Versatile synthesis of chiral 2-substituted-5-oxo-1,2,3,4-tetrahydro-5H-1,4-benzodiazepines as novel scaffolds for peptidomimetic building

Tetrahedron

Volumn 59, Issue 25, 2003, Pages 4491-4499

  Herrero, Susana ^a   García López, M Teresa ^a   Cenarruzabeitia, Edurne ^b   Del Río, Joaquín ^b   Herranz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

1,4 benzodiazepine derivatives; 5 oxo 1,2,3,4 tetrahydro 5H 1,4 benzodiazepines; Amino acid derived amino nitriles; Lactamization; Peptidomimetics; Reduction; Strecker synthesis

Indexed keywords

1,6 DIOXO 1,2,3,3A,4,5 HEXAHYDROIMIDAZO[3,4 A][1,4] BENZODIAZEPINE; 2 [1 (1 METHOXY 1 TRIFLUOROMETHYLPHENYLACETYL)AMINO 2 PHENYLETHYL] 5 OXO 1,2,3,4 TETRAHYDRO 5H 1,4 BENZODIAZEPINE; 4 (1 METHOXY 1 TRIFLUOROMETHYLPHENYLACETYL) 2 [1 (1 METHOXY 1 TRIFLUOROMETHYLPHENYLACETYL) AMINO 2 PHENYLETHYL] 5 OXO 1,2,3,4 TETRAHYDRO 5H 1,4 BENZODIAZEPINE; 5 OXO 1,2,3,4 TETRAHYDRO 5H 1,4 BENZODIAZEPINE; ALDEHYDE DERIVATIVE; AMINONITRILE; ANTHRANILIC ACID METHYL ESTER; BENZODIAZEPINE DERIVATIVE; CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; NITRILE; PD 135; PHENYLALANINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; DRUG SYNTHESIS; LACTAMIZATION; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRECKER REACTION;

EID: 0037498304     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(03)00681-1     Document Type: Article

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