Blockade of p38 mitogen-activated protein kinase pathway inhibits interleukin-6 release and expression in primary neonatal cardiomyocytes

Research Communications in Molecular Pathology and Pharmacology

Volumn 110, Issue 3-4, 2001, Pages 209-228

  Chae, Hanjung ^a,c   Lee, Junki ^a   Byun, Joungouk ^a   Jung, Wooyoung ^b   Kwak, Yonggeun ^c   Chae, Soowan ^c   Kim, Hyungryong ^a,b  

^a Wonk Wang University   (South Korea)

^b Wonkwang University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Electrophoretic mobility shift assay (EMSA); IFN ; Immunoblotting; Induction of IL 6; LPS; MAPK; Mitogen activation; Myocytes; Neonatal cardiomyocytes; Northern blotting; Proinflammatory agents; Protein kinase; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME INHIBITION; GENE EXPRESSION; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DRUG INTERACTIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; IMIDAZOLES; INTERFERON TYPE II; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037623373     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ahn, Y.S., Kim, C.H., Kim, J.H. (1999). Role of protein kinases on NF-κB activation and cell death in bovine cerebral endothelial cells. Korean J Physiol Pharmacol.3:11-18.
2. Akira, S., Hirano, T., Taga, T., Kishimoto, T. (1990). Biology of multifunctional cytokines: IL6 and related molecules (IL 1 and TNF). FASEB J. 4(11):260-267.
3. Awane, M., Andres, P.G., Li, D.J., Reinecker, H., C. (1999). NF-κB-inducing kinase is a common mediator of IL-17-, TNF-α-, and IL-1β-induced chemokine promoter activation in intestinal epithelial cells. J Immunol. 162:5337-5344.
4. Beyaert, R., Cuenda, A., Vanden, Berghe, W., Plaisance, S., Lee, J.C., Haegeman, G., Cohen, P., Fiers, W. (1996). The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J. 15:1914-1923.
5. Chae, H.J., Chae, S.W., Weon, K.H., Kang, I.S., Kim, H.R. (1999) Signal Transduction of Thapsigargin-induced Apoptosis in Osteoblast. Bone 24:453-458.
6. Finkel, M.S., Oddis, C.V., Jacob, T.D., Watkins, S.C., Halter, B.G., Simmons, R.L. (1992) Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 257:387-389.
7. Hernandez, M., Bayon, Y., Sanchez, Crespo, M., Nieto, M.L. (1999) Signaling mechanisms involved in the activation of arachidonic acid metabolism in human astrocytoma cells by tumor necrosis factor-alpha: phosphorylation of cytosolic phospholipase A2 and transactivation of cyclooxygenase-2. J Neurochem. 73:1641-1649.
8. Hibi, M., Lin, A., Smeal, T., Minden, A., Karin, M. (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev.7:2135-2148.
9. Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., Kishimoto, T. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature.324(6092):73-76.
10. Horri, Y., Muraguchi, A., Suematsu, S., Matsuda, T., Yoshizaki, K., Hirano, T., Kishomoto, T. (1988) Regulation of BSF-2/IL-6 production by human mononuclear cells: macrophage-dependent synthesis of BSF-2/IL-6 by T cells. Journal of Immunology. 141:1529-1535.
11. Ikeda, U., Ohkawa, F., Seino, Y., Yamamoto, K., Hidaka, Y., Kasahara, T., Kawai, T., Shimada, K. (1992) Serum interleukin 6 levels become elevated in acute myocardial infarction. J Mol Cell Cardiol.24:579-584.
12. Jirik, F.R., Podor, T.J., Hirano, T., Kishimoto, T., Loskutoff, D.J., Carson, D.A., Lotz, M. (1989) Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol. 142(1):144-147.
13. Kohase, M., May, L.T., Tamm, I., Vilcek, J., Sehgal, P.B. (1987) A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol.Jan;7(1):273-280.
14. Kozawa, O., Tokuda, H., Matsuno, H., Uematsu, T. (1999) Involvement of p38 mitogenactivated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts. J Cell Biochem. 74:479-485.
15. Kumar, S., McDonnell, P.C., Gum, R.J., Hand, A.T., Lee, J.C., Young, P.R. (1997) Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun.235:533-538.
16. Li, Z., Jiang, Y., Ulevitch, R.J., Han, J. (1996) The primary structure of p38γ: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun.228:334-340.
17. Loppnow, H., Libby, P. (1990) Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6. J Clin Invest.85:731-738.
18. Ludwig, S., Hoffmeyer, A., Goebeler, M., Kilian, K., Hafner, H., Neufeld, B., Han, J., Rapp, U.R. (1998) The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J Biol Chem.273:1917-1922.
19. Nijisten, M.W.N., De, Groot, E.R., Ten, Duis, H.J., Hack, C.E., Aarden, L.A.(1987) Serum levels of interleukin-6 and acute phase response. Lancet.2:921.
20. Shapiro, L., Dinarello, C.A. (1995) Osmotic regulation of cytokine synthesis in vitro. Proc Natl Acad Sci USA.92:12230-12234.
21. Shapiro, L., Dinarello, C.A. (1997) Hyperosmotic stress as a stimulant for proinflammatory cytokine production. Exp Cell Res.231:354-362.
22. Van, Snick, J. (1990) Interleukin-6: an overview. Annu Rev Immunol.8:253-278.
23. Yamakawa, T., Eguchi, S., Matsumoto, T., Yamakawa, Y., Numaguchi, K., Reynolds, C.M., Motley, E.D., Inagami, T. (1999) Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-κB and p38 mitogen-activated protein kinase on tumor necrosis factor-α production. Endocrinology. 140:3562-3572.
24. Yamazaki, T., Komuro, I., Zou, Y., Kudoh, S., Shiojima, I., Hiroi, Y., Mizuno, T., Aikawa, R., Takano, H., Yazaki, Y. (1998) Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both α1- and β-adrenoreceptors. Circulation. 95:1260-1268.
25. Zu, Y.L., Qi, J., Gilchrist, A., Fernandez, G.A., Vazquez-Abad, D., Kreutzer, D.L., Huang, C.K., and Sha'afi, R.I. (1998) p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J Immunol. 160:1982-1989.