Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model

American Journal of Obstetrics and Gynecology

Volumn 181, Issue 4, 1999, Pages 853-857

  Kurtzman, James T ^a   Spinnato, Joseph A ^b   Goldsmith, Linda J ^b   Zimmerman, Matthew J ^b   Klem, Michelle ^b   Lei, Z M ^b   Rao, Ch V ^b  

^a University of Louisville School of Medicine   (United States)

^b NONE

Author keywords

Human chorionic gonadotropin; Labor inhibition; Mouse model; Preterm labor; Tocolysis

Indexed keywords

CARBOPROST TROMETAMOL; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT; LUTEINIZING HORMONE; PROSTAGLANDIN F2 ALPHA; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; INBRED STRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; TOCOLYSIS;

EID: 0032721679     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(99)70313-3     Document Type: Conference Paper

References (15)

1. 1. Wise PH, Wampler N, Barfield W. The importance of extreme prematurity and low birth weight to US neonatal mortality patterns: implications for prenatal care and women's health. J Am Med Womens Assoc 1995;50:152-5.
2. 2. Reshef E, Lei ZM, Rao ChV, Pridham DD, Chegini N, Luborsky JL. The presence of gonadotropin receptors in non-pregnant human uterus, human placenta, fetal membranes, and decidua. J Clin Endocrinol Metab 1990;70:421-9.
3. 3. Lei ZM, Toth P, Rao ChV, Pridham D. Novel co-expression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors, their ligand, hCG, in human fallopian tubes. J Clin Endocrinol Metab 1993;77:863-72.
4. 4. Al-Hader AA, Lei ZM, Rao ChV. Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. Biol Reprod 1997;56:501-7.
5. 5. Ambrus G, Rao ChV. Novel regulation of pregnant human myometrial smooth muscle cell gap junctions by human chorionic gonadotropin. Endocrinology 1994;135:2772-9.
6. 6. Kornyei JL, Lei ZM, Rao ChV. Human myometrial smooth muscle cells are novel targets of direct regulation by human chorionic gonadotropin. Biol Reprod 1993;49:1149-57.
7. 7. Zuo J, Lei ZM, Rao ChV. Human myometrial chorionic gonadotropin/luteinizing hormone receptors in preterm and term deliveries. J Clin Endocrinol Metab 1994;79:907-11.
8. 8. Eta E, Ambrus G, Rao ChV. Direct regulation of human myometrial contractions by human chorionic gonadotropin. J Clin Endocrinol Metab 1994;79:1582-6.
9. 9. Toth P, Gimes G, Paulin F, Rao ChV. hCG treatment in early gestation: its impact on uterine blood flow and pregnancy outcome [abstract]. Fertil Steril 1998;70:S46.
10. 10. Toppozada MK. Does hCG have a direct effect on the human myometrium? [abstract]. Fertil Steril 1998;70:S68.
11. 11. Zuo J, Lei ZM, Rao ChV, Pietrantoni M, Cook VD. Differential cyclooxygenase-1 and -2 gene expression in human myometria from preterm and term deliveries. J Clin Endocrinol Metab 1994;79:894-9.
12. 2 receptor gene in human uterus. Biol Reprod 1992;47:105-17.
13. 13. Toth P, Li X, Rao ChV, Lincoln SR, Sanfilippo JS, Spinnato JA, et al. Expression of functional human chorionic gonadotropin/human luteinizing hormone receptor gene in human uterine arteries. J Clin Endocrinol Metab 1994;79:307-15.
14. 14. Toth P, Rao ChV. Direct novel regulation of cyclooxygenase and prostacyclin synthase by human chorionic gonadotropin in the human amnion. Trophoblast Res 1994;8:503-14.
15. 15. Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Ann Rev Biochem 1981;50:465-95.