Cloned cytosine deaminase gene expression of bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors

Bioscience, Biotechnology and Biochemistry

Volumn 66, Issue 11, 2002, Pages 2362-2366

  Nakamura, Toshiyuki ^a   Sasaki, Takayuki ^a   Fujimori, Minoru ^a   Yazawa, Kazuyuki ^a   Kano, Yasunobu ^b   Amano, Jun ^a   Taniguchi, Shun’ichiro ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Bifidobacterium longum; Cytosine deaminase; Enzyme pro drug therapy; Pbles100 S eCD

Indexed keywords

BACTERIA (MICROORGANISMS); BIFIDOBACTERIUM; BIFIDOBACTERIUM LONGUM; PROKARYOTA; UNIDENTIFIED SHUTTLE VECTOR;

ANTINEOPLASTIC ANTIMETABOLITE; CYTOSINE DEAMINASE; DEAMINASE; FLUCYTOSINE; FLUOROURACIL; PRODRUG;

ANOXIA; ARTICLE; BACTERIUM TRANSFORMATION; BIFIDOBACTERIUM; ENZYMOLOGY; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; NEOPLASM; PATHOPHYSIOLOGY; WESTERN BLOTTING;

ANOXIA; ANTIMETABOLITES, ANTINEOPLASTIC; BIFIDOBACTERIUM; BLOTTING, WESTERN; CLONING, MOLECULAR; CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; NEOPLASMS; NUCLEOSIDE DEAMINASES; PRODRUGS; TRANSFECTION; TRANSFORMATION, BACTERIAL;

EID: 0037544973     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.66.2362     Document Type: Article

References (19)

1. Brown, J. M., The hypoxic cell: a target for selective cancer therapy. Cancer Res., 59, 5863-5870 (1999).
2. Vaupel, P. W., In “Oxygenation of solid tumors in drug resistance in oncology”, ed. Teicher, B. A., Marcel Dekker, New York, pp. 53-85 (1993).
3. Kimura, N. T., Taniguchi, S., Aoki, K., and Baba, T., Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res., 40, 2061-2068 (1980).
4. Fox, M. E., Lemmon, M. J., Mauchline, M. L., Davis, T. O., Giaccia, A. J., Minton, N. P., and Brown, J. M., Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Gene Ther., 3, 173-178 (1996).
5. Theys, J., Landuyt, W., Nuyts, S., Van Mellaert, L., van Oosterom, A., Lambin, P., and Anne, J., Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther., 8, 294-297 (2001).
6. Theys, J., Landuyt, W., Nuyts, S., Van Mellaert, L., Bosmans, E., Rijnders, A., Van Den Bogaert, W., van Oosterom, A., Anne, J., and Lambin, P., Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas. FEMS Immunol. Med. Microbiol., 30, 37-41 (2001).
7. Matsumura, H., Takeuchi, A., and Kano, Y., Construction of Escherichia coli-Bifidobacterium longum shuttle vector transforming B. longum 105-A and 108-A. Biosci. Biotechnol. Biochem., 61, 1211-1212 (1997).
8. Yazawa, K., Fujimori, M., Amano, J., and Kano, Y., Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors. Cancer Gene Ther., 7, 269-274 (2000).
9. Yazawa, K., Fujimori, M., Nakamura, T., Sasaki, T., Amano, J., Kano, Y., and Taniguchi, S., Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat tumors. Breast Cancer Res., 66, 165-170 (2001).
10. Goshima, N., Kano, Y., and Imamoto, F., Characterization of HU-like protein from Bifidobacterium longum. Biochimie, 72, 207-212 (1990).
11. Briggs, N., The classification of lactobacilli by means of physiological tests. J. Gen. Microbiol., 9, 234-248 (1953).
12. Natori, Y., Kano, Y., and Imamoto, F., Characterization and promoter selectivity of Lactobacillus acidophilus RNA polymerase. Biochimie, 70, 1765-1774 (1988).
13. Takeuchi, A., Matsumura, H., and Kano, Y., Cloning and expression in Escherichia coli of a gene, hup, encoding the histone-like protein HU of Bifidobacterium longum. Biosci. Biotechnol. Biochem., 66, 598-603 (2002).
14. Pawelek, J. M., Low, K. B., and Bermudes, D., Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res., 57, 4537-4544 (1997).
15. Theys, J., Landuyt, W., Nuyts, S., Van Mellaert, L., van Oosterom, A., Lambin, P., and Anne, J., Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther., 8, 294-297 (2001).
16. Hone, D. M., Tacket, C. O., Harris, A. M., Kay, B., Losonsky, G., and Levine, M. M., Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine. J. Clin. Invest., 90, 412-420 (1992).
17. Tacket, C. O., Hone, D. M., Curtiss, R., III., Kelly, S. M., Losonsky, G., Guers, L., Harris, A. M., Edelman, R., and Levine, M. M., Comparison of the safety and immunogenicity of delta aroC delta aroD and delta cya delta crp Salmonella typhi strains in adult volunteers. Infect. Immun., 60, 536-541 (1992).
18. Reddy, B. S., and Rivenson, A., Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methyli-midazo[4,5-f] quinoline, a food mutagen. Cancer Res., 53, 3914-3918 (1993).
19. Saavedra, J. M., Bauman, N. A., Oung, I., Perman, J. A., and Yolken, R. H., Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. Lancet, 344, 1046-1049 (1994).