Age-related changes in pharmacokinetics and pharmacodynamics of lerisetron in the rat: A population pharmacokinetic model

Gerontology

Volumn 49, Issue 4, 2003, Pages 205-214

  Jauregizar, Nerea ^a   Quintana, Antonio ^a   Suarez, Elena ^a   Raczka, Ewa ^a   De La Fuente, Leire ^a   Calvo, Rosario ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

5 HT3 receptor antagonist; Fischer 344 rats; Lerisetron, pharmacokinetics; Von Bezold Jarish reflex

Indexed keywords

ALBUMIN; LERISETRON; OROSOMUCOID;

AGING; ARTICLE; BLOOD SAMPLING; COMPUTER PROGRAM; CONTROLLED STUDY; COVARIANCE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONCENTRATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SENSITIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; POPULATION MODEL; POPULATION RESEARCH; PRIORITY JOURNAL; RAT; REFLEX; SENESCENCE;

AGING; ANIMALS; BAYES THEOREM; BENZIMIDAZOLES; FEMALE; HALF-LIFE; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PIPERIDINES; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 0037604512     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070400     Document Type: Article

References (24)

1. 3 antagonists: Synthesis and pharmacological evaluations. J Med Chem 1997;40:586-593.
2. 3 receptors. Trends Neurosci 1986;9:424-428.
3. Veyrat-Follet C, Farinotti R, Palmer JL: Physiology of chemotherapy-induced emesis and antiemetic therapy. Drugs 1997;53:206-234.
4. 3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. Drugs 1998;55:173-189.
5. Fozard JR, Host M: Selective inhibition of the Bezold-Jarisch effect of 5-HT in the rat by antagonists at neuronal 5-HT receptors. Br J Pharmacol 1982;77:550 (abstr).
6. 3 receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivates against 5-HT-induced bradycardia in anesthetized rats. Jpn J Pharmacol 1994;65:241-248.
7. Raczka E, Valle M, Zamacona MK, Quintana A, Garrido MJ, Jiménez RM, Suarez E, Troconiz IF, Calvo R: Pharmacokinetic/pharmacodynamic relationship of lerisetron in control and tumor-bearing rats: A preclinical study. 2nd Annu IBC Int Conf on Pharmacokinetic/Pharmacodynamic Analysis, Washington, 1995, pp 4.4.1-4.4.5.
8. Lukas JC, Calvo R, Jauregizar N, Suarez E, Zamacona M, Vale M, Raczka E: Lerisetron PK-PD in vivo. Experimental results and comparison with a pk (unbound concentration) pharmacodynamic theory. Br J Pharmacol 1998;124:5 (abstr).
9. 3 antagonist, in patients with cancer. Cancer Chemother Pharmacol 1998;42:418-422.
10. 1-acid glycoprotein. J Pharmacol Exp Ther 1996;276:918-922.
11. 1-acid glycoprotein in serum using quinaldine red. Pharm Res 1994;11:566-570.
12. Doumas BT, Watson W, Biggs HG: Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 1971;31:87-96.
13. Vozeh S, Maitre PO, Stanski DR: Evaluation of population (NONMEM) pharmacokinetic parameter estimates. J Pharmacokinet Biopharm 1990;18:161-173.
14. 1-acid glycoprotein levels. Pharm Res 2001;18:838-845.
15. 3 antagonist, in rats. J Pharm Sci 2002;91:41-52.
16. Satterwhite JH, Boudinot FD: Age- and dose-dependent naproxen disposition in Fischer 344 rats. J Gerontol 1991;46:222-227.
17. Sugihara N, Furuno K, Kita N, Murakami T, Yata N: The influence of increased plasma protein binding on the disposition of quinidine in turpentine-treated rats. Biol Pharm Bull 1993;16:63-67.
18. 1-acid glycoprotein on the pharmacokinetics of tamsulosin in rats treated with turpentine oil. J Pharm Sci 2000;89:490-498.
19. 1-acid glycoprotein and binding of basic drugs. Methods Find Exp Clin Pharmacol 1983;5:635-648.
20. 1-acid glycoprotein concentration in normal volunteers. J Pharm Sci 1985;74:777-779.
21. 1-acid glycoprotein concentration on erythromycin pharmacokinetics in pigs. Am J Vet Res 1995;56:362-365.
22. Boudinot SG, Funderburg ED, Boudinot FD: Effects of age on the pharmacokinetics of piroxicam in rats. J Pharm Sci 1993;82:254-257.
23. McMahon TF, Diliberto JJ, Birnbaum LS: Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats. Drug Metab Dispos 1990;18:494-503.
24. Hämmerlein A, Derendorf H, Lowenthal DT: Pharmacokinetic and pharmacodynamic changes in the elderly: Clinical implications. Clin Pharmacokinet 1998;35:49-64.