Platelet serotonin transporter in children and adolescents with obsessive-compulsive disorder or Tourette's syndrome

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 35, Issue 12, 1996, Pages 1647-1656

  Sallee, Floyd R ^a,d   Richman, Harvey ^b   Beach, Kevin ^a   Sethuraman, Gopalan ^a   Nesbitt, Lori ^c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b School of Business   (United States)

^c UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

3H paroxetine; obsessive compulsive disorder; platelet; serotonin transporter; Tourette's syndrome

Indexed keywords

CARRIER PROTEIN; PAROXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GILLES DE LA TOURETTE SYNDROME; HUMAN; MALE; OBSESSION; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCHOOL CHILD; SEROTONIN UPTAKE; THROMBOCYTE;

EID: 0029824489     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-199612000-00017     Document Type: Article

References (70)

1. Ambrosini PJ, Metz C, Arora RC, Lee J, Kregel L, Meltzer HY (1992) Platelet imipramine binding in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 31:298-305
2. Anderson GM, Pollack ES, Chatterjee D, Leckman JF, Riddle MA, Cohen DJ (1992), Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome. Adv Neurol 58:123-133
3. 3H]Paroxetine binding in human platelets in relation to age and sex. Neurobiol Aging 11:615-618
4. Apter A, Ratzoni G, King RA et al. (1994), Fluvoxamine open-label treatment of adolescent inpatients with obsessive compulsive disorder or depression. J Am Acad Child Adolesc Psychiatry 33:342-348
5. Arora RC, Fichtner CG, O'Connor F, Crayton JW (1993), Paroxetine binding in the blood platelets of post-traumatic stress disorder patients. Life Sci 53:919-928
6. Bastani B, Arora RC, Meltzer HY (1991), Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients. Biol Psychiatry 30:131-139
7. Bellodi L, Sciuto G, Diaferia G, Ronchi P, Smeraldi E (1992), Psychiatric disorders in the families of patients with obsessive-compulsive disorder. Psychiatry Res 42:111-120
8. Benkelfat C, Murphy DL, Zohar J et al. (1989), Clomipramine in obsessive-compulsive disorder. Arch Gen Psychiatry 47:840-848
9. Black DW, Kelly M, Myers C, Noyes R (1990), Tritiated imipramine binding in obsessive compulsive volunteers and psychiatrically normal controls. Biol Psychiatry 27:319-327
10. Butler IJ, Koslow SH, Seifert WE, Caprioli RM, Singer HS (1979), Biogenic amine metabolism in Tourette syndrome. Ann Neurol 6:37-39
11. Chambers WJ, Puig-Antich J, Hirsch M et al. (1985), The assessment of affective disorders in children and adolescents by semistructured interview. Arch Gen Psychiatry 42:696-702
12. 3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology 32:737-743
13. Cohen DJ, Leckman JF, Shaywitz BA (1985), The Tourette syndrome and other tics. In: The Clinical Guide to Child Psychiatry. New York: Free Press
14. Cohen DJ, Shaywitz BA, Caparulo B, Young JG, Bowers MB (1978), Chronic multiple tics of Gilles de la Tourette's disease: CSF acid monoamine metabolites after probenecid administration. Arch Gen Psychiatry 35:245-250
15. Comings DE, Himes JA, Comings BG (1990), An epidemiologic study of Tourette's syndrome in a single school district. J Clin Psychiatry 51:463-469
16. Cook EH, Arora RC, Anderson GM et al. (1993), Platelet serotonin studies in hyperserotonergic relatives of children with autistic disorder. Life Sci 52:2005-2015
17. DeVane CL, Sallee FR (1996), Selective serotonin reuptake inhibitors in child and adolescent psychopharmacology: a review of published experience. J Clin Psychiatry 57:55-66
18. 3H-imipramine binding in panic disorder patients and healthy controls. J Psychiatry Neurosci 19:109-113
19. Geller DA, Biederman J, Reed ED et al. (1995), Similarities in response to fluoxetine in the treatment of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 34:36-44
20. George MS, Trimble MR, Ring HA, Sallee FR, Robertson MM (1993), Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette's syndrome. Am J Psychiatry 150:93-97
21. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996), Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612
22. Goodman WK, McDougle CJ, Price LH et al. (1995), m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: absence of symptom exacerbation. Biol Psychiatry 38:138-149
23. Goodman WK, Price LH, Rasmussen SA et al. (1989), The Yale-Brown Obsessive Compulsive Scale: II. Validity. Arch Gen Psychiatry 46:1012-1016
24. Hanna GL, McCracken JT, Cantwell DP (1991), Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. J Am Acad Child Adolesc Psychiatry 30:173-178
25. Hanna GL, Yuwiler A, Coates JK (1995), Whole blood serotonin and disruptive behaviors in juvenile obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 34:28-35
26. Harcherik DF, Leckman JF, Detlor J, Cohen DJ (1984), A new instrument for clinical studies of Tourette's syndrome. J Am Acad Child Psychiatry 23:153-160
27. Holzer J, Goodman WK, Price LH, Bear L, Leckman JF, Heninger GR (1994), Obsessive compulsive disorder with and without a chronic tic disorder: a comparison of symptoms in 70 patients. Br J Psychiatry 164:469-473
28. Insel TR (1992), Toward a neuroanatomy of obsessive-compulsive disorder. Arch Gen Psychiatry 49:739-744
29. Insel TR, Mueller EA, Alterman I, Linnoila M, Murphy DL (1985), Obsessive-compulsive disorder and serotonin: is there a contradiction? Biol Psychiatry 20:1174-1188
30. 3H]paroxetine binding on human platelets. Soc Biol Psychiatry 36:281-291
31. Jacobs BL, Fornal CA (1995), Serotonin and behavior: a general hypothesis. In: Psychobiology: The Fourth Generation of Progress, Bloom FE, Kupfer DJ, eds. New York: Raven Press
32. 3H-imipramine binding sites in obsessive-compulsive behavior. Biol Psychiatry 30:467-474
33. 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference. Soc Biol Psychiatry 28:509-517
34. Kurlan R, Como P, Deeley C, McDermott M, McDermott MP (1993), A pilot controlled study of fluoxetine for obsessive-compulsive symptoms in children with Tourette's syndrome. Clin Neuropharmacol 16:167-172
35. 3H]Paroxetine binding to human platelets: clues to a selectivity paradox from temperature studies. Br J Pharmacol 96:303-309
36. Leckman JF, Anderson GM, Cohen et al. (1984), Whole blood serotonin and tryptophan levels in Tourette's disorder: effects of acute and chronic clonidine treatment. Life Sci 35:2497-2503
37. Leckman JF, Goodman WK, Anderson GM et al. (1995), Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's disorder, and healthy controls. Neuropsychopharmacology 12:73-86
38. Leckman JF, Goodman WK, North WG et al. (1994), Elevated levels of CSF oxytocin in obsessive compulsive disorder: comparison with Tourette's syndrome and healthy controls. Arch Gen Psychiatry 51:782-792
39. Leonard HL, Swedo SE, Lenane MC et al. (1993), A 2-to 7-year follow-up study of 54 obsessive-compulsive children and adolescents. Arch Gen Psychiatry 50:429-439
40. Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL (1995), Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 37:215-223
41. Lowry DH, Rosebrough HJ, Farr AL, Randall RJ (1951), Protein measurement with Folin phenol reagent. J Biol Chem 193:265-275
42. Lydiard RB, Ballenger JC, Ellinwood E et al. (1990), CSF monoamine metabolites in obsessive-compulsive disorder. Poster presented at the American Psychiatric Association meeting, New York, May 5
43. 3H-paroxetine binding to platelets from healthy volunteers. Biol Psychiatry 34:356-360
44. Marcusson JO, Andersson A, Backstrom I (1989), Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain. Psychopharmacology 99:17-21
45. McDougle CJ, Goodman WK, Leckman JF, Barr LC, Heninger GR, Price LH (1993), The efficacy of fluvoxamine in obsessive compulsive disorder: effects of comorbid chronic tic disorder. J Clin Psychopharmacol 13:354-358
46. McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH (1994), Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder: a double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry 51:302-308
47. McDougle CJ, Goodman WK, Price LH et al. (1990), Neuroleptic addition in fluvoxamine-refractory obsessive compulsive disorder. Am J Psychiatry 146:652-654
48. 3H-imipramine binding. Acta Psychiatr Scand 82:330-334
49. Mundo E, Deliodi L, Smeraldi E (1995), Effects of acute intravenous clomipramine on obsessive-compulsive symptoms and response to chronic treatment. Biol Psychiatry 38:525-531
50. Munson PJ, Rodbard D (1980), A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
51. Owens MJ, Nemeroff CB (1994), Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40:288-295
52. Pauls DL, Alsobrook JP, Phil M, Goodman W, Rasmussen S, Leckman JF (1995), A family study of obsessive-compulsive disorder. Am J Psychiatry 152:76-84
53. Pauls DL, Leckman JF (1986), The inheritance of Gilles de la Tourette's syndrome and associated behaviors: evidence for an autosomal dominant transmission. N Engl J Med 315:993-997
54. Ramamoorthy S, Bauman AL, Moore KR et al. (1993), Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning expression, and chromosomal localization. Proc Natl Acad Sci USA 90-2542-2546
55. Rasmussen SA, Eisen JL (1990), Epidemiology of obsessive-compulsive disorder. J Clin Psychiatry 51(2 suppl):10-13
56. 3H-imipramine binding in platelets of children and adolescents with major affective disorders. Psychiatry Res 13:31-39
57. Riddle MA, Hardin MT, King R et al. (1990), Fluoxetine treatment of children and adolescents with Tourette's and obsessive compulsive disorders: preliminary clinical experience. J Am Acad Child Adolesc Psychiatry 29:45-48.
58. Riddle MA, Scahill L, King RA et al. (1992), Double-blind trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 31:1062-1069
59. Sallee FR, Nesbitt L, Dougherty D, Hilal R, Nandagopal VS, Sethuraman G (1995), Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent MDD. Psychopharmacol Bull 31:339-345
60. Seifert WE, Foxx JL, Butler IJ (1980), Age effect on dopamine and serotonin metabolite levels in cerebrospinal fluid. Ann Neurol 8:38-42
61. Singer HS, Walkup JT (1991), Tourette syndrome and other tic disorders: diagnosis, pathophysiology, and treatment. Medicine 70:15-32
62. Stein MB, Uhde TW (1995), Biology of anxiety disorders. In: The American Psychiatric Press Textbook of Psychopharmacology, Schatzburg AF, Nemeroff CB, eds Washington, DC: American Psychiatric Press
63. Thoren P, Asberg M, Bertilsson L et al. (1980), Clomipramine treatment of obsessive-compulsive disorder: II. Biochemical aspects. Arch Gen Psychiatry 37:1289-1295
64. Vitello B, Shimon H, Behar D, Stoff D, Bridger WH, Friedman E (1991), Platelet imipramine binding in obsessive-compulsive parents. Acta Psychiatr Scand 84:29-32
65. Walkup JT, Rosenberg LA, Brown J, Singer H (1992), The validity of instruments measuring tic severity in Tourette's syndrome. J Am Acad Child Adolesc Psychiatry 31:472-477
66. Weizman A, Carmi M, Hermesh H et al. (1986), High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients. Am J Psychiatry 143:335-339
67. Weizman A, Mandel A, Barber Y et al. (1992), Decreased platelet imipramine binding in Tourette syndrome children with obsessive-compulsive disorder. Biol Psychiatry 31:705-711
68. Yehuda R, Boisoneau D, Lowy MT, Giller EL (1995), Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 52:583-593
69. Young JG, Cohen DJ, Anderson GM, Shaywitz BA (1984), Neurotransmitter ontogeny as a perspective for studies of child development and pathology. In: The Psychology of Childhood, Greenhill L, Shopsin B, eds New York: Spectrum Publications, pp 51-84
70. Zohar J, Insel TR (1987), Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology. Biol Psychatry 22:667-687