Short-term preoperative radiotherapy results in down-staging of rectal cancer: A study of 1316 patients

Radiotherapy and Oncology

Volumn 43, Issue 2, 1997, Pages 133-137

  Graf, Wilhelm ^a   Dahlberg, Michael ^a   Osman, M Mazloum ^a,b   Holmberg, Lars ^a   Påhlman, Lars ^a   Glimelius, Bengt ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Down staging; Lymph node metastases; Pathology; Radiotherapy; Rectal carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER SIZE; CANCER STAGING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; REGRESSION ANALYSIS;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS;

EID: 0030951055     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(96)01867-1     Document Type: Article

References (23)

1. Duncan, W., Smith, A.N., Freedman, L.S. et al. The evaluation of low dose preoperative X-ray therapy in the management of operable rectal cancer. Br. J. Surg. 71: 21-25, 1984.
2. Enker, W.E., Heiwell, M.L., Hertz, R.L. et al. En bloc pelvic lymphadenectomy and sphincter preservation in the surgical management of rectal cancer. Ann. Surg. 203: 426-433, 1986.
3. Fisher, B., Wolmark, N., Rockette, H. et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP Protocol R-01. J. Natl. Cancer Inst. 80: 21-29, 1988.
4. Fowler, J.F. The linear quadratic formula and progress in fractionated radiotherapy. Br. J. Radiol. 62: 679-694, 1989.
5. Frykholm, G., Glimelius, B. and Påhlman, L. Preoperative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects. Dis. Colon Rectum 36: 564-572, 1993.
6. Gerard, A., Buyse, M., Nordlinger, B. et al. Preoperative radiotherapy as adjuvant treatment in rectal cancer. Ann. Surg. 208: 606-614, 1988.
7. Glimelius, B., Isacsson, U., Jung, B. and Påhlman, L. Radiotherapy in addition to radical surgery in rectal cancer. Acta Oncol. 34: 565-570, 1995.
8. Goldberg, P.A., Nicholls, R.J., Porter, N.H., Love, S. and Grimsey, J.E. Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: reduction in local treatment failure. Eur. J. Cancer 30A: 1602-1606, 1994.
9. Heald, R.J. and Ryall, R.D.H. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet ii: 1479-1482, 1986.
10. Hojo, K. Anastomotic recurrence after sphincter saving resection for rectal cancer. Length of distal clearance of the bowel. Dis. Colon Rectum 29: 11-14, 1986.
11. Holmberg, L., Lindgren, A., Nordén, T., Adami, H.-O. and Bergström, R. Age as a determinant of axillary node involvement in invasive breast cancer. Acta Oncol. 31: 533-538, 1992.
12. Horn, A., Halvorsen, J.F. and Dahl, O. Preoperative radiotherapy in operable rectal cancer. Dis. Colon Rectum 33: 823-828, 1990.
13. Krook, J.E., Moertel, C.G., Gundersson, L.L. et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N. Engl. J. Med. 324: 709-715, 1991.
14. Labianca, R., Marsoni, S., Pancera, G. et al. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 345: 939-944, 1995.
15. Marsh, P.J., James, R.D. and Schofield, P.F. Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma. Results of a prospective randomized trial. Dis. Colon Rectum 37: 1205-1214, 1994.
16. National Cancer Institute. Clinical announcement. Adjuvant therapy of rectal cancer. March 14, 1991.
17. Påhlman, L. and Glimelius, B. Pre-or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Ann. Surg. 211: 187-195, 1990.
18. Riethmuller, G., Schneider-Gädicke, E., Schlimok, G. et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 343: 1177-1183, 1994.
19. Stockholm Rectal Cancer Study Group. Preoperative short term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer 66: 49-55, 1990.
20. Swedish Rectal Cancer Trial. Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Br. J. Surg. 80: 1333-1336, 1993.
21. Swedish Rectal Cancer Trial. Local recurrence rate in a randomized multicentre trial of preoperative radiotherapy compared with operation alone in resectable rectal carcinoma. Eur. J. Surg. 162: 397-402, 1996.
22. Swedish Rectal Cancer Trial. Increased 5-years survival after preoperative irradiation in rectal cancer. Int. J. Colored. Dis. 11: 128, 1996.
23. Treumiet-Donker, A.D., van Putten, W.L.J., Wereldsma, J.C.J. et al. Postoperative radiation therapy for rectal cancer. Cancer 67: 2042-2048, 1991.