Comparison of beclomethasone dipropionate delivery by Easyhaler® dry powder inhaler and pMDI plus large volume spacer

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 14, Issue 2, 2001, Pages 217-225

  Newman, S P ^a   Pitcairn, G R ^a   Adkin, D A ^a   Vidgren, M T ^b   Silvasti, M ^c  

^a PHARMACEUTICAL PROFILES LTD   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c ORION CORPORATION   (Finland)

Author keywords

Beclomethasone dipropionate; Easyhaler ; Lung deposition; pMDI; Volumatic spacer

Indexed keywords

BECLOMETASONE DIPROPIONATE; TECHNETIUM 99M;

ADULT; AEROSOL; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEVICE; DRUG DELIVERY SYSTEM; DRY POWDER; FEMALE; GAMMA SCINTIGRAPHY; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; LUNG; MALE; METERED DOSE INHALER; NORMAL HUMAN; OROPHARYNX; POWDER INHALER; RANDOMIZED CONTROLLED TRIAL; SURFACE CHARGE;

EID: 0034884267     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/08942680152484144     Document Type: Article

References (29)

1. Medical aerosol inhalers: Past, present and future
2. High dose nebulized steroid in the treatment of chronic steroid-dependent asthma
3. New propellant-free technologies under investigation
4. Effect of add-on devices for aerosol drug delivery: Deposition studies and clinical aspects
5. Chlorofluorocarbon-free inhalers: Are we ready for the change?
6. Easyhaler multiple dose powder inhaler - Practical and effective alternative to the pressurized MDI
7. Equivalence of two steroid-containing inhalers: Easyhaler multidose powder inhaler compared with conventional aerosol with large volume spacer
8. A new beclomethasone dipropionate multidose powder inhaler in the treatment of bronchial asthma
9. Lung volumes and forced ventilatory flows
10. Improved targeting of beclomethasone dipropionate (250 μg metered dose inhaler) to the lungs of asthmatics with the Spacehaler
11. Pulmonary drug delivery from the Taifun dry powder inhaler is relatively independent of the patient's respiratory effort
12. Assessing lung deposition of inhaled medications
13. The effect of handling techniques on electrostatic charge on spacer devices: A correlation with in vitro particle size analysis
14. Washington plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery
15. Pressurised aerosol deposition in the human lung with and without an "open" spacer
16. Tissue attenuation corrections in gamma scintigraphy
17. Imaging techniques for assessing drug delivery in man
18. Comparison of gamma scintigraphy and a pharmacokinetic technique for assessing pulmonary deposition of terbutaline sulphate delivered by pressurized metered dose inhaler
19. 99mTc-labelled particles in healthy volunteers after inhalation from a metered dose inhaler and from a novel multiple-dose powder inhaler
20. 99mTc labelled salbutamol delivered from a novel multiple dose powder inhaler
21. Scintigraphic assessment of drug delivery from the Ultrahaler dry powder inhaler
22. Lung deposition patterns of directly labelled salbutamol in normal subjects and in patients with reversible airways obstruction
23. Inhalation delivery of asthma drugs
24. The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients
25. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
26. Efficacy and safety of inhaled corticosteroids: New developments
27. Use of spacers to facilitate inhaled corticosteroid treatment in asthma
28. Lack of systemic effects as assessed by serum cortisol AUC of beclomethasone dipropionate at 800 μg daily dose inhaled via Easyhaler
29. Clinical evaluation of a new demand-inhalation MDI aerosol delivery device