The pathogenesis of giant cell arteritis

Bulletin on the Rheumatic Diseases

Volumn 51, Issue 8, 2002, Pages

  Weyand, Cornelia M ^a   Goronzy, Jörg J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOGENIC FACTOR; C REACTIVE PROTEIN; CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

ADJUVANT THERAPY; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; CORTICOSTEROID THERAPY; ERYTHROCYTE SEDIMENTATION RATE; ERYTHROPOIESIS; GIANT CELL ARTERITIS; GRANULOMA; HUMAN; HYPERPLASIA; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOPATHOLOGY; INFLAMMATION; ISCHEMIA; MACROPHAGE; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; RHEUMATIC POLYMYALGIA; T LYMPHOCYTE ACTIVATION; TISSUE INJURY;

EID: 0037742744     PISSN: 00075248     EISSN: 00075248     Source Type: Journal    
DOI: None     Document Type: Review

References (32)

1. Weyand CM, Goronzy JJ. Pathogenic principles in giant cell arteritis. Int J Cardiol 2000;75:S9-S15.
2. Weyand CM. The Dunlop-Dottridge Lecture: The pathogenesis of giant cell arteritis. J Rheumatol 2000;27:517-22.
3. Ghanchi FD, Dutton GN. Current concepts in giant cell (temporal) arteritis. Surv Ophthalmol 1997;42:99-123.
4. Brack A, Martinez-Taboada V, Stanson A, Goronzy JJ, Weyand CM. Disease pattern in cranial and largevessel giant cell arteritis. Arthritis Rheum 1999;42:311-7.
5. Nordborg E. Epidemiology of biopsy-positive giant cell arteritis: an overview. Clin Exp Rheumatol 2000;18:S15-S17.
6. Hayreh SS. Ischaemic optic neuropathy. Indian J Ophthalmol 2000;48:171-94.
7. Bhatti MT, Tabandeh H. Giant cell arteritis: diagnosis and management. Curr Opin Ophthalmol 2001;12:393-9.
8. Weyand CM. Vasculitis: A dialogue between the artery and the immune system. In Hoffman GS, Weyand CM (eds). Inflammatory Diseases of Blood Vessels. New York: Marcel Dekker, Inc., 2002. pp. 1-12.
9. Weyand CM, Goronzy JJ. Giant cell arteritis: Pathogenesis. In Hoffman GS, Weyand CM (eds). Inflammatory Diseases of Blood Vessels. New York: Marcel Dekker, Inc., 2002. pp. 413-424.
10. Kaiser M, Weyand CM, Bjornsson J, Goronzy JJ. Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis. Arthritis Rheum 1998;41:623-33.
11. Cid MC, Grant DS, Hoffman GS, Auerbach R, Fauci AS, Kleinman HK. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J Clin Invest 1993;91:977-85.
12. Kaiser M, Younge B, Bjornsson J, Goronzy JJ, Weyand CM. Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Am J Pathol 1999;155:765-74.
13. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Ann Intern Med 1994;121:484-91.
14. Weyand CM, Tetzlaff N, Bjornsson J, Brack A, Younge B, Goronzy JJ. Disease patterns and tissue cytokine profiles in giant cell arteritis. Arthritis Rheum 1997;40:19-26.
15. Weyand CM, Goronzy JJ. Arterial wall injury in giant cell arteritis. Arthritis Rheum 1999;42:844-53.
16. Nordborg C, Nordborg E, Petursdottir V. The pathogenesis of giant cell arteritis: morphological aspects. Clin Exp Rheumatol 2000;18:S18-S21.
17. Rittner HL, Kaiser M, Brack A, Szweda LI, Goronzy JJ, Weyand CM. Tissue-destructive macrophages in giant cell arteritis. Circ Res 1999;84:1050-8.
18. Nikkari ST, Hoyhtya M, Isola J, Nikkari T. Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am J Pathol 1996; 149:1427-33.
19. Rittner HL, Hafner V, Klimiuk PA, Szweda LI, Goronzy JJ, Weyand CM. Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. J Clin Invest 1999;103:1007-13.
20. Borkowski, A, Younge BR, Szweda LI, Mock B, Bjornsson J, Moeller K, Goronzy JJ, Weyand CM. Reactive nitrogen intermediates in giant cell arteritis: selective targeting of neocapillaries. Am J Pathol 2002; In press.
21. Martinez-Taboada V, Brack A, Hunder GG, Goronzy JJ, Weyand CM. The inflammatory infiltrate in giant cell arteritis selects against B lymphocytes. J Rheumatol 1996;23:1011-4.
22. Wagner AD, Bjornsson J, Bartley GB, Goronzy JJ, Weyand CM. Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology. Am J Pathol 1996;148:1925-33.
23. Weyand CM, Schonberger J, Oppitz U, Hunder NN, Hicok KC, Goronzy JJ. Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes. J Exp Med 1994;179:951-60.
24. Martinez-Taboada V, Hunder NN, Hunder GG, Weyand CM, Goronzy JJ. Recognition of tissue residing antigen by T cells in vasculitic lesions of giant cell arteritis. J Mol Med 1996;74:695-703.
25. Wagner AD, Goronzy JJ, Weyand CM. Functional profile of tissue-infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease. J Clin Invest 1994;94:1134-40.
26. Roche NE, Fulbright JW, Wagner AD, Hunder GG, Goronzy JJ, Weyand CM. Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum 1993;36:1286-94.
27. Weyand CM, Fulbright JW, Hunder GG, Evans JM, Goronzy JJ. Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity. Arthritis Rheum 2000;43:1041-8.
28. Hazleman B. Laboratory investigations useful in the evaluation of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). Clin Exp Rheumatol 2000;18:S29-S31.
29. Uddhammar AC. Von Willebrand factor in polymyalgia rheumatica and giant cell arteritis. Clin Exp Rheumatol 2000;18:S32-S33.
30. Weyand CM, Fulbright JW, Evans JM, Hunder GG, Goronzy JJ. Corticosteroid requirements in polymyalgia rheumatica. Arch Intern Med 1999;159:577-84.
31. Brack A, Rittner HL, Younge BR, Kaltschmidt C, Weyand CM, Goronzy JJ. Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. J Clin Invest 1997;99:2842-50.
32. Weyand CM, Kaiser M, Yang H, Younge B, Goronzy JJ. Therapeutic effects of acetylsalicylic acid in giant cell arteritis. Arthritis Rheum 2002;46:457-66.