Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues

Cancer Letters

Volumn 196, Issue 2, 2003, Pages 153-159

  Kapucuoglu, Nilgün ^a   Coban, Tulay ^b   Raunio, Hannu ^c   Pelkonen, Olavi ^c   Edwards, Robert J ^d   Boobis, Alan R ^d   Iscan, Mumtaz ^b  

^a ANKARA ONCOLOGY HOSPITAL   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c UNIVERSITY OF OULU   (Finland)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Breast tumour; Cytochrome P4502E1; Estrogen receptor status; Immunohistochemistry; Menopausal status

Indexed keywords

ANTIBODY; CYTOCHROME P450 2E1;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; BREAST TUMOR; CANCER TISSUE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOCHEMISTRY; CYTOPLASM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

NICOTIANA TABACUM;

EID: 0037631011     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00277-5     Document Type: Article

References (31)

1. Davis D.L., Bradlow H.L., Wolff M., Woodruf T., Hoel D.G., Anton V., Culver H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ. Health Perspect. 101:1993;372-377.
2. Morris J.J., Seifter E. The role of aromatic hydrocarbons in the genesis of breast cancer. Med. Hypothesis. 38:1992;177-184.
3. Russo J., Russo I.H. Cellular basis of breast cancer susceptibility. Oncol. Res. 11:1999;169-178.
4. Nebert D.W. Role of genetics and drug metabolism in human cancer risk. Mutat. Res. 247:1991;267-281.
5. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
6. Maltoni C., Ciliberti A., Cotti G., Conti B., Belpoggi F. Benzene:an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ. Health Perspect. 82:1989;109-124.
7. Guengerich F.P., Kim D.H., Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of several low molecular weight cancer suspects. Chem. Res. Toxicol. 4:1991;168-179.
8. Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol. Rev. 77:1997;517-544.
9. Ames B., Gold L.S., Willett W.C. The cause and prevention of cancer. Proc. Natl Acad. Sci. 92:1995;5258-5265.
10. Takashi T., Lasker J.M., Rosman A.S., Lieber C.S. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology. 17:1993;236-245.
11. Singletary K.W., McNary M.Q., Odoms A.M., Nelshoppen J., Wallig M.A. Ethanol consumption and DMBA-induced mammary carcinogenesis in rats. Nutr. Cancer. 16:1991;13-23.
12. Singletary K.W., Nelshoppen J., Wallig M.A. Enhancement by chronic ethanol intake of N-methyl-N-nitrosourea-induced rat mammary tumorigenesis. Carcinogenesis. 16:1995;959-964.
13. Willett W.C. Nutrition and cancer. Salud Publica Mex. 39:1997;298-309.
14. Hellmold H., Rylander T., Magnusson M., Reihner E., Warner M., Gustafsson J.-A. Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. J. Clin. Endocrinol. Metab. 83:1998;886-895.
15. Iscan M., Klaavuniemi T., Coban T., Kapucuoglu N., Pelkonen O., Raunio H. The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. Breast Cancer Res. Treat. 70:2001;47-54.
16. Albin N., Massaad L., Toussaint C., Matthieu M.C., Morizet J., Parise O., Gouyette A., Chabot G.G. Main drug-metabolizing enzyme systems in human breast tumors and peritumoral tissues. Cancer Res. 53:1993;3541-3546.
17. Pertshuck L.P., Kim D.S., Nayer K., Feldman J.G., Eisenbag K.B., Carter A.C., Rong Z.T., Thelmo W.L., Fleisher J., Greene L. Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic and biochemical correlations and relationship to endocrine response and survival. Cancer. 66:1990;1661-1670.
18. Edwards R.J., Adams D.A., Watts P.S., Davies D.S., Boobis A.R. Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. Biochem. Pharmacol. 56:1998;377-387.
19. Hsu S.M., Raino L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem. 29:1981;577-580.
20. Murray G.I., Weaver R.J., Paterson P.J., Ewen S.W.B., Melvin W.T., Burke M.D. Expression of xenobiotic metabolizing enzymes in breast cancer. J. Pathol. 169:1993;347-353.
21. McKay J.A., Melvin W.T., Ah-See A.K., Ewen S.W.B., Greenlee W.F., Marcus C.B., Burke M.D., Murray G.I. Expression of cytochrome P450 1B1 in breast cancer. FEBS Lett. 374:1995;270-272.
22. Murray G.I., Taylor M.C., McFayden M.C., McKay J.A., Greenlee W.F., Burke M.D., Melvin W.T. Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. 57:1997;3026-3031.
23. McFadyen M.C., Breeman S., Payne S., Stirk C., Miller I.D., Melvin W.T., Murray G.I. Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. J. Histochem. Cytochem. 47:1999;1457-1464.
24. Forrester L.M., Hayes J.D., Millis R., Barnes D., Harris A.L., Schlager J.J., Powis G., Wolf C.R. Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue. Carcinogenesis. 11:1990;2163-2170.
25. Yokose T., Doy M., Taniguchi T., Shimada T., Kakiki M., Horie T., Matsuzaki Y., Mukai K. Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues. Virchows Arch. 434:1999;401-411.
26. Eltom S.E., Larsen M.C., Jefcoate C.R. Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor. Carcinogenesis. 19:1998;1437-1444.
27. Larsen M.C., Angus W.G.R., Brake P.B., Eltom S.E., Sukow K.A., Jefcoate C.R. Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Res. 58:1998;2366-2374.
28. Spink D.C., Spink B.C., Cao J.Q., DePasquale J.A., Pentecost B.T., Fasco M.J., Li Y., Sutter T.R. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis. 19:1998;291-298.
29. Shenton K.C., Dowsett M., Lu Q., Brodie A., Sasano H., Sacks N.P., Rowlands M.G. Comparison of biochemical aromatase activity with aromatase immunohistochemistry in human breast carcinomas. Breast Cancer Res. Treat. 49:(suppl 1):1998;S101-S107.
30. Zhang Z., Yamashita H., Toyama T., Hara Y., Omoto Y., Sugiura H., Kobayashi S., Harada N., Iwase H. Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast. Breast Cancer Res. Treat. 74:2002;47-53.
31. Angus W.G.R., Larsen M.C., Jefcoate C.R. Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. Carcinogenesis. 20:1999;947-955.