The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the β-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid

Organic and Biomolecular Chemistry

Volumn 1, Issue 4, 2003, Pages 684-691

  Aggarwal, Varinder K ^a   Roseblade, Stephen ^a   Alexander, Rikki ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; HYDROLYSIS; MOLECULAR DYNAMICS; ORGANIC ACIDS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

AMNO ACID; CISPENTACIN; DIASTEREOSELECTIVE CYCLOADDITIONS; DISTEREOMER; DITHIOACETAL BISSULFOXIDES; INTRAMOLECULAR NITRONE CYCLOADDITIONS; KETENE;

SULFUR COMPOUNDS;

2 AMINOCYCLOPENTANECARBOXYLIC ACID; 4 AMINO PYRROLIDINE 3 CARBOXYLIC ACID; 4-AMINO-PYRROLIDINE-3-CARBOXYLIC ACID; ANTIFUNGAL AGENT; CARBOXYLIC ACID; CYCLOLEUCINE; DRUG DERIVATIVE; NITROGEN OXIDE; NITRONES; PYRROLIDINE DERIVATIVE; SULFOXIDE;

ARTICLE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

ANTIFUNGAL AGENTS; CARBOXYLIC ACIDS; CYCLOLEUCINE; NITROGEN OXIDES; PYRROLIDINES; STEREOISOMERISM; SULFOXIDES;

EID: 0037712376     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b212719a     Document Type: Article

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