Branched peptides and conformationally constrained analogues from cyanomethyleneamino pseudopeptides

Tetrahedron Letters

Volumn 37, Issue 12, 1996, Pages 2083-2084

  Suárez Gea, M Luisa ^a   García López, M Teresa ^a   González Muñiz, Rosario ^a   Herrero, Susana ^a   Herranz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PSEUDOPEPTIDE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE;

EID: 0037922572     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00198-0     Document Type: Article

References (12)

1. Herranz, R.; Suárez-Gea, M.L.; Vinuesa, S.; García-López, M.T.; Martínez, A. Tetrahedron Lett. 1991, 32, 7579-7582.
2. Herranz, R.; Suárez-Gea, M.L.; Vinuesa, S.; García-López, M.T. J. Org. Chem. 1993, 58, 5186-5191. Herranz, R.; Suárez-Gea, M.L.; García-López, M.T.; González-Muñiz, R.; Johansen, N.L.; Madsen, K.; Thøgersen, H.; Suzdak, P. Tetrahedron Lett. 1993, 34, 8357-8360.
3. Herranz, R.; Suárez-Gea, M.L.; Vinuesa, S.; García-López, M.T. J. Org. Chem. 1993, 58, 5186-5191. Herranz, R.; Suárez-Gea, M.L.; García-López, M.T.; González-Muñiz, R.; Johansen, N.L.; Madsen, K.; Thøgersen, H.; Suzdak, P. Tetrahedron Lett. 1993, 34, 8357-8360.
4. Suárez-Gea, M.L.; Vinuesa, S.; García-López, M.T.; Pérez, C.; Herranz, R. Bioorg. Med. Chem. Lett. 1994, 4, 1491-1496.
5. González-Muñiz, R.; García-López, M.T.; Gómez-Monterrey, I.; Herranz, R.; Jimeno, M.L.; Suárez-Gea, M.L.; Johansen, N.L.; Madsen, K.; Thøgersen, H.; Suzdak, P. J. Med. Chem. 1995, 38, 1015-1021.
6. Suárez-Gea, M.L.; García-López, M.T.; Herranz, R. J. Org. Chem. 1994, 59, 3600-3603.
7. Picard, II.; Wiegandt, D.L.; Spatola, A.F. Peptides. Chemistry, Structure and Biology, Hodges, R.S. and Smith, J. eds. ESCOM: Leiden, 1994; pp 104-106, and references cited therein.
8. Tam, J.P. Proc. Natl. Acad. Sci. USA 1988, 85, 5409-5413.
9. Hagiwara, D.; Miyake, H.; Murano, K.; Morimoto, H.; Murai, M.; Fujii, T.; Nakanishi, I.; Matsuo, M. J. Med. Cem. 1993, 36, 2266-2278.
10. Fairlie, D.P.; Abbenante, G.; March, D.R. Curr. Med. Chem. 1995, 2, 654-686, and references cited therein.
11. All new compounds gave satisfactory analytical and spectrocopical data.
12. In the specification of chirality at the peptide bond surrogate the ligand preference in the products resulting from the hydrogenation of Ψ [CH(CN)NH] pseudopeptides change. Thus, (S)-epimers 1 are transformed into (R)-aminomethyleneamino derivatives.