Somatic gene transfer and cardiac arrhythmias: Problems and prospects

Journal of Cardiovascular Electrophysiology

Volumn 14, Issue 5, 2003, Pages 547-550

  Tomaselli, Gordon F ^a   Donahue, J Kevin ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; BETA GALACTOSIDASE; CELL PROTEIN; DNA; GLYCERYL TRINITRATE; GUANINE NUCLEOTIDE BINDING PROTEIN; LIPOSOME; POTASSIUM CHANNEL; RETROVIRUS VECTOR; RIBOZYME; RNA; VASCULOTROPIN; VIRUS VECTOR;

ADOPTIVE IMMUNOTHERAPY; DRUG TARGETING; GENE GUN; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART MUSCLE POTENTIAL; HEART RHYTHM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRINAE; LONG QT SYNDROME; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RNA VIRUS; SOMATIC CELL GENETICS; STEM CELL; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE;

ARRHYTHMIA; CARDIOMYOPATHIES; CORONARY ARTERIOSCLEROSIS; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; POINT-OF-CARE SYSTEMS; PROBLEM-BASED LEARNING;

EID: 0037566665     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8167.2003.t01-1-02567.x     Document Type: Review

References (20)

1. Isner J: Myocardial gene therapy. Nature 2002;415:234-239.
2. Hughes S: Cardiac stem cells. J Pathol 2002;197:468-478.
3. Mann M, Gibbons GH, Kernoff RS, et al: Genetic engineering of vein grafts resistant to atherosclerosis. Proc Natl Acad Sci USA 1995;92:4502-4506.
4. Durlach J: A possible advance in arterial gene therapy for aortic complications in the Marfan syndrome by local transfer of an antisense Mg-dependent hammerhead ribozyme. Magnes Res 2001;14:65-67.
5. Robbins P, Tahara H, Ghivizzani SC: Viral vectors for gene therapy. Trends Biotechnol 1998;16:35-40.
6. Flotte T, Afione SA, Conrad C, et al: Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci USA 1993;94:1650.
7. Dong J, Fan PD, Frizzell RA: Quantative analysis of the packaging capacity of recombinant adeno-associated virus. Human Gene Ther 1996;7:2101-2112.
8. Koh G, Klug MG, Soonpaa MH, Field LJ: Differentiation and long-term survival of C2C12 myoblast grafts in heart. J Clin Invest 1993;92:1548-1554.
9. Reinecke H, MacDonald GH, Hauschka SD, Murry CE: Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J Cell Biol 2000;149:731-740.
10. Menasche P, Hagege AA, Scorsin M, et al: Myoblast transplantation for heart failure. Lancet 2001;357:279-280.
11. Donahue J, Heldman AH, Fraser H, et al: Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med 2000;6:1395-1398.
12. Giordano FJ, Ping PP, Mckirnan MD, et al: Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med 1996;2:534-539.
13. Tomaselli G, Marban E: Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 1999;42:270-283.
14. Nuss HB, Johns DC, Kaab S, Kass DA, Lawrence JH, Marban E: Reversal of potassium channel deficiency in cells from failing hearts by adenoviral gene transfer: A prototype for gene therapy for disorders of cardiac excitability and contractility. Gene Ther 1996;3:900-912.
15. Nuss B, Marban E, Johns D: Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. J Clin Invest 1999;103:889-896.
16. Nagata K, Marban E, Lawrence JH, Donahue JK: Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. J Mol Cell Cardiol 2001;33:575-580.
17. Miake J, Marban E, Nuss HB: Biological pacemaker created by gene transfer. Nature 2002;419:132-133.
18. Chen HH, Mack LM, Kelly R, Ontell M, Kochanek S, Clemens PR: Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc Natl Acad Sci USA 1997;94:1645-1650.
19. Donahue J, Kikkawa K, Johns DC, Marban E, Lawrence JH: Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci USA 1997;94:4664-4668.
20. Fussenegger M: The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies. Biotechnol Prog 2001;17:1-51.