Estrogen increases inducible nitric oxide synthase gene expression

American Journal of Obstetrics and Gynecology

Volumn 188, Issue 5, 2003, Pages 1208-1210

  Walsh, Leigh S ^a   Ollendorff, Arthur ^a   Mershon, John L ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Estrogen; Inflammation; Nitric oxide synthase

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; GAMMA INTERFERON; LUCIFERASE;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR SYSTEM; CELL STRAIN COS1; CONTROLLED STUDY; FUSION GENE; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INFLAMMATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPORTER GENE;

EID: 0037719970     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2003.350     Document Type: Article

References (18)

1. Barrett-Connor E, Grady D. Hormone replacement therapy, heart disease, and other considerations. Annu Rev Public Health 1998;19:55-72.
2. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, et al. Post menopausal estrogen therapy and cardiovascular disease: ten year follow-up from the nurse's health study. N Engl J Med 1991;325:756-62.
3. Mendelsohn ME. Mechanisms of estrogen action in the cardiovascular system. J Steroid Biochem Mol Biol 2000;74:337-43.
4. Mosca L, Collins P, Herrington DM, Mendelsohn ME, Pasternak RC, Robertson RM, et al. Hormone replacement therapy and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 2001;104:499-503.
5. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 2002;288:49-57.
6. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002;288:321-33.
7. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
8. Herrington DM, Brosnihan KB, Pusser BE, Seely EW, Ridker PM, Rifai N, et al. Differential effects of E and droloxifene on C-reactive protein and other markers of inflammation in healthy postmenopausal women. J Clin Endocrinol Metab 2001;86:4216-22.
9. Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? what does it mean? Circ Res 2000;87:956-60.
10. Darkow DJ, Lu L, White RE. Estrogen relaxation of coronary, artery smooth muscle is mediated by nitric oxide and cGMP. Am J Physiol 1997;272:H2765-73.
11. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett 1995;360:291-3.
12. Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Ann Rev Physiol 2002;64:749-74.
13. Nathan C, Xie Q-W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-8.
14. Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002;295:505-8.
15. Binko J, Majewski H. 17Beta-estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS. Am J Physiol 1998;274:H853-9.
16. Tamura K, Yamaguchi K, Kogo H. 17Beta-estradiol inhibits ovariectomy-induced expression of inducible nitric oxide synthase in rat aorta in vivo. Life Sci 2000;66:PL259-64.
17. de Vera ME, Shapiro RA, Nussler AK, Mudgett JS, Simmons RL, Morris SM Jr, et al. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci U S A 1996;93:1054-9.
18. Herrington DM, Reboussin DM, Brosnihan KB, Sharp PC, Shumaker SA, Snyder TE, et al. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Engl J Med 2000;343:522-9.