Altered disposition and effect of lerisetron in rats with elevated alpha1-acid glycoprotein levels

Pharmaceutical Research

Volumn 18, Issue 6, 2001, Pages 838-845

  Jauregizar, Nerea ^a   Calvo, Rosario ^a,b   Suarez, Elena ^a   Quintana, Antonio ^a   Raczka, Ewa ^a   Lukas, John C ^c  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF WASHINGTON   (United States)

^c University of Washington   (United States)

Author keywords

1 acid glycoprotein; Bezold Jarisch reflex; Effect alterations; Lerisetron; Serotonin; Unbound pharmacokinetics

Indexed keywords

LERISETRON; OROSOMUCOID; SEROTONIN; TURPENTINE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG PROTEIN BINDING; FEMALE; HERXHEIMER REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SCINTILLATION COUNTING; ULTRAFILTRATION;

ANIMALS; BENZIMIDAZOLES; BRADYCARDIA; FEMALE; OROSOMUCOID; PIPERIDINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN ANTAGONISTS;

EID: 0034866532     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011096714860     Document Type: Article

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