Autoimmune response to advanced glycosylation end-products of human LDL

Journal of Lipid Research

Volumn 44, Issue 3, 2003, Pages 487-493

  Virella, Gabriel ^a   Thorpe, Suzanne R ^b   Alderson, Nathan L ^b   Stephan, Elias M ^a   Atchley, Daniel ^a   Wagner, Francesco ^a   Lopes Virella, Maria F ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Advanced glycosylation end products LDL antibodies; Diabetes; Immunogenicity of advanced glycosylation end products LDL; Modified lipoproteins

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AUTOANTIBODY; LOW DENSITY LIPOPROTEIN; SERUM ALBUMIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANTIBODY DETECTION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CROSS REACTION; DIABETES MELLITUS; ENZYME IMMUNOASSAY; GLYCOSYLATION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; PRIORITY JOURNAL; AUTOIMMUNITY; BLOOD; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; ISOLATION AND PURIFICATION; METABOLISM; OXIDATION REDUCTION REACTION;

AUTOANTIBODIES; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IMMUNOENZYME TECHNIQUES; LIPOPROTEINS, LDL; OXIDATION-REDUCTION;

EID: 0037534903     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M200370-JLR200     Document Type: Article

References (51)

1. Fu, M. X., J. R. Requena, A. J. Jenkins, T. J. Lyons, J. W. Baynes, and S. R. Thorpe. 1996. The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions. J. Biol. Chem. 271: 9982-9986.
2. Onorato, J. M., S. R. Thorpe, and J. W. Baynes. 1998. Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. Ann. N. Y. Acad. Sci. 854: 277-290.
3. Requena, J. R., M. X. Fu, M. U. Ahmed, A. J. Jenkins, T. J. Lyons, J. W. Baynes, and S. R. Thorpe. 1997. Quantification of malondialdehyde and 4-hydroxynonenal adducts to lysine residues in native and oxidized humn low-density lipoproteins. Biochem. J. 322: 317-325.
4. Schmidt, A. M., O. Hori, J. X. Chen, J. F. Li, J. Crandall, J. Zhang, R. Cao, S. D. Yan, J. Brett, and D. Stern. 1995. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J. Clin. Invest. 96: 1395-1403.
5. Schmidt, A. M., S. D. Yan, S. F. Yan, and D. M. Stern. 2001. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J. Clin. Invest. 108: 949-955.
6. Vlassara, H., R. Bucala, and L. Striker. 1994. Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging. Lab. Invest. 70: 138-151.
7. Ikeda, K., R. Nagai, T. Sakamoto, H. Sano, T. Araki, N. Sakata, H. Nakayama, M. Yoshida, S. Ueda, and S. Horiuchi. 1998. Immunochemical approaches to AGE-structures: characterization of anti-AGE antibodies. J. Immunol. Methods. 215: 95-104.
8. Nakamura, Y., Y. Horii, T. Nishino, H. Shiiki, Y. Sakaguchi, T. Kagoshima, K. Dohi, Z. Makita, H. Vlassara, and R. Bucala. 1993. Immunochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes melitus. Am. J. Pathol. 143: 1649-1656.
9. Lucey, M. D., M. M. Newkirk, C. Neville, K. Lepage, and P. R. Fortin. 2000. Association between IgM response to IgG damaged by glyoxidation and disease activity in rheumatoid arthritis. J. Rheumatol. 27: 319-323.
10. Turk, Z., S. Ljubic, N. Turk, and B. Benko. 2001. Detection of autoantibodies against advanced glycation endproducts and AGE-immune complexes in serum of patients with diabetes mellitus. Clin. Chim. Acta. 303: 105-115.
11. Vay, D., M. Vidali, G. Allochis, C. Cusaro, R. Rolla, E. Mottaran, G. Bellomo, and E. Albano. 2000. Antibodies against advanced glycation end product Nepsilon-(carboxymethyl)lysine in healthy controls and diabetic patients. Diabetologia. 43: 1385-1388.
12. Lopes-Virella, M. F., and G. Virella. 1998. The immunology of atherosclerosis. In Diabetes Annual. S. M. Marshall, P. D. Home, and R. A. Rizza, R.A., editors. vol. 11. Elsevier, Amsterdam. 81-95.
13. Lopes-Virella, M. F., G. Virella, T. J. Orchard, S. Koskinen, R. W. Evans, D. J. Becker, and K. Y. Forrest. 1999. Antibodies to oxidized LDL and LDL-containing immune complexes as risk factors for coronary artery disease in diabetes mellitus. Clin. Immunol. 90: 165-172.
14. Yla-Herttuala, S., W. Palinski, M. E. Rosenfeld, S. Parthasarathy, T. E. Carew, S. Butler, J. L. Witztum, and D. Steinberg. 1989. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84: 1086-1095.
15. Yla-Herttuala, S., W. Palinski, S. Butler, S. Picard, D. Steinberg, and J. L. Witztum. 1994. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler. Thromb. 14: 32-40.
16. Griffith, R. L., G. T. Virella, H. C. Stevenson, and M. F. Lopes-Virella. 1988. Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. A possible mechanism of foam cell formation. J. Exp. Med. 168: 1041-1059.
17. Huang, Y., A. J. Fleming, S. Wu, G. Virella, and M. F. Lopes-Virella. 2000. Fc-gamma receptor cross-linking by immune complexes induces matrix metalloproteinase-1 in U937 cells via mitogen-activated protein kinase. Arterioscler. Thromb. Vase. Biol. 20: 2533-2538.
18. Virella, G., J. F. Munoz, G. M. Galbraith, C. Gissinger, C. Chassereau, and M. F. Lopes-Virella. 1995. Activation of human monocyte-derived macrophages by immune complexes containing low-density lipoprotein. Clin. Immunol. Immunopathol. 75: 179-189.
19. Mironova, M., G. Virella, and M. F. Lopes-Virella. 1996. Isolation and characterization of human antioxidized LDL autoantibodies. Arterioscler. Thromb. Vasc. Biol. 16: 222-229.
20. Mironova, M., G. Virella, I. Virella-Lowell, and M. F. Lopes-Virella. 1997. Anti-modified LDL antibodies and LDL-containing immune complexes in IDDM patients and healthy controls. Clin. Immunol. Inmunopathol. 85: 73-82.
21. Virella, G. 2001. Biosynthesis, metabolism, and biological properties of immunoglobulins. In Medical Immunology. 5th edition. G. Virella, editor. Marcel Dekker, New York. 93-104.
22. Virella, G., and G. Tsokos. 2001. Immune complex diseases. In Medical Immunology. 5th edition. G. Virella, editor. Marcel Dekker, New York. 453-471.
23. Virella, G., S. Koskinen, G. Krings, J. M. Onorato, S. R. Thorpe, and M. Lopes-Virella. 2000. Immunochemical characterization of purified human oxidized low-density lipoprotein antibodies. Clin. Immunol. 95: 135-144.
24. Schmidt, A. M., S. D. Yan, J. Brett, R. Mora, R. Nowygrod, and D. Stern. 1993. Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products. J. Clin. Invest. 91: 2155-2168.
25. Lowry, O. H., N. J. Rosebrough, A. I. Farr, and A. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Bio. Chem. 193: 265-275.
26. Virella, G., I. Virella, R. B. Leman, M. B. Pryor, and M. F. Lopes-Virella. 1993. Anti-oxidized low-density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. Int. J. Clin. Lab. Res. 23: 95-101.
27. Friguet, B., A. F. Chaffotte, L. Djavadi-Ohaniance, and M. E. Goldberg. 1985. Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay. J. Immunol. Methods. 77: 305-319.
28. Mironova, M. A., R. L. Klein, G. T. Virella, and M. F. Lopes-Virella. 2000. Anti-modified LDL antibodies, LDL-containing immune complexes, and susceptibility of LDL to in vitro oxidation in patients with type 2 diabetes. Diabetes. 49: 1033-1041.
29. Atchley, D. H., M. F. Lopes-Virella, D. Zheng, and G. Virella. 2002. Oxidized LDL-Anti-Oxidized LDL immune complexes and diabetic nephropathy. Diabetologia. 45: 1562-1571.
30. Kannel, W. B., and D. L. McGee. 1979. Diabetes and cardiovascular disease. The Framingham study. JAMA. 241: 2035-2038.
31. Ross, R. 1999. Atherosclerosis-An inflammatory disease. N. Engl. J. Med. 340: 115-126.
32. Emeson, E. E., and A. L. J. Robertson. 1988. T lymphocytes in aortic and coronary intimas: Their potential role in atherogenesis. Am. J. Pathol. 130: 369-376.
33. Hansson, G. K., J. Holm, and L. Jonasson. 1989. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am. J. Pathol. 135: 169-175.
34. Hansson, G. K. 1999. Inflammation and immune response in atherosclerosis. Curr. Atheroscler. Rep. 1: 150-155.
35. Hansson, G. K., G. Bondjers, A. Bylock, and L. Hjalmarsson. 1980. Ultrastructural studies on the localization of IgG in the aortic endothelium and subendothelial intima of atherosclerotic and nonatherosclerotic rabbits. Exp. Mol. Pathol. 33: 302-315.
36. Parums, D., and M. J. Mitchinson. 1981. Demonstration of immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis. 38: 211-216.
37. Gisinger, C., G. T. Virella, and M. F. Lopes-Virella. 1991. Erythrocyte-bound low-density lipoprotein immune complexes lead to cholesteryl ester accumulation in human monocyte-derived macrophages. Clin. Immunol. Immunopathol. 59: 37-52.
38. Klimov, A. N., A. D. Denisenko, A. G. Vinogradov, V. A. Nagornev, Y. I. Pivovarova, O. D. Sitnikova, and V. M. Pleskov. 1988. Accumulation of cholesteryl esters in macrophages incubated with human lipoprotein-antibody autoimmune complex. Atherosclerosis. 74: 41-46.
39. Orekhov, A. N., and V. V. Tertov. 1990. Antibody-like immunoglobulins G against low density lipoprotein that stimulate lipid accumulation in cultured cells. In Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia. C. L. Malmandier, editor. Plenum Press, New York. 399-404.
40. Orchard, T. J., G. Virella, K. Y. Forrest, R. W. Evans, D. J. Becker, and M. F. Lopes-Virella. 1999. Antibodies to oxidized LDL predict coronary artery disease in type 1 diabetes: a nested case-control study from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes. 48: 1454-1458.
41. Lopes-Virella, M. F., R. L. Klein, and G. Virella. 1996. Modification of lipoproteins in diabetes. Diabetes Metab. Rev. 12: 69-90.
42. Mullarkey, C. J., D. Edelstein, and M. Brownlee. 1990. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem. Biophys. Res. Commun. 173: 932-939.
43. Baynes, J. W. 1991. Role of oxidative stress in development of complications in diabetes. Diabetes. 40: 405-412.
44. Baynes, J. W., and S. R. Thorpe. 2000. Glycoxidation and lipoxidation in atherogenesis. Free Radic. Biol. Med. 28: 1708-1716.
45. Palinski, W., S. Yla-Herttuala, M. E. Rosenfeld, S. W. Butler, S. A. Socher, S. Parthasarathy, L. K. Curtiss, and J. L. Witztum. 1990. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis. 10: 325-335.
46. Palinski, W., T. Koschinsky, S. W. Butler, E. Miller, H. Vlassara, A. Cerami, and J. L. Witztum. 1995. Immunological evidence for the presence of advanced glycosylation end products in atherosclerotic lesions of euglycemic rabbits. Arterioscler. Thromb. Vasc. Biol. 15: 571-582.
47. Steinbrecher, U. P., M. Fisher, J. L. Witztum, and L. K. Curtiss. 1984. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine. J. Lipid Res. 25: 1109-1116.
48. Shibayama, R., N. Araki, R. Nagai, and S. Horiuchi. 1999. Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction. Diabetes. 48: 1842-1849.
49. Kilpatrick, J. M., A. Pitt, S. K. Ainsworth, and G. Virella. 1985. Validation of the PEG-IgG screening test for soluble immune complexes by longitudinal studies in experimental acute serum sickness. J. Clin. Lab. Immunol. 17: 79-84.
50. Virella, G., J. M. Kilpatrick, F. Chenais, and H. H. Fudenberg. 1981. Isolation of soluble immune complexes from human serum: Combined use of polyethylene glycol precipitation, gel filtration, and affinity chromatography on protein A - Sepharose. Methods Enzymol. 74: 644-663.
51. Virella, G. 2001. Phagocytic cells. In Medical Immunology. 5th edition. G. Virella, editor. Marcel Dekker, New York. 245-258.