Immune-mediated clearance of virus from the central nervous system

Microbes and Infection

Volumn 5, Issue 5, 2003, Pages 439-448

  Binder, Gwendolyn K ^a,b   Griffin, Diane E ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b VIRxSYS Corporation   (United States)

Author keywords

Central nervous system; Immune system; Virus replication

Indexed keywords

ANTIBODY; CYTOKINE;

ANTIBODY RESPONSE; BORNA DISEASE VIRUS; CELL TYPE; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM; CYTOTOXIC T LYMPHOCYTE; GLIA CELL; HEPATITIS VIRUS; HUMAN; IMMUNE RESPONSE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MURINE ENCEPHALOMYELITIS VIRUS; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; RABIES VIRUS; REVIEW; SINDBIS VIRUS; TARGET CELL; VIRUS INFECTION; VIRUS PATHOGENESIS;

EID: 0037651329     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(03)00047-9     Document Type: Review

References (60)

1. Cserr H.F., Knopf P.M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today. 13:1992;507-512.
2. Hickey W.F. Leukocyte traffic in the central nervous system: the participants and their roles. Semin. Immunol. 11:1999;125-137.
3. Hickey W.F. Basic principles of immunological surveillance of the normal central nervous system. Glia. 36:2001;118-124.
4. Tyor W.R., Wesselingh S., Levine B., Griffin D.E. Long term intraparenchymal Ig secretion after acute viral encephalitis in mice. J. Immunol. 149:1992;4016-4020.
5. Santambrogio L., Sato A.K., Carven G.J., Belyanskaya S.L., Strominger J.L., Stern L.J. Extracellular antigen processing and presentation by immature dendritic cells. Proc. Natl. Acad. Sci. USA. 96:1999;15056-15061.
6. Lampson L.A. Molecular bases of the immune response to neural antigens. Trends Neurosci. 10:1987;211-216.
7. Irani D.N., Lin K.I., Griffin D.E. Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells. J. Immunol. 157:1996;4333-4340.
8. Stoll G., Jander S., Schroeter M. Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J. Neural Transm. Suppl. 59:2000;81-89.
9. Levine B., Hardwick M.J., Trapp B.D., Crawford T.O., Bollinger B.C., Griffin D.E. Antibody-mediated clearance of alphavirus infection from neurons. Science. 254:1991;856-860.
10. Levine B., Griffin D.E. Persistence of viral mRNA in mouse brains after recovery from acute alpha encephalitis. J. Virol. 66:1992;6429-6435.
11. Binder G.K., Griffin D.E. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science. 293:2001;303-306.
12. Ubol S., Levine B., Lee S.H., Greenspan N.S., Griffin D.E. Roles of immunoglobulin valency and the heavy-chain constant domain in antibody-mediated downregulation of Sindbis virus replication in persistently infected neurons. J. Virol. 69:1995;1990-1993.
13. Despres P., Griffin J.W., Griffin D.E. Effects of anti-E2 monoclonal antibody on Sindbis virus replication in AT3 cells expressing bcl-2. J. Virol. 69:1995;7006-7014.
14. Despres P., Griffin J.W., Griffin D.E. Antiviral activity of alpha interferon in Sindbis virus-infected cells is restored by anti-E2 monoclonal antibody treatment. J. Virol. 69:1995;7345-7348.
15. Kimura T., Griffin D.E. The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J. Virol. 74:2000;6117-6125.
16. Wesselingh S.L., Griffin D.E. Local cytokine responses during acute and chronic viral infections of the central nervous system. Virology. 5:1994;457-463.
17. Wesselingh S.L., Levine B., Fox R.J., Choi S., Griffin D.E. Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response. J. Immunol. 152:1994;1289-1297.
18. Rowell J.F., Griffin D.E. The inflammatory response to nonfatal Sindbis virus infection of the nervous system is more severe in SJL than in BALB/c mice and is associated with low levels of IL-4 mRNA and high levels of IL-10-producing CD4+ T cells. J. Immunol. 162:1999;1624-1632.
19. Griffin D.E., Mendoza Q.P. Identification of the inflammatory cells present in the central nervous system of normal and mast cell-deficient mice during Sindbis virus encephalitis. Cell. Immunol. 97:1986;454-459.
20. Gehrmann J., Matsumoto Y., Kreutzberg G.W. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Rev. 20:1995;269-287.
21. Dietzschold B., Kao M., Zheng Y.M., Chen Z.Y., Maul G., Fu Z.F., Rupprecht C.E., Koprowski H. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc. Natl. Acad. Sci. USA. 89:1992;7252-7256.
22. Prabhakar B.S., Fischman H.R., Nathanson N. Recovery from experimental rabies by adoptive transfer of immune cells. J. Gen. Virol. 56:1981;25-31.
23. Hooper D.C., Morimoto K., Bette M., Weihe E., Koprowski J., Dietzschold B. Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. J. Virol. 72:1998;3711-3719.
24. Dietzschold B., Morimoto K., Hooper D.C. Mechanisms of virus-induced neuronal damage and the clearance of viruses from the CNS. Curr. Top. Microbiol. Immunol. 253:2001;145-155.
25. Pearce B.D., Hobbs M.V., McGraw T.S., Buchmeier M.J. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo. J. Virol. 68:1994;5483-5495.
26. Hatalski C.G., Hickey W.F., Lipkin W.I. Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. J. Neuroimmunol. 90:1998;128-136.
27. Hatalski C.G., Hickey W.F., Lipkin W.I. Evolution of the immune response in the central nervous system following infection with Borna disease virus. J. Neuroimmunol. 90:1998;137-142.
28. Oldstone M.B.A., Blount P., Southern P.J. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature. 321:1986;239-243.
29. Tishon A., Eddleston M., de la Torre J.C., Oldstone M.B. Cytotoxic T lymphocytes cleanse viral gene products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus. Virology. 197:1993;463-467.
30. Rodriguez M., Lindsley M.D., Pierce M.L. Role of T cells in resistance to Theiler's virus infection. Microb. Pathog. 11:1991;269-281.
31. Murray P.D., Pavelko K.D., Leibowitz J., Lin X., Rodriguez M. CD4+ and CD8+ T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J. Virol. 72:1998;7320-7329.
32. Rossi C.P., McAllister A., Tanguy M., Kagi D., Brahic M. Theiler's virus infection of perforin-deficient mice. J. Virol. 72:1998;4515-4519.
33. Olson J.K., Girvin A.M., Miller S.D. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J. Virol. 75:2001;9780-9789.
34. Chang J.R., Zaczynska E., Katsetos C.D., Platsoucas C.D., Oleszak E.L. Differential expression of TGF-beta, IL-2, and other cytokines in the CNS of Theiler's murine encephalomyelitis virus-infected susceptible and resistant strains of mice. Virology. 278:2000;346-360.
35. Njenga M.K., Asakura K., Hunter S.F., Wettstein P., Pease L.R., Rodriguez M. The immune system preferentially clears Theiler's virus from the gray matter of the central nervous system. J. Virol. 71:1997;8592-8601.
36. Fujinami R.S., Rosenthal A., Lampert P.W., Zurbriggen A., Yamanda M. Survival of athymic (nu/nu) mice after Theiler's murine encephalomyelitis virus infection by passive administration of neutralizing monoclonal antibody. J. Virol. 63:1989;2081-2087.
37. Sussman M.A., Shubin R.A., Kyuwa S., Stohlman S.A. T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system. J. Virol. 63:1989;3051-3056.
38. Gombold J.L., Sutherland R.M., Lavi E., Paterson Y., Weiss S.R. Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb. Pathog. 18:1995;211-221.
39. Gombold J.L., Weiss S.R. Mouse hepatitis virus A59 increases steady-state levels of MHC mRNAs in primary glial cell cultures and in the murine central nervous system. Microb. Pathog. 13:1992;493-505.
40. Lin M.T., Stohlman S.A., Hinton D.R. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis. J. Virol. 71:1997;383-391.
41. Wu G.F., Dandekar A.A., Pewe L., Perlman S. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J. Immunol. 165:2000;2278-2286.
42. Pewe L., Perlman S. Cutting edge: CD8 T cell-mediated demyelination is IFN-{gamma} dependent in mice infected with a neurotropic coronavirus. J. Immunol. 168:2002;1547-1551.
43. Parra B., Hinton D.R., Marten N.W., Bergmann C.C., Lin M.T., Yang C.S., Stohlman S.A. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J. Immunol. 162:1999;1641-1647.
44. Ramakrishna C., Stohlman S.A., Atkinson R.D., Shlomchik M.J., Bergmann C.C. Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells. J. Immunol. 168:2002;1204-1211.
45. Matthews A.E., Weiss S.R., Shlomchik M.J., Hannum L.G., Gombold J.L., Paterson Y. Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver. J. Immunol. 167:2001;5254-5263.
46. Zinkernagel R.M., Doherty P.C. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis virus within a syngeneic or semiallogenic system. Nature. 248:1974;701-703.
47. Joly E., Mucke L., Oldstone M.B.A. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science. 253:1991;1283-1285.
48. Rall G.F., Mucke L., Oldstone M.B. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J. Exp. M. 182:1995;1201-1212.
49. Guidotti L.G., Chisari F.V. Cytokine-mediated control of viral infections. Virology. 273:2000;221-227.
50. Ramsay A.J., Ruby J., Ramshaw I.A. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today. 14:1993;155-157.
51. Ramshaw I.A., Ramsay A.J., Karupiah G., Rolph M.S., Mahalingam S., Ruby J.C. Cytokines and immunity to viral infections. Immunol. Rev. 159:1997;119-135.
52. Schijns V.E.C.J., Van der Neut R., Haagmans B.L., Bar D.R., Schellekens H., Horzinek M.C. Tumor necrosis factor-α, interferon-γ and interferon-β exert antiviral activity in nervous tissue cells. J. Gen. Virol. 72:1991;809-815.
53. Franco M.A., Greenberg H. Role of B cells and cytotoxic lymphocytes in clearance of rotavirus infection in mice. J. Virol. 69:1995;7800-7806.
54. Gaertner D.J., Jacoby R.O., Johnson E.A., Paturzo F.X., Smith A.L. Persistent rat virus infection in juvenile athymic rats and its modulation by immune serum. Lab. Anim. Sci. 45:1995;249.
55. Goldman M.B., O'Bryan T.A., Buckthal D.J., Tetor L.M., Goldman J.N. Suppression of measles virus expression by noncytolytic antibody in an immortalized macrophage cell line. J. Virol. 69:1995;734-740.
56. Manzanec M.B., Coudret C.L., Fletcher D.R. Intracellular neutralization of influenza virus by immunoglobulin A anti-hemagglutinin monoclonal antibodies. J. Virol. 69:1994;1339-1343.
57. Palladino G., Mozdzanowska K., Washko G. Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J. Virol. 69:1995;2075-2081.
58. Scherle P.A., Palladino G., Gerhard W. Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells. J. Immunol. 148:1992;212-217.
59. Weinmann-Dorsch C., Koschel K. Coupling of viral membrane proteins to phosphatidylinositide signalling system. FEBS Lett. 247:1989;185-188.
60. Asensio V.C., Campbell I.L. Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci. 22:1999;504-512.