Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy

Human Pathology

Volumn 34, Issue 6, 2003, Pages 541-548

  Bouzourene, Hanifa ^a   Bosman, Fred T ^b   Matter, Maurice ^b   Coucke, Philippe ^b  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

^b NONE

Author keywords

Cancer; Preoperative radiotherapy; Rectum

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PROGNOSIS; PROSPECTIVE STUDY; RECTUM CANCER; TREATMENT OUTCOME;

EID: 0037531725     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(03)00176-X     Document Type: Article

References (39)

1. Swedish Rectal Cancer Trial: Local recurrence rate in a randomized multicentre trial of preoperative radiotherapy compared with operation alone in resectable rectal carcinoma. Eur J Surg 162:397-402, 1996
2. Stockholm Colorectal Cancer Study Group: Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer 66:49-55, 1990
3. Pahlman L, Glimelius B: Pre- and postoperative radiotherapy in rectal and rectosigmoid carcinoma: Report from a randomized multicentre trial. Ann Surg 211:187-195, 1990
4. Medical Research Council Rectal Cancer Working Party: Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet 348:1605-1610, 1996
5. Coucke PA, Sartorelli B, Cuttat JF, et al: The rationale to switch from postoperative hyperfractionated accelerated radiotherapy to preoperative hyperfractionated accelerated radiotherapy in rectal cancer. Int J Rad Oncol Biol Phys 32:181-188, 1995
6. Coucke PA: On behalf of the participants to trial 93-01: Curative resection rate after hyperfractionated accelerated radiotherapy (HART) immediately followed by surgery in locally advanced rectal cancer [abstract]. Radiother Oncol 43:S45, 1997
7. Sobin LH, Wittekind C (eds): IUCC TNM Classification of Malignant Tumors (ed 5). New York, Wiley, 1997
8. World Health Organization: International Histological Classification of Tumours, in Jass RJ, Sobin LH (eds): Histological Typing of Intestinal Tumours (ed 2). Berlin, Springer-Verlag, 1989
9. Mandard AM, Dalibard F, Mandard JC, et al: Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 73: 2680-2686, 1994
10. Bouzourene H, Bosman FT, Seelentag W, et al: Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 94:1121-1130, 2002
11. Quirke P, Durdey P, Dixon MF, et al: Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 1:996-998, 1986
12. MacFarlane JK, Ryall RD, Heald RJ: Mesorectal excision for rectal cancer. Lancet 341:457-460, 1993
13. Dahlberg M, Glimelius B, Pahlman L: Improved survival and reduction in local failure rates after preoperative radiotherapy: Evidence for the generalizability of the results of the Swedish Rectal Cancer Trial. Ann Surg 229:493-497, 1999
14. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638-646, 2001
15. Gerard A, Buyse M, Nordlinger B, et al: Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 208:606-614, 1988
16. Camma C, Giunta M, Fiorica F, et al: Preoperative radiotherapy for resectable rectal cancer: A meta-analysis. JAMA 284:1008-1015, 2000
17. Goldberg PA, Nicholls RJ, Porter NH, et al: Long-term results of a randomised trial of short-course low-dose adjuvant preoperative radiotherapy for rectal cancer: Reduction in local treatment failure. Eur J Cancer 30:1597-1599, 1994
18. Reed WP, Garb JL, Stark AJ, et al: 10-year results of preoperative radiotherapy in treatment of rectal carcinoma. Chirurg 67: 621-624, 1996
19. Stockholm Colorectal Cancer Study Group: Randomized study on preoperative radiotherapy in rectal carcinoma. Ann Surg Oncol 3:423-430, 1996
20. Swedish Rectal Cancer Trial: Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336: 980-987, 1997
21. Petersen S, Hellmich G, Baumann M, et al: Brief preoperative radiotherapy in surgical therapy of rectal carcinoma. Long-term results of a prospective randomized study. Chirurg 69:759-765, 1998
22. Glimelius B, Isacsson U, Jung B, et al: Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a close-response effect favoring preoperative treatment. Int J Radiat Oncol Biol Phys 15:281-287, 1997
23. Medical Research Council Rectal Cancer Working Party: Second report. The evaluation of low-dose pre-operative X-ray therapy in the management of operable rectal cancer: Results of a randomly controlled trial. Br J Surg 71:21-25, 1984
24. Willett CG, Badizadegan K, Ancukiewicz M, et al: Prognostic factors in stage T3N0 rectal cancer: Do all patients require postoperative pelvic irradiation and chemotherapy? Dis Colon Rectum 42:167-173, 1999
25. De Haas-Kock DF, Baeten CG, Jager JJ, et al: Prognostic significance of radial margins of clearance in rectal cancer. Br J Surg 83:781-785, 1996
26. Berger C, de Muret A, Garaud P, et al: Preoperative radiotherapy (RT) for rectal cancer. Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications. Int J Radiat Oncol Biol Phys 37:619-627, 1997
27. Gerard JP, Chapet O, Morignat E, et al: Preoperative radiotherapy of rectal cancer. The Lyons experience, 1985-1996. Prognostic study apropos of 312 patients. Ann Chir 53:1003-1010, 1999
28. Kaminsky-Forett MC, Conroy T, Luporsi E, et al: Prognostic implication of downstaging following preoperative radiation for operable T3-T4 rectal cancer. Int J Radiat Oncol Biol Phys 42:935-941, 1998
29. Graf W, Dahlberg M, Osman MM, et al: Short-term preoperative radiotherapy results in down-staging of rectal cancer: A study of 1316 patients. Radiother Oncol 43:133-137, 1997
30. Read TE, McNevin MS, Gross EK, et al: Neoadjuvant therapy for adenocarcinoma of the rectum: Tumor response and acute toxicity. Dis Colon Rectum 44:513-522, 2001
31. Cedermark B, Johansson H, Hutqvist LE, et al: The Stockholm I trial of preoperative short-term radiotherapy in operable rectal carcinoma. A prospective randomized trial. The Stockholm Colorectal Cancer Study Group. Cancer 75:2269-2275, 1995
32. Marijnen CA, Nagtegaal ID, Klein-Kranenbarg E, et al: No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J Clin Oncol 19:1976-1984, 2001
33. Symonds DA, Vickery AL Jr: Mucinous carcinoma of the colon and rectum. Cancer 37:1891-1900, 1976
34. Nagtegaal ID, Marijnen CAM, Kranenbarg EK, et al: Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer. J Pathol 197:20-27, 2002
35. Qizilbash AH: Pathologic studies in colorectal cancer. A guide to the surgical pathology examination of colorectal specimens and review of features of prognostic significance. Pathol Annu 17:1-46, 1982
36. Nagtegaal ID, Marijnen CAM, Kranenbarg EK, et al: Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma. Am J Surg Pathol 26:350-357, 2002
37. Rew DA, Wilson GD, Taylor I, et al: Proliferation characteristics of human colorectal carcinomas measured in vivo. Br J Surg 78:60-66, 1991
38. Terry NH, Meistrich ML, Roubein LD, et al: Cellular kinetics in rectal cancer. Br J Cancer 72:435-441, 1995
39. Voelter V, Stupp R, Matter M.: Preoperative hyperfractionated accelerated radiotherapy (HART) and concomitant CPT-11 in advanced rectal carcinoma. A phase I trial [abstract]. Ann Oncol 13(suppl 5):90, 2002