Performance of a corticosteroid inhaler with a spacer fashioned from a plastic cold-drink bottle: Effects of changing bottle volume

Journal of Asthma

Volumn 40, Issue 3, 2003, Pages 237-242

  Taylor, Stacy Amburgy ^a   Asmus, Michael J ^b   Liang, Judy ^b   Coowanitwong, Intira ^b   Vafadari, Ramin ^b   Hochhaus, Günther ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE PROPIONATE; POLYETHYLENE TEREPHTHALATE;

AEROSOL; ASTHMA; COMPARATIVE STUDY; CONFERENCE PAPER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; METERED DOSE INHALER; OROPHARYNX; PARTICLE SIZE; TREATMENT OUTCOME;

ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; EQUIPMENT DESIGN; HUMANS; INHALATION SPACERS; METERED DOSE INHALERS; OROPHARYNX; POLYETHYLENE TEREPHTHALATES;

EID: 0037709945     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.1081/JAS-120018712     Document Type: Conference Paper

References (33)

1. National Asthma Education and Prevention Program. Expert Panel Report 2. Pharmacologic therapy: The medications. In: Guidelines for the Diagnosis and Management of Asthma. US Department of Health and Human Services, National Institutes of Health, NIH Publication # 97-4051, 1997:59.
2. Amirav I, Newhouse MT. Metered dose inhaler accessory devices in acute asthma: efficacy and comparison with nebulisers: a literature review. Arch Pediatr Adolesc Med 1997; 151:876-882.
3. Epstein SW, Manning CP, Ashley MJ, Corey PN. Survey of the clinical use of pressurized aerosol inhalers. Can Med Assoc J 1979; 120:813-816.
4. Coady TJ, Stewart CJ, Davies HJ. Synchronization of bronchodilator release. Practitioner 1976; 217:273-275.
5. Crompton GK. Problems patients have using pressurized aerosol inhalers. Eur J Respir Dis 1982; 63(suppl 119):101-104.
6. Appel D. Faulty use of canister nebulizers for asthma. J Fam Pract 1982; 14:1135-1139.
7. Chryssidis E, Frewin D, Frith P. Compliance with aerosol therapy in chronic obstructive lung disease. NZ Med J 1981; 94:375-377.
8. Paterson I, Crompton G. Use of pressurized aerosols by asthmatic patients. Br Med J 1976; 1:76-77.
9. Self TH, Brooks JB, Lieberman P, Ryan MR. The value of demonstration and role of the pharmacist in teaching the correct use of pressurized bronchodilators. Can Med Assoc J 1983; 128:129-131.
10. Salzman GA, Pyszczynski DR. Oropharyngeal candidasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with AeroChamber. J Allergy Clin Immunol 1988; 81:424-428.
11. Konig P. Spacer devices used with metered-dose inhalers. Breakthrough or gimmick? Chest 1985; 88:276-284.
12. Ahrens R, Lux C, Bahl T, Han SH. Choosing the metered-dose inhaler spacer or holding chamber that matches the patient's need: evidence that the specific drug being delivered is an important consideration. J Allergy Clin Immunol 1995; 96(2):288-294.
13. Barry PW, O'Callaghan C. The output of budesonide from spacer devices assessed under simulated breathing conditions. J Allergy Clin Immunol 1999; 104:1205-1210.
14. Barry PW, O'Callaghan C. A comparative analysis of the particle size output of beclomethasone dipropionate, salmeterol xinafoate and fluticasone propionate metered dose inhalers used with the babyhaler, volumatic and aerochamber spacer devices. Br J Clin Pharmacol 1999; 47:357-360.
15. Dalby RN, Somaraju S, Chavan VS, Jarvis D. Evaluation of aerosol drug output from the OptiChamber and AeroChamber spacers in a model system. J Asthma 1998; 35:173-177.
16. Sritara P, Janvitayanuchit S. Improvement of inhaler efficacy by home-made spacer. J Med Assoc Thai 1993 Dec; 76(12):693-697.
17. Zar HJ, Asmus MJ, Weinberg EG. A 500 mL plastic bottle - an effective inhalant spacer for children with asthma. Pediatric Allergy and Immunology 2002; 13. in-press.
18. Zar HJ, Brown G, Donson H, Brathwaite N, Mann MD, Weinberg EG. Home-made spacers for bronchodilator therapy in children with acute asthma: a randomized trial. Lancet 1999 Sep 18; 354(9183):979-982.
19. Singhal T, Garg H, Arora HS, Lodha R, Pandey RM, Kabra SK. Efficacy of a home-made spacer with acute exacerbation of bronchial asthma: a randomized controlled trial. Indian J Pediatr 2001 Jan; 68(1):37-40.
20. Zar HJ, Liebenberg M, Weinberg EG, Binns HJ, Mann MD. The efficacy of alternative spacer devices for delivery of aerosol therapy to children with asthma. Ann Trop Paediatr 1998 Jun; 18(2):75-79.
21. Barry PW, O'Callaghan C. Optimum length and width for a spacer device. Pharm Pharmacol Comm 2000; 6:1-5.
22. Teo J, Kwang L W, Yip WCL. An inexpensive spacer for use with metered-dose bronchodilators in young asthmatic children. Pediatr Pulmonol 1988; 5:244-246.
23. Wong C, Ayson M, Rajasingham S, Burgess C, Crane J. Efficacy of a simple DIY spacer with a metered dose inhaler in asthma. New Z Med J 1995; 256-257.
24. Zar HJ, Green C, Mann MD, Weinberg EG. A novel method for constructing an alternative spacer for patients with asthma. S Afr Med J 1999; 89:1-4.
25. Pierart F, Wildhaber JH, Vrancken I, Devadason SG, Le-Souef PN. Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery. Eur Respir J 1999; 13:673-678.
26. The United States Pharmacopeial Convention. Physical tests and determinations, aerosols. In: The Pharmacopeia of the United States of America. 24th ed. Rockville, MD: USP Convention, 2000:1895-1912.
27. Phelan RF, Cuddihy RG, Fisher GL, Moss OR, Schlesinger RD, Swift DL, Yeh HC. Main features of the proposed NCRP respiratory tract model. Rad Prot Dos 1991; 38:179-184.
28. Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Physics 1966; 12:173-208.
29. Asmus MJ, Liang J, Coowanitwong I, Vafadari R, Hochhaus G. In-vitro deposition of fluticasone aerosol from a metered-dose inhaler with and without two common valved holding chambers. Ann Allergy Asthma Immunol 2002; 88:204-208.
30. Toogood JH, Baskerville J, Jennings B, Lefcoe NM, Johansson SA. Use of spacers to facilitate inhaled corticosteroid treatment of asthma. Am Rev Respir Dis 1984; 129:723-729.
31. Newman SP, Pitcairn GR, Adkin DA, Vidgren MT, Silvasti M. Comparison of beclomethasone dipropionate delivery by easyhaler dry powder inhaler and MDI plus large volume spacer. J Aerosol Med 2001; 14:217-225.
32. Smith KJ, Chan HK, Brown KF. Influence of flow rate on aerosol particle size distributions from pressurized and breath-actuated inhalers. J Aerosol Med 1998; 11:231-245.
33. Davies N, Feddah M, Brown K, Gipps E. In-vitro characterization of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates. J Pharm Sci 2000; 3:318-324.