Decreased lymphocyte 3H-paroxetine binding in obsessive-compulsive disorder

Neuropsychobiology

Volumn 47, Issue 3, 2003, Pages 128-130

  Marazziti, Donatella ^a   Baroni, Stefano ^a   Masala, Irene ^a   Giannaccini, Gino ^a   Mungai, Francesco ^a   Di Nasso, Elena ^a   Cassano, Giovanni B ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

3H Paroxetine binding; Blood lymphocytes; Obsessive compulsive disorder; Serotonin; Serotonin transporter

Indexed keywords

PAROXETINE; SEROTONIN TRANSPORTER; ANTIDEPRESSANT AGENT; CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE MEMBRANE; MALE; OBSESSIVE COMPULSIVE DISORDER; OUTCOMES RESEARCH; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STANDARDIZATION; STATISTICAL SIGNIFICANCE; BINDING SITE; METABOLISM; PHYSIOLOGY;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BINDING SITES; CARRIER PROTEINS; FEMALE; HUMANS; LYMPHOCYTES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; OBSESSIVE-COMPULSIVE DISORDER; PAROXETINE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0037641279     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070580     Document Type: Article

References (13)

1. Insel TR, Mueller EA, Alterman L, Linnoila M, Murphy DL: Obsessive-compulsive disorder and serotonin. Is there a connection? Biol Psychiatry 1985;20:1174-1188.
2. Thoren P, Åsberg M, Cronholm B: Clomipramine treatment of obsessive-compulsive disorder: A controlled clinical trial. Arch Gen Psychiatry 1980;37:1281-1289.
3. Åsberg M, Thoren P, Bertilsson L: Clomipram-ine treatment of obsessive disorder: Biochemical and clinical aspects. Psychopharmacol Bull 1981;18:13-21.
4. 3H-paroxetine binding in obsessive-compulsive patients. Neuropsychobiology 1996;34: 184-187.
5. Marazziti D, Masala I, Rossi A, Hollander E, Presta S, Giannaccini G, Mazzoni MR, Dell'Osso L, Lucacchini A, Cassano GB: Increased inhibitory activity of protein kinase C on the serotonin transporter in OCD. Neuro-psychobiology 2000;41:171-177.
6. Sallee FR, Richman H, Beach K, Sethuram G, Nesbitt L: Platelet serotonin transporter in children and adolescents with obsessive-compulsive disorder or Tourette's syndrome. J Am Acad Child Adol Psychiatry 1996;35:1647-1656.
7. Marazziti D, Rossi A, Giannaccini G, Baroni S, Lucacchini A, Cassano GB: Presence and characterization of the serotonin transporter in human resting lymphocytes. Neuropsychopharmacology 1998;19:154-159.
8. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4, revised. Washington, American Psychiatric Association, 1994.
9. Goodman WK, Price LH, Rasmussen SA: The Yale-Brown Obsessive Compulsive Scale. I: Development, use and reliability. Arch Gen Psychiatry 1989;46:1006-1011.
10. Peterson GL: A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 1977;83:356-366.
11. McPherson GA: Kinetic, EBDA, LIGAND: Lowry: A Collection of Radioligand Binding Analysis Programs. Cambridge, Biosoft, 1985
12. McPherson GA: Kinetic, EBDA, LIGAND: Lowry: A Collection of Radioligand Binding Analysis Programs. Cambridge, Biosoft, 1985. Lesch KP, Bengel D, Heils A, Sabol SZ, Green-berg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
13. Marazziti D, Akiskal HS, Rossi A, Cassano GB: Alteration of the platelet serotonin transporter in romantic love. Psychol Med 1999;29: 741-745.