Human cervix contains functional luteinizing hormone/human chorionic gonadotropin receptors

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 7, 2003, Pages 3409-3414

  Lin, P C ^a,b   Li, X ^a   Lei, Z M ^a   Rao, Ch V ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; CYCLIC AMP; CYCLOOXYGENASE 2; LUTEINIZING HORMONE RECEPTOR;

ARTICLE; COLUMNAR EPITHELIUM; CONTROLLED STUDY; FEMALE; FUNCTIONAL ANATOMY; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DENSITY; UTERINE CERVIX; UTERINE ENDOCERVIX; WESTERN BLOTTING;

CERVIX UTERI; CYCLIC AMP; CYCLOOXYGENASE 2; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, LH; RNA, MESSENGER;

FALLOPIA;

EID: 0037700609     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021966     Document Type: Article

References (50)

1. Pierce JG, Parsons TF 1981 Glycoprotein hormones: structure and function. Annu Rev Biochem 50:466-495
2. McFarland KC, Sprengel R, Phillips HS, Kohler M, Rosemblit N, Nikolics K, Segaloff DL, Seeburg PH 1989 Lutropin-choriogonadotropin receptor: an unusual member of the G-protein-coupled receptor family. Science 245: 494-499
3. Loosfelt H, Misrahi M, Atger M, Salesse R, Thi MTVH, Jolivet A, Guichon-Mantel A, Sar S, Jallal B, Garnier J, Migrom E 1989 Cloning and sequencing of porcine LH/hCG receptor cDNA: variants lacking transmembrane domain. Science 245:525-528
4. Reshef E, Lei ZM, Rao ChV, Pridham DD, Chegini N, Luborsky JL 1990 The presence of gonadotropin receptors in non-pregnant human uterus, human placenta, fetal membranes and decidua. J Clin Endocrinol Metab 70:421-430
5. Lei ZM, Reshef E, Rao ChV 1992 The expression of human chorionic gonadotropin/luteinizing hormone receptors in human endometrial blood vessels. J Clin Endocrinol Metab 75:651-659
6. Lei ZM, Toth P, Ran ChV, Pridham D 1993 Novel co-expression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors and their ligand, hCG, in human fallopian tubes. J Clin Endocrinol Metab 77: 863-872
7. Bhattacharya S, Banerjee J, Sen S, Manna PR 1993 Human chorionic gonadotropin binding sites in the human endometrium. Acta Endocrinol 129:15-19
8. Bernardini L, Moretti-Rojas I, Brush M, Rojas FJ, Balmaceda JP 1995 Status of hCG/LH receptor and G-proteins in human endometrium during artificial cycles of hormone replacement therapy. J Soc Gynecol Invest 2:630-635
9. Rao ChV 2001 An overview of the past, present and future of nongonadal LH/hCG actions in reproductive biology and medicine. Semin Reprod Med 19:7-17
10. Tang B, Gurpide E 1993 Direct effect of gonadotropins on decidualization of human endometrial stromal cells. J Steroid Biochem Mol Biol 47:115-121
11. Toth P, Li X, Rao ChV, Lincoln SR, Sanfilippo JS, Spinnato JA, Yussman MA 1994 Expression of functional human chorionic gonadotropin/human luteinizing hormone receptor gene in human uterine arteries. J Clin Endocrinol Metab 79:307-315
12. Han SW, Lei ZM, Rao ChV 1996 Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into decidua. Endocrinology 137:1791-1797
13. Han, SW, Lei ZM, Rao ChV 1996 Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin in mucosal cells from human fallopian tubes. Endocrinology 137:2929-2937
14. Sun T, Lei ZM, Rao ChV 1997 A novel regulation of the oviductal glycoprotein gene expression by luteinizing hormone in bovine tubal epithelial cells. Mol Cell Endocrinol 131:97-108
15. Han SW, Lei ZM, Rao ChV 1999 Treatment of human endometrial stromal cells with chorionic gonadotropin induces their morphological and functional differentiation into decidua. Mol Cell Endocrinol 147:7-16
16. Zhou XL, Lei ZM, Rao ChV 1999 Treatment of human endometrial gland epithelial cells with chorionic gonadotropin/luteinizing hormone increases the expression of cyclooxygenase-2 gene. J Clin Endocrinol Metab 84:3364-3377
17. Uzumcu M, Coskun S, Jaroudi K, Hollanders JMG 2000 Effect of human chorionic gonadotropin on cytokine production from human endometrial cells in vitro. Am J Reprod Immunol 40:83-88
18. Fanchin R, Peltier E, Frydman R, deZiegler D 2001 Human chorionic gonadotropin: does it affect human endometrial morphology in vivo. Semin Reprod Med 19:31-36
19. Toth P 2001 Clinical data supporting importance of vascular LH/hCG receptors of uterine blood vessels. Semin Reprod Med 19:55-62
20. Licht P, Russu V, Lehmeyer S, Moll J, Siebzehnrubl E, Wildt L 2002 Intra-uterine microdialysis reveals cycle-dependent regulation of endometrial insulin-like growth factor binding protein-1 secretion by human chorionic gonadotropin. Fertil Steril 78:252-258
21. Zygmunt M, Herr F, Keller-Schoenwetter S, Kunz-Rpp M, Munstedt K, Rao ChV, Lang U, Preissner KT 2002 Characterization of human chorionic gonadotropin as an angiogenic factor. J Clin Endocrinol Metab 87:5290-5296
22. Mishra S, Lei ZM, Rao ChV 2003 A novel role of luteinizing hormone in embryo development in cocultures. Biol Reprod 68:1455-1462
23. Kornyei J, Lei ZM, Rao ChV 1993 Human myometrial smooth muscle cells are novel targets of direct regulation by human chorionic gonadotropin. Biol Reprod 49:1149-1157
24. Eta E, Ambrus G, Rao ChV 1994 Direct regulation of human myometrial contractions by human chorionic gonadotropin. J Clin Endocrinol Metab 79: 1582-1586
25. Ambrus G, Rao ChV 1994 Novel regulation of pregnant human myometrial smooth muscle cell gap junctions by human chorionic gonadotropin. Endocrinology 135:2772-2779
26. Chatterjee A, Jana NR, Bhattacharya S 1997 Stimulation of cyclic AMP, 17 β-oestradiol and protein synthesis by human chorionic gonadotrophin in human endometrial cells. Hum Reprod 12:1903-1908
27. Horiuchi A, Nikaido T, Yoshizawa T, Itoh K, Kobayashi Y, Toki T, Konishi K, Fujii S 2000 Human chorionic gonadotropin promotes proliferation of uterine leiomyomal cells greater than that of myometrial smooth muscle cells in vitro. Mol Hum Reprod 6:523-528
28. Zuo J, Lei ZM, Rao ChV 1994 Human myometrial chorionic gonadotropin/luteinizing hormone receptors in preterm and term deliveries. J Clin Endocrinol Metab 79:907-911
29. Than NG, Itakura A, Rao ChV, Nohira T, Toth P, Mansell JP, Isaka K, Nishi H, Takayama M, Than GN 2003 Clinical applications of pregnancy-related proteins: a workshop report. Trophoblast Res 17:S60-S64
30. Danforth DN, Veis A, Breen M, Weinstein HG, Buckingham JC, Manalo P 1974 The effect of pregnancy and labor on the human cervix. Changes in collagen, glycoproteins and glycosaminoglycans. Am J Obstet Gynecol 120: 641-650
31. Liggins GC 1983 The forces of labor: uterine contractions and the resistance of the cervix. Clin Obstet Gynecol 26:1-3
32. Uldbjerg N, Forman A, Petersen L, Skajaa K, Svane D 1992 Biochemical changes of the uterus and cervix during pregnancy. In: Reece EA, Hobbins JC, Mahoney MJ, Petrie RH, eds. Medicine of the fetus and mother. Philadelphia: JB Lippincott Co.; 849-868
33. Leppert PC 1998 The biochemistry and physiology of the uterine cervix during gestation and parturition. Prenat Neonat Med 3:103-105
34. Ludmir J, Sehdev HM 2000 Anatomy and physiology of the uterine cervix. Clin Obstet Gynecol 43:433-439
35. Wallis, RM, Hiller K 1981 Regulation of collagen dissolution in human cervix by oestradiol-17β and progesterone. J Reprod Fertil 62:55-61
36. Gorodeski GI, Eckert RL, Utian WH, Rorke EA 1990 Maintenance of in vivo-like keratin expression, sex steroid responsiveness, and estrogen receptor expression in cultured human ectocervical epithelial cells. Endocrinology 126: 399-406
37. Sato T, Ito A, Mori Y, Yamashita K, Hayakawa T, Nagase H 1991 Hormonal regulation of collagenolysis in uterine cervical fibroblasts. Modulation of synthesis of procollagenase, prostromelysin and tissue inhibitor metalloproteinases (TIMP) by progesterone and oestradiol 17β. Biochem J 275:645-650
38. Barclay CG, Brennad JE, Kelly RW, Calder AA 1993 Interleukin-8 production by human cervix. Am J Obstet Gynecol 169:625-632
39. Osmers R, Blaser J, Kuhn W, Tshesche H 1995 Interleukin-8 synthesis and the onset of labor. Obstet Gynecol 86:223-229
40. Thompson AJ, Lunan CB, Cameron AD, Cameron IT, Greet IA, Norman JE 1997 Nitric oxide donors induce ripening of the human uterine cervix: a randomized controlled trial. Br J Obstet Gynaecol 104:1054-1057
41. Tschugguel W, Schneeberger C, Lass H, Stonek F, Zaghlula MB, Czerwenka K, Schatten C, Kaider A, Husslein P, Huber JC 1999 Human cervical ripening is associated with an increase in cervical inductive nitric oxide synthase expression. Biol Reprod 60:1367-1372
42. 4. Nature 227:680-685
43. Dunn, SD 1986 Effects of the modification of transfer buffer composition and the renaturation of proteins in gels on the recognition of proteins on Western blots by monoclonal antibodies. Anal Biochem 157:144-153
44. Keinanen KP, Kellokumpu S, Rajaniemi H 1987 Visualization of the rat ovarian lutropin receptor by ligand blotting. Mol Cell Endocrinol 49:33-38
45. Steel RGD, Torrie JH 1960 Principles and procedures of statistics, with special reference to the biological sciences. New York: McGraw Hill
46. Wang P, Lei ZM, Rao ChV 1998 Cyclic AMP/protein kinase A signaling in luteinizing hormone and human chorionic gona dotropin action to increase the oviductal glycoprotein synthesis in bovine tubal epithelial cells. Biol Reprod 58(Suppl 1):114 (Abstract 137)
47. 2. Prostaglandins 28:217-227
48. 2 gel for cervical ripening and induction of labor: a critical analysis. Am J Obstet Gynecol 160:529-534
49. Kurtzman JT, Spinnato JA, Goldsmith LJ, Zimmerman MJ, Klein M, Lei ZM, Rao ChV 1999 Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model. Am J Obstet Gynecol 181:853-857
50. Mizrachi D, Shemesh M 1999 Expression of functional luteinizing hormone receptor and its messenger ribonucleic acid in bovine cervix: luteinizing hormone augmentation of intracellular cyclic AMP, phosphate inositol and cyclooxygenase. Mol Cell Endocrinol 157:191-200