Regulation of Nrf2-mediated induction of glutamate cysteine ligase modulatory gene (GCLM) expression: Considerations for future studies

Toxicological Sciences

Volumn 73, Issue 1, 2003, Pages 1-3

  Walsh, Anne C ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; GLUTAMATE CYSTEINE LIGASE; MITOGEN ACTIVATED PROTEIN KINASE; PYRROLIDINE DITHIOCARBAMATE; RESVERATROL; SULFORAPHANE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CELL PROTECTION; CELL STRAIN HEPG2; DETOXIFICATION; ENZYME INDUCTION; FUTUROLOGY; GENE CONTROL; GENE EXPRESSION; HUMAN; KNOCKOUT MOUSE; LINKAGE ANALYSIS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; TRANSACTIVATION;

EID: 0037648957     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg085     Document Type: Article

References (14)

1. Cho, H., Jedlicka, A. E., Reddy, S. P. M., Zhang, L., Kensler, T. W., and Kleeberger, S. R. (2002). Linkage analysis of susceptibility to hyperoxia: Nrf2 is a candidate gene. Am. J. Respir. Cell. Mol. Biol. 26, 42-51.
2. Dhakshinamoorthy, S., and Jaiswal, A. K. (2001). Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene 20, 3906-3917.
3. Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., and Talalay, P. (2002). Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. U.S.A. 99, 11908-11913.
4. Galloway, D. C., Blake, D. G., and McLellan, L. I. (1999). Regulation of gamma-glutamylcysteine synthetase regulatory subunit (GLCLR) gene expression: Identification of the major transcriptional start site in HT29 cells. Biochim. Biophys. Acta 1446, 47-56.
5. Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., and Yamamoto, M. (1999). KEAP1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76-86.
6. Kwak, M., Itoh, K., Yamamoto, M., and Kensler, T. W. (2002). Enhanced expression of the transcription factor Nrf2 by cancer chemopreventative agents: Role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol. 22, 2883-2892.
7. Moinova, H. R., and Mulcahy, R. T. (1998). An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. J. Biol. Chem. 273, 14683-14689.
8. Nakamura, S., Kugiyama, K., Sugiyama, S., Miyamoto, S., Koide, S., Fukushima, H., Honda, O., Yoshimura, M., and Ogawa, H. (2002). Polymorphism in the 5′-flanking region of human glutamatecysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 105, 2968-2973.
9. Nguyen, T., Huang, H. C., and Pickett, C. B. (2000). Transcriptional regulation of the antioxidant response element. J. Biol. Chem. 275, 15466-15473.
10. Sekhar, K. R., Spitz, D. R., Harris, S., Nguyen, T., Meredith, M. J., Holt, J. T., Guis, D., Marnett, L. J., Summar, M. L., and Freeman, M. L. (2002a). Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic. Biol. Med. 32, 650-662.
11. Sekhar, K. R., Yan, X. X., and Freeman, M. L. (2002b). Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. Oncogene 21, 6829-6834.
12. Walsh, A. C., Feulner, J. A., and Reilly, A. (2001). Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: Association with glutathione levels and drug resistance in the National Cancer Institute Tumor Cell Line Panel. Toxicol. Sci. 61, 218-223.
13. Wild, A. C., Moinova, H. R., and Mulcahy, R. T. (1999). Regulation of γ-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J. Biol. Chem. 274, 33627-33636.
14. Zipper, L. M., and Mulcahy, R. T. (2000). Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochem. Biophys. Res. Commun. 278, 484-492.