. Health Perspect. 106:337-345.
6. Hytönen, M. L., Sala, E. L., Malmberg, H. O., and Nordman, H. 1996. Acoustic rhinometry in the diagnosis of occupational rhinitis. Am. J. Rhinology 10:393-397.
7. Johanson, G. 1991. Modelling of respiratory exchange of polar solvent. Ann. Occup. Hyg. 35:323-339.
8. Kimbell, J. S., Godo, M. N., Gross, E. A., Joyner, D. R., Richardson, R. B., and Morgan, K. T. 1997. Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol. Appl. Pharmacol. 145:388-398.
9. Landahl, H. D., and Herrmann, R. G. 1950. Retention of vapors and gases in the human nose and lung. Arch. Ind. Hyg. Occup. Med. 1:36-45.
10. Morris, J. B. 1990. First-pass metabolism of inspired ethyl acetate in the upper respiratory tracts of the F344 rat and Syrian hamster. Toxicol. Appl. Pharmacol. 102:331-445.
11. Morris, J. B. 1993. Upper respiratory tract metabolism of inspired alcohol dehydrogenase and mixed function oxidase substrate vapors under defined airflow conditions. Inhal. Toxicol. 5:203-221.
12. Morris, J. B. 1999. A method for measuring upper respiratory tract vapor uptake and its applicability to quantitative inhalation risk assessment. Inhal. Toxicol. 11:101-123.
13. Morris, J. B. 2001. Overview of upper respiratory tract vapor uptake studies. Inhal. Toxicol. 13:335-345.
14. Morris, J. B., Clay, R. J., and Cavanagh, D. G. 1986. Species differences in upper respiratory tract deposition of acetone and ethanol vapors. Fundam. Appl. Toxicol. 7:671-680.
15. Morris, J. B., Hassett, D. N., and Blanchard, K. T. 1993. A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors. Toxicol. Appl. Pharmacol. 123: 190-129.
16. Schrikker, A. C. M., de Vries, W. R., Zwart, A., and Luijendijk, S. C. M. 1985. Uptake of highly soluble gases in the epithelium of the conducting airways. Pflugers Arch. 405:389-394.
17. Snipes, M. D., Spoo, J. W., Brookins, L. K., Jones, S. E., Mauderly, J. L., Orwat, T. B., Stiver, J. H., and Dahl, A. R. 1991. A method for measuring nasal and lung uptake of inhaled vapor. Fundam. Appl. Toxicol. 16:81-91.
18. Thrall, K. D., Poet, T. S., and Corley, R. A. 1999. An innovative method to determine percutaneous absorption: Real-time breath analysis and physiologically based pharmacokinetic modeling. In Percutaneous absorption, eds. R. L. Bronaugh and H. I. Maibach, pp. 929-937. New York: Marcel Dekker.
19. Thrall, K. D., Weitz, K. K., and Woodstock, A. D. 2002. Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteers. Toxicol. Sci. 68:280-287.
20. U.S. Environmental Protection Agency. 1994. Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry. EPA/600/8-90-066F. Washington, DC: U.S. EPA.
21. Wigaeus, E., Holm, S., and Åstrand, I. 1981. Exposure to acetone: Uptake and elimination in man. Scand. J. Work Environ. Health 7:84-94.