Nitric oxide donors induce ripening of the human uterine cervix: A randomised controlled trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 104, Issue 9, 1997, Pages 1054-1057

  Thomson, Andrew J ^a   Lunan, C Burnett ^a   Cameron, Alan D ^a   Cameron, Iain T ^a   Greer, Ian A ^a   Norman, Jane E ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GEMEPROST; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; NITRIC OXIDE DONOR; PROSTAGLANDIN DERIVATIVE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; INTRAVAGINAL DRUG ADMINISTRATION; PREGNANCY TERMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UTERINE CERVIX DILATATION; VACUUM ASPIRATION;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTION, INDUCED; ADMINISTRATION, INTRAVAGINAL; ADULT; ALPROSTADIL; CERVIX UTERI; FEMALE; HUMANS; ISOSORBIDE DINITRATE; NITRIC OXIDE; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROSPECTIVE STUDIES;

EID: 0030799375     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1997.tb12066.x     Document Type: Article

References (20)

1. Anggard E. Nitric oxide: mediator, murderer, and medicine. Lancet 1994; 343: 1199–1206.
2. Buhimschi I, Ali M, Jain V, Chwalisz K, Garfield R. Differential regulation of nitric oxide in the rat uterus and cervix during pregnancy and labour. Hum Reprod 1996; 11: 1755–1766.
3. Ali M, Yallampalli C, Chwalisz K, Garfield R. Changes in mRNA levels of nitric oxide synthases in rat uterus and cervix during pregnancy. J Soc Gynecollnvest 1995; 2: 80.
4. Qing S, Bier H, Garfield R, Chwalisz K. Local application of a nitric oxide (NO) donor induces cervical ripening. J Soc Gvnecol Invest 1996; 3: 462.
5. 2 pessaries to facilitate first trimester aspiration termination. Br J Obstet Gynaecol 1981; 88: 1033–1037.
6. Schultz KF, Grimes DA, Cates W. Measures to prevent cervical injury during suction curettage abortion. Lancet 1983; 1: 1182–1184.
7. Grimes DA, Schultz KF, Cates WJ. Prevention of uterine perforation during curettage abortion. JAMA 1984; 251: 2108–2111.
8. Anthony GS, Fisher J, Courts JRT, Calder AA. Forces required for surgical dilatation of the pregnant and non-pregnant human cervix. Br J Obstet Gynaecol 1982; 89: 913–916.
9. Richardson W, Smith DC, Evans AL, Anthony GS. A novel cervical dilatation force measurement instrument. J Med Eng Technol 1989; 13: 220–221.
10. Shaker AG, Fleming R, Jamieson ME, Yates RWS, Courts JRT. Assessments of embryo transfer after in-vitro fertilization: effects of glyceryl trinitrate. Hum Reprod 1993; 8: 1426–1428.
11. Yadava RP. Sublingual glyceryl trinitrate spray facilitates IUD insertion. BrJ Sexual Med 1990; 7: 217.
12. Lees C, Campbell S, Jauniaux E et al. Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor. Lancet 1994; 343: 1325–1326.
13. Calder AA, Greer IA. Cervical physiology and induction of labour. In: Bonnar J, editor. Recent Advances in Obstetrics and Gynaecology. Edinburgh: 1992; 17: 33–56.
14. Liggins GC. Cervical ripening as an inflammatory reaction. In: Ellwood DA, Anderson ABM, editors. The Cervix in Pregnancy and Labour: Clinical and Biochemical Investigations. Edinburgh : 1981; 1–9.
15. Lanaro A, O’Donnell CA, Di Rosa M, Liew FY. A nitric oxide synthase inhibitor reduces inflammation, down regulates inflammatory cytokines and enhances JL-10 production in carrageenin-induced mice. Immunology 1994; 82: 370–375.
16. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc NatlAcadSci 1993; 90:7240–7244.
17. Trachtman H, Futterweit S, Garg P, Reddy K, Singhal PC. Nitric oxide stimulates the activity of a 72-kDa neutral matrix metalloproteinase in cultured rat mesangial cells. Biochem Biophys Res Commun 1996; 218: 704–708.
18. Henshaw RC, Templeton AA. Pre-operative cervical preparation before first trimester vacuum aspiration: a randomized controlled comparison between gemeprost and mifepristone (RU486). Br J Ohstet Gynaecol 1991; 98: 1025–1030.
19. Helm CW, Davies N, Beard RJ. A comparison of gemeprost (Cervagem) pessaries and Lamicel tents for cervical preparation for abortion by dilatation and suction. Br J Obstet Gynaecol 1988; 95: 911–915.
20. Norman J. Nitric oxide and the myometrium. Pharrnacol Ther 1996; 70:91–100.